1imh - Revision history

OCA at 08:35, 16 August 2023

OCA — Wed, 16 Aug 2023 08:35:42 GMT

←Older revision		Revision as of 08:35, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1imh' size='340' side='right'caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>		<StructureSection load='1imh' size='340' side='right'caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1IMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IMH FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NFAT5 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.86Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [~~http~~://pdbe.org/1imh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1imh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1imh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [https://pdbe.org/1imh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [https://www.ebi.ac.uk/pdbsum/1imh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1imh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NFAT5_HUMAN NFAT5_HUMAN]] Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.	+	[https://www.uniprot.org/uniprot/NFAT5_HUMAN NFAT5_HUMAN] Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, L]]	+	[[Category: Chen L]]
-	[[Category: Lopez-Rodriguez, C]]	+	[[Category: Lopez-Rodriguez C]]
-	[[Category: Rao, A]]	+	[[Category: Rao A]]
-	[[Category: Stroud~~, J C]]~~	+	[[Category: Stroud JC]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Dna encirclement]]~~	+
-	~~[[Category: Double helix]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 10:40, 18 November 2020

OCA — Wed, 18 Nov 2020 10:40:12 GMT

←Older revision		Revision as of 10:40, 18 November 2020
Line 1:		Line 1:

	==TonEBP/DNA COMPLEX==		==TonEBP/DNA COMPLEX==
-	<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>	+	<StructureSection load='1imh' size='340' side='right'caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1IMH FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://pdbe.org/1imh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1imh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://pdbe.org/1imh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1imh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Lopez-Rodriguez, C]]		[[Category: Lopez-Rodriguez, C]]

OCA at 06:14, 4 April 2018

OCA — Wed, 04 Apr 2018 06:14:49 GMT

←Older revision		Revision as of 06:14, 4 April 2018
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	<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>		<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://pdbe.org/1imh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1imh ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://pdbe.org/1imh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1imh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/1imh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/1imh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Lopez-Rodriguez, C]]		[[Category: Lopez-Rodriguez, C]]

OCA at 10:50, 27 September 2017

OCA — Wed, 27 Sep 2017 10:50:14 GMT

←Older revision		Revision as of 10:50, 27 September 2017
Line 1:		Line 1:
		+
	==TonEBP/DNA COMPLEX==		==TonEBP/DNA COMPLEX==
	<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>		<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://pdbe.org/1imh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1imh ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://pdbe.org/1imh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1imh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Lopez-Rodriguez, C]]		[[Category: Lopez-Rodriguez, C]]

OCA at 12:30, 11 September 2015

OCA — Fri, 11 Sep 2015 12:30:25 GMT

←Older revision		Revision as of 12:30, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>		<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://pdbe.org/1imh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1imh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Lopez-Rodriguez, C]]		[[Category: Lopez-Rodriguez, C]]

OCA at 16:28, 25 December 2014

OCA — Thu, 25 Dec 2014 16:28:14 GMT

←Older revision		Revision as of 16:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NFAT5_HUMAN NFAT5_HUMAN]] Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, L.]]	+	[[Category: Chen, L]]
-	[[Category: Lopez-Rodriguez, C.]]	+	[[Category: Lopez-Rodriguez, C]]
-	[[Category: Rao, A.]]	+	[[Category: Rao, A]]
-	[[Category: Stroud, J C.]]	+	[[Category: Stroud, J C]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Dna encirclement]]		[[Category: Dna encirclement]]

OCA at 10:35, 28 September 2014

OCA — Sun, 28 Sep 2014 10:35:32 GMT

←Older revision		Revision as of 10:35, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1imh.~~png\|left~~\|200px]]	+	==TonEBP/DNA COMPLEX==
		+	<StructureSection load='1imh' size='340' side='right' caption='[[1imh]], [[Resolution\|resolution]] 2.86Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFAT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1imh RCSB], [http://www.ebi.ac.uk/pdbsum/1imh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/1imh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tonicity-responsive enhancer binding protein (TonEBP), also known as NFAT5, is a unique member of the NFAT family of transcription factors that regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of the NFAT family, TonEBP exists as a homodimer and binds asymmetric TonE DNA sites; furthermore, the affinity of TonEBP for DNA is much lower than that of other NFAT proteins. How TonEBP recognizes the TonE site and regulates the activation of hypertonicity response genes has not been clear. Here we show that TonEBP adopts a NF-kappaB-like structure upon binding to DNA, providing a direct structural link between the NFAT and NF-kappaB family of transcription factors. We also show that TonEBP completely encircles its DNA target and present biochemical evidence that the DNA encirclement may lead to increased kinetic stability of the TonEBP-DNA complex. Thus, the list of proteins that bind DNA by encirclement is now expanded to include sequence-specific transcription factors.

-	~~{{STRUCTURE_1imh\| PDB=1imh \| SCENE= }}~~	+	Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor.,Stroud JC, Lopez-Rodriguez C, Rao A, Chen L Nat Struct Biol. 2002 Feb;9(2):90-4. PMID:11780147<ref>PMID:11780147</ref>

-	~~===TonEBP~~/~~DNA COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11780147}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1imh]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011780147<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]

OCA: Protected "1imh" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 15:09:09 GMT

Protected "1imh" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:09, 28 November 2012

OCA at 15:09, 28 November 2012

OCA — Wed, 28 Nov 2012 15:09:07 GMT

←Older revision		Revision as of 15:09, 28 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1imh.png\|left\|200px]]		[[Image:1imh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1imh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1imh\| PDB=1imh \| SCENE= }}		{{STRUCTURE_1imh\| PDB=1imh \| SCENE= }}

	===TonEBP/DNA COMPLEX===		===TonEBP/DNA COMPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11780147}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11780147 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11780147}}		{{ABSTRACT_PUBMED_11780147}}

	==About this Structure==		==About this Structure==
-	~~1IMH~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA].	+	[[1imh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11780147~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011780147</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
Line 33:		Line 21:
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]
-		+	[[Category: Transcription-dna complex]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 21:45:42 2009''~~	+

OCA at 19:45, 17 February 2009

OCA — Tue, 17 Feb 2009 19:45:43 GMT

←Older revision		Revision as of 19:45, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1IMH is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA].	+	1IMH is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMH OCA].

	==Reference==		==Reference==
-	~~Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor., Stroud JC, Lopez-Rodriguez C, Rao A, Chen L, Nat Struct Biol. 2002 Feb;9(2):90-4.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11780147 11780147]~~	+	<ref group="xtra">PMID:11780147</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
	[[Category: Lopez-Rodriguez, C.]]		[[Category: Lopez-Rodriguez, C.]]
Line 35:		Line 34:
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 1 13~~:32:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:45:42 2009''