1ij4 - Revision history

OCA at 11:01, 4 August 2021

OCA — Wed, 04 Aug 2021 11:01:18 GMT

←Older revision		Revision as of 11:01, 4 August 2021
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	<StructureSection load='1ij4' size='340' side='right'caption='[[1ij4]]' scene=''>		<StructureSection load='1ij4' size='340' side='right'caption='[[1ij4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ij4 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1ij4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij4 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ij4 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1ij4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:53, 30 October 2019

OCA — Wed, 30 Oct 2019 09:53:40 GMT

←Older revision		Revision as of 09:53, 30 October 2019
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	==MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX==		==MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX==
-	<StructureSection load='1ij4' size='340' side='right' caption='[[1ij4]]' scene=''>	+	<StructureSection load='1ij4' size='340' side='right'caption='[[1ij4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Grynszpan, F]]		[[Category: Grynszpan, F]]
	[[Category: Legge, G B]]		[[Category: Legge, G B]]

OCA at 08:53, 10 January 2018

OCA — Wed, 10 Jan 2018 08:53:25 GMT

←Older revision		Revision as of 08:53, 10 January 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij4 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ij4 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij4 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ij4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:02, 11 February 2016

OCA — Thu, 11 Feb 2016 09:02:53 GMT

←Older revision		Revision as of 09:02, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX==		==MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX==
	<StructureSection load='1ij4' size='340' side='right' caption='[[1ij4]]' scene=''>		<StructureSection load='1ij4' size='340' side='right' caption='[[1ij4]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Grynszpan, F]]		[[Category: Grynszpan, F]]
	[[Category: Legge, G B]]		[[Category: Legge, G B]]

OCA at 06:04, 10 September 2015

OCA — Thu, 10 Sep 2015 06:04:25 GMT

←Older revision		Revision as of 06:04, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ij4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:30, 2 January 2015

OCA — Fri, 02 Jan 2015 09:30:23 GMT

←Older revision		Revision as of 09:30, 2 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij4 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ij4 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij4 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ij4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:49, 28 September 2014

OCA — Sun, 28 Sep 2014 10:49:05 GMT

←Older revision		Revision as of 10:49, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX==
		+	<StructureSection load='1ij4' size='340' side='right' caption='[[1ij4]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij4 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ij4 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The interaction of the alphaLbeta2 integrin with its cellular ligand the intercellular adhesion molecule-1 (ICAM-1) is critical for the tight binding interaction between most leukocytes and the vascular endothelium before transendothelial migration to the sites of inflammation. In this article we have modeled the alphaL subunit I-domain in its active form, which was computationally docked with the D1 domain of the ICAM-1 to probe potential protein-protein interactions. The experimentally observed key interaction between the carboxylate of Glu 34 in the ICAM-1 D1 domain and the metal ion-dependent adhesion site (MIDAS) in the open alphaL I-domain was consistently reproduced by our calculations. The calculations reveal the nature of the alphaLbeta2/ICAM-1 interaction and suggest an explanation for the increased ligand-binding affinity in the "open" versus the "closed" conformation of the alphaL I-domain. A mechanism for substrate selectivity among alphaL, alphaM, and alpha2 I-domains is suggested whereby the orientation of the loops within the I-domain is critical in mediating the interaction of the Glu 34 carboxylate of ICAM-1 D1 with the MIDAS.

-	~~[[Image~~:~~1ij4~~.~~png\|left\|200px]]~~	+	Model of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity.,Legge GB, Morris GM, Sanner MF, Takada Y, Olson AJ, Grynszpan F Proteins. 2002 Aug 1;48(2):151-60. PMID:12112684<ref>PMID:12112684</ref>

-	~~{{STRUCTURE_1ij4\| PDB=1ij4 \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~===MODEL OF THE ALB2 I-DOMAIN~~ / ~~ICAM-1 D1 COMPLEX===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_12112684}}~~	+	__TOC__
-		+	</StructureSection>
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012112684<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Grynszpan, F]]		[[Category: Grynszpan, F]]
	[[Category: Legge, G B]]		[[Category: Legge, G B]]

OCA: Protected "1ij4" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:26:20 GMT

Protected "1ij4" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:26, 21 October 2012

OCA at 09:26, 21 October 2012

OCA — Sun, 21 Oct 2012 09:26:17 GMT

←Older revision		Revision as of 09:26, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1ij4.png\|left\|200px]]		[[Image:1ij4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ij4", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1ij4\| PDB=1ij4 \| SCENE= }}		{{STRUCTURE_1ij4\| PDB=1ij4 \| SCENE= }}

	===MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX===		===MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12112684}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12112684 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12112684}}		{{ABSTRACT_PUBMED_12112684}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12112684~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012112684</ref><references group="xtra"/>
	[[Category: Grynszpan, F]]		[[Category: Grynszpan, F]]
	[[Category: Legge, G B]]		[[Category: Legge, G B]]
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	[[Category: Sanner, M F]]		[[Category: Sanner, M F]]
	[[Category: Takada, Y]]		[[Category: Takada, Y]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:19:06 2010''

OCA at 05:19, 8 April 2010

OCA — Thu, 08 Apr 2010 05:19:07 GMT

←Older revision		Revision as of 05:19, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1ij4.png\|left\|200px]]

-	The ~~entry 1IJ4~~ is ~~a Theoretical Model titled 'Model of~~ the ~~aLb2 I~~-~~domain / ICAM~~-~~1 D1 complex'.~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1ij4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1ij4\| PDB=1ij4 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===MODEL OF THE ALB2 I-DOMAIN / ICAM-1 D1 COMPLEX===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:50:~~08 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_12112684}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12112684 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12112684}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:12112684</ref><references group="xtra"/>
		+	[[Category: Grynszpan, F]]
		+	[[Category: Legge, G B]]
		+	[[Category: Morris, G M]]
		+	[[Category: Olson, A J]]
		+	[[Category: Sanner, M F]]
		+	[[Category: Takada, Y]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:19:06 2010''