1ic3 - Revision history

OCA at 10:59, 4 August 2021

OCA — Wed, 04 Aug 2021 10:59:16 GMT

←Older revision		Revision as of 10:59, 4 August 2021
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	<StructureSection load='1ic3' size='340' side='right'caption='[[1ic3]]' scene=''>		<StructureSection load='1ic3' size='340' side='right'caption='[[1ic3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ic3 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1ic3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic3 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ic3 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1ic3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:09, 30 October 2019

OCA — Wed, 30 Oct 2019 10:09:43 GMT

←Older revision		Revision as of 10:09, 30 October 2019
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	==THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE==		==THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE==
-	<StructureSection load='1ic3' size='340' side='right' caption='[[1ic3]]' scene=''>	+	<StructureSection load='1ic3' size='340' side='right'caption='[[1ic3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Bujnicki, J M]]		[[Category: Bujnicki, J M]]
	[[Category: Feder, M]]		[[Category: Feder, M]]
	[[Category: Radlinska, M]]		[[Category: Radlinska, M]]
	[[Category: Rychlewski, L]]		[[Category: Rychlewski, L]]

OCA at 09:10, 10 January 2018

OCA — Wed, 10 Jan 2018 09:10:44 GMT

←Older revision		Revision as of 09:10, 10 January 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic3 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ic3 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic3 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ic3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:02, 11 February 2016

OCA — Thu, 11 Feb 2016 09:02:06 GMT

←Older revision		Revision as of 09:02, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE==		==THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE==
	<StructureSection load='1ic3' size='340' side='right' caption='[[1ic3]]' scene=''>		<StructureSection load='1ic3' size='340' side='right' caption='[[1ic3]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Bujnicki, J M]]		[[Category: Bujnicki, J M]]
	[[Category: Feder, M]]		[[Category: Feder, M]]
	[[Category: Radlinska, M]]		[[Category: Radlinska, M]]
	[[Category: Rychlewski, L]]		[[Category: Rychlewski, L]]

OCA at 17:06, 10 September 2015

OCA — Thu, 10 Sep 2015 17:06:36 GMT

←Older revision		Revision as of 17:06, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ic3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:50, 2 January 2015

OCA — Fri, 02 Jan 2015 09:50:17 GMT

←Older revision		Revision as of 09:50, 2 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic3 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ic3 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic3 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ic3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:23, 28 September 2014

OCA — Sun, 28 Sep 2014 09:23:26 GMT

←Older revision		Revision as of 09:23, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE==
		+	<StructureSection load='1ic3' size='340' side='right' caption='[[1ic3]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IC3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic3 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ic3 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: The 5'-terminal cap structure plays an important role in many aspects of mRNA metabolism. Capping enzymes encoded by viruses and pathogenic fungi are attractive targets for specific inhibitors. There is a large body of experimental data on viral and cellular methyltransferases (MTases) that carry out guanine-N7 (cap 0) methylation, including results of extensive mutagenesis. However, a crystal structure is not available and cap 0 MTases are too diverged from other MTases of known structure to allow straightforward homology-based interpretation of these data. RESULTS: We report a 3D model of cap 0 MTase, developed using sequence-to-structure threading and comparative modeling based on coordinates of the glycine N-methyltransferase. Analysis of the predicted structural features in the phylogenetic context of the cap 0 MTase family allows us to rationalize most of the experimental data available and to propose potential binding sites. We identified a case of correlated mutations in the cofactor-binding site of viral MTases that may be important for the rational drug design. Furthermore, database searches and phylogenetic analysis revealed a novel subfamily of hypothetical MTases from plants, distinct from "orthodox" cap 0 MTases. CONCLUSIONS: Computational methods were used to infer the evolutionary relationships and predict the structure of Eukaryotic cap MTase. Identification of novel cap MTase homologs suggests candidates for cloning and biochemical characterization, while the structural model will be useful in designing new experiments to better understand the molecular function of cap MTases.

-	~~[[Image~~:~~1ic3~~.~~png\|left\|200px]]~~	+	mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships.,Bujnicki JM, Feder M, Radlinska M, Rychlewski L BMC Bioinformatics. 2001;2:2. Epub 2001 Jun 22. PMID:11472630<ref>PMID:11472630</ref>

-	~~{{STRUCTURE_1ic3\| PDB=1ic3 \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~===THEORETICAL MODEL OF~~ S.~~CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_11472630}}~~	+	__TOC__
-		+	</StructureSection>
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011472630<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bujnicki, J M]]		[[Category: Bujnicki, J M]]
	[[Category: Feder, M]]		[[Category: Feder, M]]
	[[Category: Radlinska, M]]		[[Category: Radlinska, M]]
	[[Category: Rychlewski, L]]		[[Category: Rychlewski, L]]

OCA: Protected "1ic3" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:40:57 GMT

Protected "1ic3" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:40, 21 October 2012

OCA at 09:40, 21 October 2012

OCA — Sun, 21 Oct 2012 09:40:54 GMT

←Older revision		Revision as of 09:40, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1ic3.png\|left\|200px]]		[[Image:1ic3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ic3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ic3\| PDB=1ic3 \| SCENE= }}		{{STRUCTURE_1ic3\| PDB=1ic3 \| SCENE= }}

	===THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE===		===THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11472630}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11472630 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11472630}}		{{ABSTRACT_PUBMED_11472630}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11472630~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011472630</ref><references group="xtra"/>
	[[Category: Bujnicki, J M]]		[[Category: Bujnicki, J M]]
	[[Category: Feder, M]]		[[Category: Feder, M]]
	[[Category: Radlinska, M]]		[[Category: Radlinska, M]]
	[[Category: Rychlewski, L]]		[[Category: Rychlewski, L]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:47:23 2010''

OCA at 05:47, 8 April 2010

OCA — Thu, 08 Apr 2010 05:47:24 GMT

←Older revision		Revision as of 05:47, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1ic3.png\|left\|200px]]

-	The ~~entry 1IC3 is a Theoretical Model titled 'THEORETICAL MODEL OF S~~.~~CEREVISIAE CAP 0~~ (~~MRNA:GUANINE-N7~~) ~~METHYLTRANSFERASE'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1ic3", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1ic3\| PDB=1ic3 \| SCENE= }}

-	~~[[Category~~:~~Theoretical Model]]~~	+	===THEORETICAL MODEL OF S.CEREVISIAE CAP 0 (MRNA:GUANINE-N7) METHYLTRANSFERASE===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:50:~~05 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_11472630}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11472630 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11472630}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC3 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:11472630</ref><references group="xtra"/>
		+	[[Category: Bujnicki, J M]]
		+	[[Category: Feder, M]]
		+	[[Category: Radlinska, M]]
		+	[[Category: Rychlewski, L]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:47:23 2010''