1iv1 - Revision history

OCA at 23:37, 27 December 2023

OCA — Wed, 27 Dec 2023 23:37:24 GMT

←Older revision		Revision as of 23:37, 27 December 2023
Line 3:		Line 3:
	<StructureSection load='1iv1' size='340' side='right'caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1iv1' size='340' side='right'caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1iv2\|1iv2]]~~, [[~~1iv3~~\|~~1iv3~~]]~~, [[1iv4\|1iv4]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.~~12 4.6.1.12] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [https://pdbe.org/1iv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [https://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [https://pdbe.org/1iv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [https://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref>	+	[https://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
-	[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kishida, H]]	+	[[Category: Thermus thermophilus]]
-	[[Category: Kuzuyama, T]]	+	[[Category: Kishida H]]
-	[[Category: Park, S Y]]	+	[[Category: Kuzuyama T]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Park S-Y]]
-	[[Category: Sirouzu, M]]	+	[[Category: Sirouzu M]]
-	[[Category: Tame~~, J R.H~~]]	+	[[Category: Tame JRH]]
-	[[Category: Terada, T]]	+	[[Category: Terada T]]
-	[[Category: Unzai, S]]	+	[[Category: Unzai S]]
-	[[Category: Wada, T]]	+	[[Category: Wada T]]
-	[[Category: Yokoyama, S]]	+	[[Category: Yokoyama S]]
-	~~[[Category: Isoprenoid]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Non-mevalonate]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Synthase~~]]	+

OCA at 11:06, 4 August 2021

OCA — Wed, 04 Aug 2021 11:06:10 GMT

←Older revision		Revision as of 11:06, 4 August 2021
Line 3:		Line 3:
	<StructureSection load='1iv1' size='340' side='right'caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1iv1' size='340' side='right'caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [~~http~~://pdbe.org/1iv1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv1 ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [https://pdbe.org/1iv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [https://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref>	+	[[https://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:34, 30 October 2019

OCA — Wed, 30 Oct 2019 10:34:36 GMT

←Older revision		Revision as of 10:34, 30 October 2019
Line 1:		Line 1:

	==Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase==		==Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase==
-	<StructureSection load='1iv1' size='340' side='right' caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='1iv1' size='340' side='right'caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1iv1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1iv1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[MECDP synthase 3D structures\|MECDP synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]		[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
	[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]		[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Kishida, H]]		[[Category: Kishida, H]]
	[[Category: Kuzuyama, T]]		[[Category: Kuzuyama, T]]

OCA at 09:20, 17 January 2018

OCA — Wed, 17 Jan 2018 09:20:44 GMT

←Older revision		Revision as of 09:20, 17 January 2018
Line 1:		Line 1:
		+
	==Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase==		==Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase==
	<StructureSection load='1iv1' size='340' side='right' caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1iv1' size='340' side='right' caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [http://pdbe.org/1iv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [http://pdbe.org/1iv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv1 ProSAT], [http://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/1iv1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/1iv1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1iv1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1iv1" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[MECDP synthase\|MECDP synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:33, 10 February 2016

OCA — Wed, 10 Feb 2016 05:33:27 GMT

←Older revision		Revision as of 05:33, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iv1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:51, 11 September 2015

OCA — Fri, 11 Sep 2015 05:51:43 GMT

←Older revision		Revision as of 05:51, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1iv1' size='340' side='right' caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1iv1' size='340' side='right' caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [http://pdbe.org/1iv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1iv1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
	[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]		[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
-	[[Category: Thermus thermophilus]]
	[[Category: Kishida, H]]		[[Category: Kishida, H]]
	[[Category: Kuzuyama, T]]		[[Category: Kuzuyama, T]]

OCA at 12:09, 25 December 2014

OCA — Thu, 25 Dec 2014 12:09:51 GMT

←Older revision		Revision as of 12:09, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]		[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Kishida, H.]]	+	[[Category: Kishida, H]]
-	[[Category: Kuzuyama, T.]]	+	[[Category: Kuzuyama, T]]
-	[[Category: Park, S Y.]]	+	[[Category: Park, S Y]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sirouzu, M.]]	+	[[Category: Sirouzu, M]]
-	[[Category: Tame, J R.H.]]	+	[[Category: Tame, J R.H]]
-	[[Category: Terada, T.]]	+	[[Category: Terada, T]]
-	[[Category: Unzai, S.]]	+	[[Category: Unzai, S]]
-	[[Category: Wada, T.]]	+	[[Category: Wada, T]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Isoprenoid]]		[[Category: Isoprenoid]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Non-mevalonate]]		[[Category: Non-mevalonate]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Synthase]]		[[Category: Synthase]]

OCA at 09:48, 28 September 2014

OCA — Sun, 28 Sep 2014 09:48:36 GMT

←Older revision		Revision as of 09:48, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1iv1.~~png~~\|~~left~~\|200px]]	+	==Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase==
		+	<StructureSection load='1iv1' size='340' side='right' caption='[[1iv1]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iv2\|1iv2]], [[1iv3\|1iv3]], [[1iv4\|1iv4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1iv1 TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/1iv1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Precursors for isoprenoid synthesis are essential in all organisms. These compounds are synthesized by one of two known routes: the well characterized mevalonate pathway or a recently discovered non-mevalonate route which is used in many bacteria and human pathogens. Since the second pathway is both vital and unlike any found in humans, enzymes catalysing reactions along this synthetic route are possible drug targets. The structure of one such enzyme from the thermophilic bacterium Thermus thermophilus has been solved to high resolution in the presence of substrate and with a substrate analogue. Enzyme co-crystallized with substrate shows only one product, cytosine monophosphate (CMP), in the active site. At the high resolution of the refinement (1.6 A) the positions and coordination of the magnesium ions in the active site are clearly seen.

-	~~{{STRUCTURE_1iv1\| PDB=1iv1 \| SCENE= }}~~	+	Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.,Kishida H, Wada T, Unzai S, Kuzuyama T, Takagi M, Terada T, Shirouzu M, Yokoyama S, Tame JR, Park SY Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):23-31. Epub 2002, Dec 19. PMID:12499535<ref>PMID:12499535</ref>

-	~~===Structure of 2C-Methyl-D-erythritol-2~~,~~4-cyclodiphosphate Synthase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_12499535}}~~	+	==See Also==
-		+	*[[MECDP synthase\|MECDP synthase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1iv1~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:012499535<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]		[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA: Protected "1iv1" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 15:15:21 GMT

Protected "1iv1" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:15, 28 November 2012

OCA at 15:15, 28 November 2012

OCA — Wed, 28 Nov 2012 15:15:17 GMT

←Older revision		Revision as of 15:15, 28 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1iv1.png\|left\|200px]]		[[Image:1iv1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1iv1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1iv1\| PDB=1iv1 \| SCENE= }}		{{STRUCTURE_1iv1\| PDB=1iv1 \| SCENE= }}

	===Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase===		===Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12499535}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12499535 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12499535}}		{{ABSTRACT_PUBMED_12499535}}

	==About this Structure==		==About this Structure==
-	~~1IV1~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA].	+	[[1iv1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12499535~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012499535</ref><references group="xtra"/>
	[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]		[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
Line 37:		Line 25:
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
	[[Category: Isoprenoid]]		[[Category: Isoprenoid]]
		+	[[Category: Lyase]]
	[[Category: Non-mevalonate]]		[[Category: Non-mevalonate]]
	[[Category: Riken structural genomics/proteomics initiative]]		[[Category: Riken structural genomics/proteomics initiative]]
Line 42:		Line 31:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Synthase]]		[[Category: Synthase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:48:55 2009''