1isj - Revision history

OCA at 23:36, 27 December 2023

OCA — Wed, 27 Dec 2023 23:36:23 GMT

←Older revision		Revision as of 23:36, 27 December 2023
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	<StructureSection load='1isj' size='340' side='right'caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1isj' size='340' side='right'caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NMN:BETA~~-~~NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [https://pdbe.org/1isj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [https://www.ebi.ac.uk/pdbsum/1isj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1isj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [https://pdbe.org/1isj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [https://www.ebi.ac.uk/pdbsum/1isj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1isj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BST1_HUMAN BST1_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.	+	[https://www.uniprot.org/uniprot/BST1_HUMAN BST1_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ariyoshi, M]]	+	[[Category: Ariyoshi M]]
-	[[Category: Hirano, T]]	+	[[Category: Hirano T]]
-	[[Category: Ishihara, K]]	+	[[Category: Ishihara K]]
-	[[Category: Jingami, H]]	+	[[Category: Jingami H]]
-	[[Category: Morikawa, K]]	+	[[Category: Morikawa K]]
-	[[Category: Yamamoto-Katayama, S]]	+	[[Category: Yamamoto-Katayama S]]
-	~~[[Category: Adp ribosyl cyclase]]~~	+
-	~~[[Category: Cn]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nad glycohydrolase]]~~	+
-	~~[[Category: Nmn~~]]	+

OCA at 11:04, 4 August 2021

OCA — Wed, 04 Aug 2021 11:04:53 GMT

←Older revision		Revision as of 11:04, 4 August 2021
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	<StructureSection load='1isj' size='340' side='right'caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1isj' size='340' side='right'caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~NAG~~:N-~~ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~NMN~~:~~BETA~~-~~NICOTINAMIDE+RIBOSE+MONOPHOSPHATE~~'>~~NMN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [~~http~~://pdbe.org/1isj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1isj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1isj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [https://pdbe.org/1isj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [https://www.ebi.ac.uk/pdbsum/1isj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1isj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BST1_HUMAN BST1_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.	+	[[https://www.uniprot.org/uniprot/BST1_HUMAN BST1_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:24, 30 October 2019

OCA — Wed, 30 Oct 2019 10:24:07 GMT

←Older revision		Revision as of 10:24, 30 October 2019
Line 1:		Line 1:

	==Crystal Structure Analysis of BST-1/CD157 complexed with NMN==		==Crystal Structure Analysis of BST-1/CD157 complexed with NMN==
-	<StructureSection load='1isj' size='340' side='right' caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1isj' size='340' side='right'caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ariyoshi, M]]		[[Category: Ariyoshi, M]]
	[[Category: Hirano, T]]		[[Category: Hirano, T]]

OCA at 09:08, 17 January 2018

OCA — Wed, 17 Jan 2018 09:08:05 GMT

←Older revision		Revision as of 09:08, 17 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure Analysis of BST-1/CD157 complexed with NMN==		==Crystal Structure Analysis of BST-1/CD157 complexed with NMN==
	<StructureSection load='1isj' size='340' side='right' caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1isj' size='340' side='right' caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~NMN~~:~~BETA~~-~~NICOTINAMIDE+RIBOSE+MONOPHOSPHATE~~'>~~NMN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D~~-~~GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [http://pdbe.org/1isj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [http://www.ebi.ac.uk/pdbsum/1isj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [http://pdbe.org/1isj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [http://www.ebi.ac.uk/pdbsum/1isj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1isj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/1isj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/1isj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:27, 7 February 2016

OCA — Sun, 07 Feb 2016 15:27:24 GMT

←Older revision		Revision as of 15:27, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1isj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:47, 10 September 2015

OCA — Thu, 10 Sep 2015 02:47:37 GMT

←Older revision		Revision as of 02:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1isj' size='340' side='right' caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1isj' size='340' side='right' caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [http://www.ebi.ac.uk/pdbsum/1isj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [http://pdbe.org/1isj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [http://www.ebi.ac.uk/pdbsum/1isj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1isj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ariyoshi, M]]		[[Category: Ariyoshi, M]]
	[[Category: Hirano, T]]		[[Category: Hirano, T]]

