1in2 - Revision history

OCA at 08:06, 11 January 2023

OCA — Wed, 11 Jan 2023 08:06:11 GMT

←Older revision		Revision as of 08:06, 11 January 2023
Line 1:		Line 1:

	==Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog==		==Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog==
-	<StructureSection load='1in2' size='340' side='right'caption='[[1in2~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1in2' size='340' side='right'caption='[[1in2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=~~LNK~~:~~PENTANE~~'>~~LNK~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=LNK:PENTANE'>LNK</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~ACE~~:~~ACETYL+GROUP~~'>~~ACE~~</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>~~	+
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</div></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [https://pdbe.org/1in2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [https://www.ebi.ac.uk/pdbsum/1in2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1in2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [https://pdbe.org/1in2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [https://www.ebi.ac.uk/pdbsum/1in2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1in2 ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baca, M]]	+	[[Category: Baca M]]
-	[[Category: Chen~~, Y M~~]]	+	[[Category: Chen YM]]
-	[[Category: Cochran~~, A G~~]]	+	[[Category: Cochran AG]]
-	[[Category: Deshayes, K]]	+	[[Category: Deshayes K]]
-	[[Category: Dubree, N]]	+	[[Category: Dubree N]]
-	[[Category: Jackson~~, D Y~~]]	+	[[Category: Jackson DY]]
-	[[Category: Lowman~~, H B~~]]	+	[[Category: Lowman HB]]
-	[[Category: Pisabarro~~, M T~~]]	+	[[Category: Pisabarro MT]]
-	[[Category: Quan, C]]	+	[[Category: Quan C]]
-	[[Category: Skelton~~, N J~~]]	+	[[Category: Skelton NJ]]
-	[[Category: Zobel, K]]	+	[[Category: Zobel K]]
-	~~[[Category: Antagonist]]~~	+
-	~~[[Category: Covalently constrained helix~~]]	+

OCA at 07:46, 7 April 2021

OCA — Wed, 07 Apr 2021 07:46:07 GMT

←Older revision		Revision as of 07:46, 7 April 2021
Line 3:		Line 3:
	<StructureSection load='1in2' size='340' side='right'caption='[[1in2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1in2' size='340' side='right'caption='[[1in2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LNK:PENTANE'>LNK</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LNK:PENTANE'>LNK</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [~~http~~://pdbe.org/1in2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1in2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1in2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [https://pdbe.org/1in2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [https://www.ebi.ac.uk/pdbsum/1in2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1in2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:53, 3 July 2019

OCA — Wed, 03 Jul 2019 07:53:41 GMT

←Older revision		Revision as of 07:53, 3 July 2019
Line 1:		Line 1:

	==Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog==		==Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog==
-	<StructureSection load='1in2' size='340' side='right' caption='[[1in2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1in2' size='340' side='right'caption='[[1in2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Baca, M]]		[[Category: Baca, M]]
	[[Category: Chen, Y M]]		[[Category: Chen, Y M]]

OCA at 10:52, 27 September 2017

OCA — Wed, 27 Sep 2017 10:52:43 GMT

←Older revision		Revision as of 10:52, 27 September 2017
Line 1:		Line 1:
		+
	==Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog==		==Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog==
	<StructureSection load='1in2' size='340' side='right' caption='[[1in2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1in2' size='340' side='right' caption='[[1in2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [http://pdbe.org/1in2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [http://pdbe.org/1in2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1in2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:22, 9 September 2015

OCA — Wed, 09 Sep 2015 23:22:19 GMT

←Older revision		Revision as of 23:22, 9 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [http://pdbe.org/1in2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1in2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:49, 2 January 2015

