1ill - Revision history

OCA at 11:02, 4 August 2021

OCA — Wed, 04 Aug 2021 11:02:03 GMT

←Older revision		Revision as of 11:02, 4 August 2021
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	<StructureSection load='1ill' size='340' side='right'caption='[[1ill]]' scene=''>		<StructureSection load='1ill' size='340' side='right'caption='[[1ill]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ILL FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ILL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ill FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1ill PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ill ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ill FirstGlance], [https://www.ebi.ac.uk/pdbsum/1ill PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ill ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:24, 30 October 2019

OCA — Wed, 30 Oct 2019 10:24:26 GMT

←Older revision		Revision as of 10:24, 30 October 2019
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	==THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING==		==THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING==
-	<StructureSection load='1ill' size='340' side='right' caption='[[1ill]]' scene=''>	+	<StructureSection load='1ill' size='340' side='right'caption='[[1ill]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ILL FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ILL FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Bamborough, P]]		[[Category: Bamborough, P]]
	[[Category: Hedgecock, C J]]		[[Category: Hedgecock, C J]]
	[[Category: Richards, W G]]		[[Category: Richards, W G]]

OCA at 09:25, 10 January 2018

OCA — Wed, 10 Jan 2018 09:25:15 GMT

←Older revision		Revision as of 09:25, 10 January 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ILL FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ILL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ill FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ill PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ill FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ill PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ill ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:03, 11 February 2016

OCA — Thu, 11 Feb 2016 09:03:40 GMT

←Older revision		Revision as of 09:03, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING==		==THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING==
	<StructureSection load='1ill' size='340' side='right' caption='[[1ill]]' scene=''>		<StructureSection load='1ill' size='340' side='right' caption='[[1ill]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Bamborough, P]]		[[Category: Bamborough, P]]
	[[Category: Hedgecock, C J]]		[[Category: Hedgecock, C J]]
	[[Category: Richards, W G]]		[[Category: Richards, W G]]

OCA at 15:53, 10 September 2015

OCA — Thu, 10 Sep 2015 15:53:02 GMT

←Older revision		Revision as of 15:53, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ill" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:35, 18 December 2014

OCA — Thu, 18 Dec 2014 12:35:07 GMT

←Older revision		Revision as of 12:35, 18 December 2014
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-	~~{{Theoretical_model}}~~	+	==THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING==
		+	<StructureSection load='1ill' size='340' side='right' caption='[[1ill]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ILL FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ill FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ill PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Interleukin-2 (IL2) and interleukin-4 (IL4) are members of the four-helix bundle family of cytokines, whose receptors show similarity to each other and to the growth hormone receptor fold. These proteins help to control, among other things, the rate of clonal expansion of lymphocytes, and thus play an important role in the regulation of the immune system. They are therefore of interest as transmembrane signalling proteins, as well as potential pharmaceutical targets. RESULTS: We have modelled structures of the extracellular components of the IL2 and IL4 receptors based on the structure of the complex of human growth hormone with its receptor, and incorporating the recently discovered shared gamma c chain. The models provide possible explanations for several experimental observations, including those from site-directed mutagenesis around the binding sites. Receptor residues that may be close to important side chains on IL2 and IL4 are identified and possible effects of their mutation are discussed. A comparison is made between the models and the growth hormone complex, and between the gamma c chain bound to IL2 and to IL4. CONCLUSIONS: The models offer structural explanations for observed behaviour such as the effects of mutation of the A- and D-helices of the cytokines. In addition, they may be of use in the identification of residues which may interact in the ligand-receptor interfaces, and which would therefore be worthy of further investigation.

-	~~{{STRUCTURE_1ill\| PDB=1ill \| SCENE= }}~~	+	The interleukin-2 and interleukin-4 receptors studied by molecular modelling.,Bamborough P, Hedgecock CJ, Richards WG Structure. 1994 Sep 15;2(9):839-51. PMID:7529123<ref>PMID:7529123</ref>
-	~~===THE INTERLEUKIN~~ 2 ~~AND INTERLEUKIN~~ 4 ~~RECEPTORS STUDIED BY MOLECULAR MODELLING===~~	+
-	~~{{ABSTRACT_PUBMED_7529123}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:007529123</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bamborough, P]]		[[Category: Bamborough, P]]
	[[Category: Hedgecock, C J]]		[[Category: Hedgecock, C J]]
	[[Category: Richards, W G]]		[[Category: Richards, W G]]

OCA at 22:21, 24 March 2013

OCA — Sun, 24 Mar 2013 22:21:12 GMT

←Older revision		Revision as of 22:21, 24 March 2013
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	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:1ill.png\|left\|200px]]

	{{STRUCTURE_1ill\| PDB=1ill \| SCENE= }}		{{STRUCTURE_1ill\| PDB=1ill \| SCENE= }}
-
	===THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING===		===THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING===
-
	{{ABSTRACT_PUBMED_7529123}}		{{ABSTRACT_PUBMED_7529123}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:007529123</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007529123</ref><references group="xtra"/><references/>
	[[Category: Bamborough, P]]		[[Category: Bamborough, P]]
	[[Category: Hedgecock, C J]]		[[Category: Hedgecock, C J]]
	[[Category: Richards, W G]]		[[Category: Richards, W G]]

OCA: Protected "1ill" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:54:16 GMT

Protected "1ill" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:54, 21 October 2012

OCA at 09:54, 21 October 2012

OCA — Sun, 21 Oct 2012 09:54:12 GMT

←Older revision		Revision as of 09:54, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1ill.png\|left\|200px]]		[[Image:1ill.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ill\| PDB=1ill \| SCENE= }}		{{STRUCTURE_1ill\| PDB=1ill \| SCENE= }}

	===THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING===		===THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7529123}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7529123 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_7529123}}		{{ABSTRACT_PUBMED_7529123}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7529123~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007529123</ref><references group="xtra"/>
	[[Category: Bamborough, P]]		[[Category: Bamborough, P]]
	[[Category: Hedgecock, C J]]		[[Category: Hedgecock, C J]]
	[[Category: Richards, W G]]		[[Category: Richards, W G]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:11:54 2010''

OCA at 06:11, 8 April 2010

OCA — Thu, 08 Apr 2010 06:11:55 GMT

←Older revision		Revision as of 06:11, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1ill.png\|left\|200px]]

-	The ~~entry 1ILL~~ is ~~a Theoretical Model titled 'THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1ill", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1ill\| PDB=1ill \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===THE INTERLEUKIN 2 AND INTERLEUKIN 4 RECEPTORS STUDIED BY MOLECULAR MODELLING===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30~~ 09:50:~~10 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_7529123}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 7529123 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_7529123}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:7529123</ref><references group="xtra"/>
		+	[[Category: Bamborough, P]]
		+	[[Category: Hedgecock, C J]]
		+	[[Category: Richards, W G]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:11:54 2010''