1izp - Revision history

OCA at 23:39, 27 December 2023

OCA — Wed, 27 Dec 2023 23:39:53 GMT

←Older revision		Revision as of 23:39, 27 December 2023
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	<StructureSection load='1izp' size='340' side='right'caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1izp' size='340' side='right'caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZP FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1izq\|1izq]]~~, [[~~1izr~~\|~~1izr~~]]~~, [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1~~.27~~.5 ~~3.1.27.5] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [https://pdbe.org/1izp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [https://www.ebi.ac.uk/pdbsum/1izp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [https://pdbe.org/1izp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [https://www.ebi.ac.uk/pdbsum/1izp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>	+	[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pancreatic ribonuclease]]~~	+	[[Category: Chatani E]]
-	[[Category: Chatani, E]]	+	[[Category: Hayashi R]]
-	[[Category: Hayashi, R]]	+	[[Category: Kadonosono T]]
-	[[Category: Kadonosono, T]]	+	[[Category: Moriyama H]]
-	[[Category: Moriyama, H]]	+	[[Category: Ueki T]]
-	[[Category: Ueki, T]]	+
-	~~[[Category: Bovine pancrea]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ribonuclease]]~~	+
-	~~[[Category: Rnase some~~]]	+

OCA at 07:15, 14 April 2021

OCA — Wed, 14 Apr 2021 07:15:19 GMT

←Older revision		Revision as of 07:15, 14 April 2021
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	<StructureSection load='1izp' size='340' side='right'caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1izp' size='340' side='right'caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IZP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZP FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [~~http~~://pdbe.org/1izp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1izp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1izp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [https://pdbe.org/1izp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [https://www.ebi.ac.uk/pdbsum/1izp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>	+	[[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	*[[Temp\|Temp]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:26, 10 July 2019

OCA — Wed, 10 Jul 2019 07:26:19 GMT

←Older revision		Revision as of 07:26, 10 July 2019
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	==F46L mutant of bovine pancreatic ribonuclease A==		==F46L mutant of bovine pancreatic ribonuclease A==
-	<StructureSection load='1izp' size='340' side='right' caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1izp' size='340' side='right'caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZP FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
	[[Category: Chatani, E]]		[[Category: Chatani, E]]

OCA at 09:57, 4 October 2017

OCA — Wed, 04 Oct 2017 09:57:22 GMT

←Older revision		Revision as of 09:57, 4 October 2017
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		+
	==F46L mutant of bovine pancreatic ribonuclease A==		==F46L mutant of bovine pancreatic ribonuclease A==
	<StructureSection load='1izp' size='340' side='right' caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1izp' size='340' side='right' caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [http://pdbe.org/1izp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [http://www.ebi.ac.uk/pdbsum/1izp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [http://pdbe.org/1izp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [http://www.ebi.ac.uk/pdbsum/1izp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1izp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1izp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:20, 11 September 2015

OCA — Fri, 11 Sep 2015 21:20:06 GMT

←Older revision		Revision as of 21:20, 11 September 2015
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	<StructureSection load='1izp' size='340' side='right' caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1izp' size='340' side='right' caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZP FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [http://www.ebi.ac.uk/pdbsum/1izp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [http://pdbe.org/1izp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [http://www.ebi.ac.uk/pdbsum/1izp PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1izp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
	[[Category: Chatani, E]]		[[Category: Chatani, E]]

OCA at 09:20, 16 February 2015

OCA — Mon, 16 Feb 2015 09:20:29 GMT

←Older revision		Revision as of 09:20, 16 February 2015
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	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
-	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:55, 25 December 2014

OCA — Thu, 25 Dec 2014 19:55:40 GMT

←Older revision		Revision as of 19:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [http://www.ebi.ac.uk/pdbsum/1izp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [http://www.ebi.ac.uk/pdbsum/1izp PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
		+	*[[Temp\|Temp]]
		+	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 38:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
-	[[Category: Chatani, E.]]	+	[[Category: Chatani, E]]
-	[[Category: Hayashi, R.]]	+	[[Category: Hayashi, R]]
-	[[Category: Kadonosono, T.]]	+	[[Category: Kadonosono, T]]
-	[[Category: Moriyama, H.]]	+	[[Category: Moriyama, H]]
-	[[Category: Ueki, T.]]	+	[[Category: Ueki, T]]
	[[Category: Bovine pancrea]]		[[Category: Bovine pancrea]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ribonuclease]]		[[Category: Ribonuclease]]
	[[Category: Rnase some]]		[[Category: Rnase some]]

OCA at 09:48, 28 September 2014

OCA — Sun, 28 Sep 2014 09:48:04 GMT

←Older revision		Revision as of 09:48, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1izp.~~png~~\|~~left~~\|200px]]	+	==F46L mutant of bovine pancreatic ribonuclease A==
		+	<StructureSection load='1izp' size='340' side='right' caption='[[1izp]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izq\|1izq]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izp RCSB], [http://www.ebi.ac.uk/pdbsum/1izp PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Phe46 residue, located in the hydrophobic core of RNase A, was replaced with other hydrophobic residues, leucine, valine, or alanine, and their X-ray crystallographic structures were determined up to 1.50-1.80 A resolution in an attempt to examine the relationship between structural changes and conformational stability or folding kinetics. The backbone structure of F46L, F46V, and F46A was indistinguishable from that of the wild-type enzyme, retaining the correct active site structure. However, one water molecule was included in the hydrophobic core of F46A, forming two hydrogen bonds with the backbone peptide chain. The side chain of Met29 in F46V and F46A adopted two different conformations in an equal occupancy. A trapped water molecule and two conformations of Met29 represent changes that minimize the cavity volume. Nevertheless, the replacement of Phe46 with the above residues resulted in a marked decrease in both thermal stability and folding reaction. Thus, Phe46 ensures the thermal stability and the rapid and correct folding of RNase A by the role it plays in forming a highly packed, hydrophobic core.

-	~~{{STRUCTURE_1izp\| PDB=1izp \| SCENE= }}~~	+	Minimization of cavity size ensures protein stability and folding: structures of Phe46-replaced bovine pancreatic RNase A.,Kadonosono T, Chatani E, Hayashi R, Moriyama H, Ueki T Biochemistry. 2003 Sep 16;42(36):10651-8. PMID:12962489<ref>PMID:12962489</ref>

-	~~===F46L mutant~~ of ~~bovine pancreatic ribonuclease A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12962489}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1izp]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA].~~	+

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012962489<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]

OCA at 20:49, 20 October 2012

OCA — Sat, 20 Oct 2012 20:49:08 GMT

←Older revision		Revision as of 20:49, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1izp]] is a 1 chain structure ~~of [[Ribonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA].	+	[[1izp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZP OCA].

	==See Also==		==See Also==

OCA: Protected "1izp" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 11:43:14 GMT

Protected "1izp" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:43, 27 July 2012