1izq - Revision history

OCA at 07:13, 25 October 2023

OCA — Wed, 25 Oct 2023 07:13:20 GMT

←Older revision		Revision as of 07:13, 25 October 2023
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	<StructureSection load='1izq' size='340' side='right'caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1izq' size='340' side='right'caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1izp\|1izp]]~~, [[~~1izr~~\|~~1izr~~]]~~, [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.~~27.5 3.1.27.5] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [https://pdbe.org/1izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [https://www.ebi.ac.uk/pdbsum/1izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [https://pdbe.org/1izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [https://www.ebi.ac.uk/pdbsum/1izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>	+	[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pancreatic ribonuclease]]~~	+	[[Category: Chatani E]]
-	[[Category: Chatani, E]]	+	[[Category: Hayashi R]]
-	[[Category: Hayashi, R]]	+	[[Category: Kadonosono T]]
-	[[Category: Kadonosono, T]]	+	[[Category: Moriyama H]]
-	[[Category: Moriyama, H]]	+	[[Category: Ueki T]]
-	[[Category: Ueki, T]]	+
-	~~[[Category: Bovine pancrea]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ribonuclease]]~~	+
-	~~[[Category: Rnase some~~]]	+

OCA at 11:08, 4 August 2021

OCA — Wed, 04 Aug 2021 11:08:35 GMT

←Older revision		Revision as of 11:08, 4 August 2021
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	<StructureSection load='1izq' size='340' side='right'caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1izq' size='340' side='right'caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [~~http~~://pdbe.org/1izq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1izq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1izq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [https://pdbe.org/1izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [https://www.ebi.ac.uk/pdbsum/1izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>	+	[[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	*[[Temp\|Temp]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:29, 30 October 2019

OCA — Wed, 30 Oct 2019 10:29:39 GMT

←Older revision		Revision as of 10:29, 30 October 2019
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	==F46V mutant of bovine pancreatic ribonuclease A==		==F46V mutant of bovine pancreatic ribonuclease A==
-	<StructureSection load='1izq' size='340' side='right' caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1izq' size='340' side='right'caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
	[[Category: Chatani, E]]		[[Category: Chatani, E]]

OCA at 09:12, 17 January 2018

OCA — Wed, 17 Jan 2018 09:12:58 GMT

←Older revision		Revision as of 09:12, 17 January 2018
Line 1:		Line 1:
		+
	==F46V mutant of bovine pancreatic ribonuclease A==		==F46V mutant of bovine pancreatic ribonuclease A==
	<StructureSection load='1izq' size='340' side='right' caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1izq' size='340' side='right' caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [http://pdbe.org/1izq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [http://www.ebi.ac.uk/pdbsum/1izq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [http://pdbe.org/1izq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [http://www.ebi.ac.uk/pdbsum/1izq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1izq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	== References ==		== References ==

OCA at 03:28, 7 February 2016

OCA — Sun, 07 Feb 2016 03:28:11 GMT

←Older revision		Revision as of 03:28, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1izq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:15, 9 September 2015

OCA — Wed, 09 Sep 2015 21:15:53 GMT

←Older revision		Revision as of 21:15, 9 September 2015
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	<StructureSection load='1izq' size='340' side='right' caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1izq' size='340' side='right' caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [http://www.ebi.ac.uk/pdbsum/1izq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [http://pdbe.org/1izq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [http://www.ebi.ac.uk/pdbsum/1izq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1izq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
	[[Category: Chatani, E]]		[[Category: Chatani, E]]

OCA at 08:25, 16 February 2015

OCA — Mon, 16 Feb 2015 08:25:45 GMT

←Older revision		Revision as of 08:25, 16 February 2015
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	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
-	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:29, 24 December 2014

OCA — Wed, 24 Dec 2014 07:29:52 GMT

←Older revision		Revision as of 07:29, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [http://www.ebi.ac.uk/pdbsum/1izq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [http://www.ebi.ac.uk/pdbsum/1izq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
		+	*[[Temp\|Temp]]
		+	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 38:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
-	[[Category: Chatani, E.]]	+	[[Category: Chatani, E]]
-	[[Category: Hayashi, R.]]	+	[[Category: Hayashi, R]]
-	[[Category: Kadonosono, T.]]	+	[[Category: Kadonosono, T]]
-	[[Category: Moriyama, H.]]	+	[[Category: Moriyama, H]]
-	[[Category: Ueki, T.]]	+	[[Category: Ueki, T]]
	[[Category: Bovine pancrea]]		[[Category: Bovine pancrea]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ribonuclease]]		[[Category: Ribonuclease]]
	[[Category: Rnase some]]		[[Category: Rnase some]]

OCA at 08:58, 28 September 2014

OCA — Sun, 28 Sep 2014 08:58:25 GMT

←Older revision		Revision as of 08:58, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1izq.~~png~~\|~~left~~\|200px]]	+	==F46V mutant of bovine pancreatic ribonuclease A==
		+	<StructureSection load='1izq' size='340' side='right' caption='[[1izq]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1izp\|1izp]], [[1izr\|1izr]], [[1izs\|1izs]], [[1izt\|1izt]], [[1izu\|1izu]], [[1izv\|1izv]], [[1izw\|1izw]], [[1izx\|1izx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izq RCSB], [http://www.ebi.ac.uk/pdbsum/1izq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Phe46 residue, located in the hydrophobic core of RNase A, was replaced with other hydrophobic residues, leucine, valine, or alanine, and their X-ray crystallographic structures were determined up to 1.50-1.80 A resolution in an attempt to examine the relationship between structural changes and conformational stability or folding kinetics. The backbone structure of F46L, F46V, and F46A was indistinguishable from that of the wild-type enzyme, retaining the correct active site structure. However, one water molecule was included in the hydrophobic core of F46A, forming two hydrogen bonds with the backbone peptide chain. The side chain of Met29 in F46V and F46A adopted two different conformations in an equal occupancy. A trapped water molecule and two conformations of Met29 represent changes that minimize the cavity volume. Nevertheless, the replacement of Phe46 with the above residues resulted in a marked decrease in both thermal stability and folding reaction. Thus, Phe46 ensures the thermal stability and the rapid and correct folding of RNase A by the role it plays in forming a highly packed, hydrophobic core.

-	~~{{STRUCTURE_1izq\| PDB=1izq \| SCENE= }}~~	+	Minimization of cavity size ensures protein stability and folding: structures of Phe46-replaced bovine pancreatic RNase A.,Kadonosono T, Chatani E, Hayashi R, Moriyama H, Ueki T Biochemistry. 2003 Sep 16;42(36):10651-8. PMID:12962489<ref>PMID:12962489</ref>

-	~~===F46V mutant~~ of ~~bovine pancreatic ribonuclease A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12962489}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1izq]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA].~~	+

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012962489<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]

OCA at 05:28, 20 October 2012

OCA — Sat, 20 Oct 2012 05:28:04 GMT

←Older revision		Revision as of 05:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1izq]] is a 1 chain structure ~~of [[Ribonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA].	+	[[1izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZQ OCA].

	==See Also==		==See Also==