OCA at 16:17, 24 December 2014

OCA — Wed, 24 Dec 2014 16:17:39 GMT

←Older revision		Revision as of 16:17, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [http://www.ebi.ac.uk/pdbsum/1isj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [http://www.ebi.ac.uk/pdbsum/1isj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BST1_HUMAN BST1_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ariyoshi, M.]]	+	[[Category: Ariyoshi, M]]
-	[[Category: Hirano, T.]]	+	[[Category: Hirano, T]]
-	[[Category: Ishihara, K.]]	+	[[Category: Ishihara, K]]
-	[[Category: Jingami, H.]]	+	[[Category: Jingami, H]]
-	[[Category: Morikawa, K.]]	+	[[Category: Morikawa, K]]
-	[[Category: Yamamoto-Katayama, S.]]	+	[[Category: Yamamoto-Katayama, S]]
	[[Category: Adp ribosyl cyclase]]		[[Category: Adp ribosyl cyclase]]
	[[Category: Cn]]		[[Category: Cn]]

OCA at 13:36, 28 September 2014

OCA — Sun, 28 Sep 2014 13:36:16 GMT

←Older revision		Revision as of 13:36, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1isj.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure Analysis of BST-1/CD157 complexed with NMN==
		+	<StructureSection load='1isj' size='340' side='right' caption='[[1isj]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ISJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isf\|1isf]], [[1isg\|1isg]], [[1ish\|1ish]], [[1isi\|1isi]], [[1ism\|1ism]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1isj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1isj RCSB], [http://www.ebi.ac.uk/pdbsum/1isj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/1isj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	cADPR is the novel second messenger that elicits calcium release from intracellular calcium stores and works independently of IP(3). In mammals, the ADP-ribosyl cyclase function is found in two membrane proteins, CD38 and BST-1/CD157. These enzymes, exposed extracellularly, bear cADPR hydrolase and NAD glycohydrolase activities. In spite of its functional importance, the structural basis of these enzymatic reactions remains elusive. We determined the crystal structures of the extracellular region of human BST-1 at atomic resolution in the free form and in complexes with five substrate analogues: nicotinamide, NMN, ATPgammaS, ethenoNADP, and ethenoNAD. The three-dimensional structural views of the reaction centre with these ligands revealed the mode of substrate binding and the catalytic mechanism of the multifunctional enzymatic reactions. In each catalytic cleft of the dimeric enzyme, substrates are recognized predominantly through van der Waals interactions with two tryptophan residues, and thereby the N-glycosidic bond of NAD is correctly exposed near a catalytic glutamate residue. Its carboxyl side-chain stabilizes the catalytic intermediate of the S(N)-1 type reaction. This conformation of the catalytic cleft also implies the mechanism of cyclization between the adenine base and the ribose. The three key residues are invariant among the sequences of BST-1, CD38, and Aplysia cyclase, and hence this substrate recognition mode and catalytic scheme appear to be common in the cyclase family.

-	~~{{STRUCTURE_1isj\| PDB=1isj \| SCENE= }}~~	+	Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.,Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K J Mol Biol. 2002 Feb 22;316(3):711-23. PMID:11866528<ref>PMID:11866528</ref>

-	~~===Crystal Structure Analysis of BST-1~~/~~CD157 complexed with NMN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11866528}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1isj]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011866528<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ariyoshi, M.]]		[[Category: Ariyoshi, M.]]

OCA: Protected "1isj" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 15:01:44 GMT

Protected "1isj" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 28 November 2012

OCA at 15:01, 28 November 2012

OCA — Wed, 28 Nov 2012 15:01:40 GMT

←Older revision		Revision as of 15:01, 28 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1isj.png\|left\|200px]]		[[Image:1isj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1isj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1isj\| PDB=1isj \| SCENE= }}		{{STRUCTURE_1isj\| PDB=1isj \| SCENE= }}

	===Crystal Structure Analysis of BST-1/CD157 complexed with NMN===		===Crystal Structure Analysis of BST-1/CD157 complexed with NMN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11866528}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11866528 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11866528}}		{{ABSTRACT_PUBMED_11866528}}

	==About this Structure==		==About this Structure==
-	~~1ISJ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA].	+	[[1isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11866528~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011866528</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ariyoshi, M.]]		[[Category: Ariyoshi, M.]]
Line 33:		Line 21:
	[[Category: Adp ribosyl cyclase]]		[[Category: Adp ribosyl cyclase]]
	[[Category: Cn]]		[[Category: Cn]]
		+	[[Category: Hydrolase]]
	[[Category: Nad glycohydrolase]]		[[Category: Nad glycohydrolase]]
	[[Category: Nmn]]		[[Category: Nmn]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:46:42 2009''