OCA — Fri, 02 Jan 2015 09:49:45 GMT

←Older revision		Revision as of 09:49, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LNK:PENTANE'>LNK</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LNK:PENTANE'>LNK</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baca, M.]]	+	[[Category: Baca, M]]
-	[[Category: Chen, Y M.]]	+	[[Category: Chen, Y M]]
-	[[Category: Cochran, A G.]]	+	[[Category: Cochran, A G]]
-	[[Category: Deshayes, K.]]	+	[[Category: Deshayes, K]]
-	[[Category: Dubree, N.]]	+	[[Category: Dubree, N]]
-	[[Category: Jackson, D Y.]]	+	[[Category: Jackson, D Y]]
-	[[Category: Lowman, H B.]]	+	[[Category: Lowman, H B]]
-	[[Category: Pisabarro, M T.]]	+	[[Category: Pisabarro, M T]]
-	[[Category: Quan, C.]]	+	[[Category: Quan, C]]
-	[[Category: Skelton, N J.]]	+	[[Category: Skelton, N J]]
-	[[Category: Zobel, K.]]	+	[[Category: Zobel, K]]
	[[Category: Antagonist]]		[[Category: Antagonist]]
	[[Category: Covalently constrained helix]]		[[Category: Covalently constrained helix]]

OCA: Protected "1in2" [edit=sysop:move=sysop]

OCA — Sun, 08 Jun 2014 05:52:35 GMT

Protected "1in2" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 8 June 2014

OCA at 05:52, 8 June 2014

OCA — Sun, 08 Jun 2014 05:52:34 GMT

←Older revision		Revision as of 05:52, 8 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog==
-	[[~~Image:~~1in2.~~png~~\|~~left~~\|~~200px~~]]	+	<StructureSection load='1in2' size='340' side='right' caption='[[1in2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1in2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IN2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LNK:PENTANE'>LNK</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1imw\|1imw]], [[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1in2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1in2 RCSB], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Highly structured, peptide antagonists of the interaction between insulin-like growth factor 1 (IGF-I) and IGF binding protein 1 (IGFBP-1) have recently been discovered by phage display of naive peptide libraries [Lowman, H. B., et al. (1998) Biochemistry 37, 8870--8878]. We now report a detailed analysis of the features of this turn-helix peptide motif that are necessary for IGFBP-1 binding and structural integrity. Further rounds of phage randomization indicate the importance of residues contributing to a hydrophobic patch on one face of the helix. Alanine-scanning substitutions confirm that the hydrophobic residues are necessary for binding. However, structural analysis by NMR spectroscopy indicates that some of these analogues are less well folded. Structured, high-affinity analogues that lack the disulfide bond were prepared by introducing a covalent constraint between side chains at positions i and i + 7 or i + 8 within the helix. Analogues based on this scaffold demonstrate that a helical conformation is present in the bound state, and that hydrophobic side chains in this helix, and residues immediately preceding it, interact with IGFBP-1. By comparison of alanine scanning data for IGF-I and the turn-helix peptide, we propose a model for common surface features of these molecules that recognize IGFBP-1.

-	<!--	+	Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.,Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB Biochemistry. 2001 Jul 24;40(29):8487-98. PMID:11456486<ref>PMID:11456486</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_1in2"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_1in2\| PDB=1in2 \| SCENE= }}~~	+

-	~~===Peptide Antagonist~~ of ~~IGFBP1, (i,i+7) Covalently Restrained Analog===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_11456486}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 11456486 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_11456486}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA].~~	+
-		+
-	~~==Reference==~~	+
-	Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1., Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB, Biochemistry. 2001 Jul 24;40(29):8487-98. PMID:[http:/~~/www.ncbi.nlm.nih.gov/pubmed/11456486 11456486]~~	+
	[[Category: Baca, M.]]		[[Category: Baca, M.]]
	[[Category: Chen, Y M.]]		[[Category: Chen, Y M.]]
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	[[Category: Skelton, N J.]]		[[Category: Skelton, N J.]]
	[[Category: Zobel, K.]]		[[Category: Zobel, K.]]
		+	[[Category: Antagonist]]
	[[Category: Covalently constrained helix]]		[[Category: Covalently constrained helix]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:34:55 2008''

OCA at 10:34, 1 July 2008

OCA — Tue, 01 Jul 2008 10:34:59 GMT

←Older revision		Revision as of 10:34, 1 July 2008
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-	[[Image:1in2.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1in2.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1in2\| PDB=1in2 \| SCENE= }}		{{STRUCTURE_1in2\| PDB=1in2 \| SCENE= }}

-	~~'''~~Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog~~'''~~	+	===Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog===


-	~~==Overview==~~	+	<!--
-	~~Highly structured, peptide antagonists of the interaction between insulin~~-~~like growth factor 1 (IGF~~-~~I) and IGF binding protein 1 (IGFBP-1) have recently been discovered by phage display of naive peptide libraries [Lowman~~, ~~H. B.~~, ~~et al. (1998) Biochemistry 37, 8870--8878]. We now report a detailed analysis of~~ the ~~features of this turn-helix peptide motif that are necessary for IGFBP-1 binding and structural integrity. Further rounds of phage randomization indicate~~ the ~~importance of residues contributing to a hydrophobic patch~~ on ~~one face of the helix~~. ~~Alanine-scanning substitutions confirm that the hydrophobic residues are necessary for binding~~. ~~However~~, structural analysis by NMR spectroscopy indicates that some of these analogues are less well folded. Structured, high-affinity analogues that lack the disulfide bond were prepared by introducing a covalent constraint between side chains at positions i and i + 7 or i + 8 within the helix. Analogues based on this scaffold demonstrate that a helical conformation is ~~present in~~ the ~~bound state, and that hydrophobic side chains in this helix, and residues immediately preceding it, interact with IGFBP-1~~. ~~By comparison of alanine scanning data for IGF~~-~~I and the turn~~-~~helix peptide, we propose a model for common surface features of these molecules that recognize IGFBP-1.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_11456486}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11456486 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11456486}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA].

	==Reference==		==Reference==
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	[[Category: Zobel, K.]]		[[Category: Zobel, K.]]
	[[Category: Covalently constrained helix]]		[[Category: Covalently constrained helix]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:10:32 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:34:55 2008''

OCA at 17:10, 2 May 2008

OCA — Fri, 02 May 2008 17:10:34 GMT

←Older revision		Revision as of 17:10, 2 May 2008
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	[[Image:1in2.jpg\|left\|200px]]		[[Image:1in2.jpg\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 1in2 \|SIZE=350\|CAPTION=~~ <~~scene name='initialview01'>1in2</scene>~~	+	The line below this paragraph, containing "STRUCTURE_1in2", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>~~, ~~<scene name='pdbligand=LNK:PENTANE'>LNK</scene>~~, ~~<scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE=~~	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_1in2\| PDB=1in2 \| SCENE= }}
-	~~\|RELATEDENTRY=[[1imw\|1imw]]~~, ~~[[1in3\|1in3]], [[1gje\|1gje]], [[1gjf\|1gjf]], [[1gjg\|1gjg]]~~	+
-	~~\|RESOURCES=<span class='plainlinks'>[http://oca~~.~~weizmann.ac.il/oca~~-~~docs/fgij/fg.htm?mol=1in2 FirstGlance], [http://oca.weizmann.ac.il/oca~~-~~bin/ocaids?id~~=1in2 ~~OCA], [http://www.ebi.ac.uk/pdbsum/1in2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId~~=~~1in2 RCSB]</span>~~	+
-	}}	+

	'''Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog'''		'''Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog'''
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	==About this Structure==		==About this Structure==
-	~~1IN2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA].	+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IN2 OCA].

	==Reference==		==Reference==
	Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1., Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB, Biochemistry. 2001 Jul 24;40(29):8487-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11456486 11456486]		Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1., Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB, Biochemistry. 2001 Jul 24;40(29):8487-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11456486 11456486]
-	[[Category: Protein complex]]
	[[Category: Baca, M.]]		[[Category: Baca, M.]]
	[[Category: Chen, Y M.]]		[[Category: Chen, Y M.]]
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	[[Category: Skelton, N J.]]		[[Category: Skelton, N J.]]
	[[Category: Zobel, K.]]		[[Category: Zobel, K.]]
-	[[Category: ~~covalently~~ constrained helix]]	+	[[Category: Covalently constrained helix]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:10:32 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 30 21~~:21:58 2008''	+