1j19 - Revision history

OCA at 07:14, 25 October 2023

OCA — Wed, 25 Oct 2023 07:14:04 GMT

←Older revision		Revision as of 07:14, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1j19' size='340' side='right'caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1j19' size='340' side='right'caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J19 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1gc6\|1gc6]]~~, [[~~1gc7~~\|~~1gc7~~]]~~, [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [https://pdbe.org/1j19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [https://www.ebi.ac.uk/pdbsum/1j19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j19 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [https://pdbe.org/1j19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [https://www.ebi.ac.uk/pdbsum/1j19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[https://www.uniprot.org/uniprot/ICAM2_MOUSE ICAM2_MOUSE]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.	+	[https://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hakoshima, T]]	+	[[Category: Hakoshima T]]
-	[[Category: Hamada, K]]	+	[[Category: Hamada K]]
-	[[Category: Shimizu, T]]	+	[[Category: Shimizu T]]
-	[[Category: Tsukita, S]]	+	[[Category: Tsukita S]]
-	[[Category: Yonemura, S]]	+	[[Category: Yonemura S]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Protein-peptide complex~~]]	+

OCA at 07:15, 14 April 2021

OCA — Wed, 14 Apr 2021 07:15:41 GMT

←Older revision		Revision as of 07:15, 14 April 2021
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	<StructureSection load='1j19' size='340' side='right'caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1j19' size='340' side='right'caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1J19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J19 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [~~http~~://pdbe.org/1j19 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1j19 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1j19 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [https://pdbe.org/1j19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [https://www.ebi.ac.uk/pdbsum/1j19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[~~http~~://www.uniprot.org/uniprot/ICAM2_MOUSE ICAM2_MOUSE]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.	+	[[https://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[https://www.uniprot.org/uniprot/ICAM2_MOUSE ICAM2_MOUSE]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:20, 10 July 2019

OCA — Wed, 10 Jul 2019 07:20:28 GMT

←Older revision		Revision as of 07:20, 10 July 2019
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	==Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide==		==Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide==
-	<StructureSection load='1j19' size='340' side='right' caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1j19' size='340' side='right'caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/1j19_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/1j19_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1j19" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1j19" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Radixin\|Radixin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]

OCA at 09:50, 4 October 2017

OCA — Wed, 04 Oct 2017 09:50:56 GMT

←Older revision		Revision as of 09:50, 4 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide==		==Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide==
	<StructureSection load='1j19' size='340' side='right' caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1j19' size='340' side='right' caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [http://pdbe.org/1j19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [http://www.ebi.ac.uk/pdbsum/1j19 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [http://pdbe.org/1j19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [http://www.ebi.ac.uk/pdbsum/1j19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j19 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:55, 11 September 2015

OCA — Fri, 11 Sep 2015 17:55:17 GMT

←Older revision		Revision as of 17:55, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1j19' size='340' side='right' caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1j19' size='340' side='right' caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [http://www.ebi.ac.uk/pdbsum/1j19 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [http://pdbe.org/1j19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [http://www.ebi.ac.uk/pdbsum/1j19 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1j19" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]
	[[Category: Hamada, K]]		[[Category: Hamada, K]]

OCA at 19:52, 25 December 2014

OCA — Thu, 25 Dec 2014 19:52:06 GMT

←Older revision		Revision as of 19:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [http://www.ebi.ac.uk/pdbsum/1j19 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [http://www.ebi.ac.uk/pdbsum/1j19 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[http://www.uniprot.org/uniprot/ICAM2_MOUSE ICAM2_MOUSE]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Hakoshima, T.]]	+	[[Category: Hakoshima, T]]
-	[[Category: Hamada, K.]]	+	[[Category: Hamada, K]]
-	[[Category: Shimizu, T.]]	+	[[Category: Shimizu, T]]
-	[[Category: Tsukita, S.]]	+	[[Category: Tsukita, S]]
-	[[Category: Yonemura, S.]]	+	[[Category: Yonemura, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]

OCA at 09:41, 28 September 2014

OCA — Sun, 28 Sep 2014 09:41:51 GMT

←Older revision		Revision as of 09:41, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1j19.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide==
		+	<StructureSection load='1j19' size='340' side='right' caption='[[1j19]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J19 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gc6\|1gc6]], [[1gc7\|1gc7]], [[1ef1\|1ef1]], [[1e5w\|1e5w]], [[1isn\|1isn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j19 RCSB], [http://www.ebi.ac.uk/pdbsum/1j19 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/1j19_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ERM (ezrin/radixin/moesin) proteins recognize the cytoplasmic domains of adhesion molecules in the formation of the membrane-associated cytoskeleton. Here we report the crystal structure of the radixin FERM (4.1 and ERM) domain complexed with the ICAM-2 cytoplasmic peptide. The non-polar region of the ICAM-2 peptide contains the RxxTYxVxxA sequence motif to form a beta-strand followed by a short 3(10)-helix. It binds the groove of the phosphotyrosine-binding (PTB)-like subdomain C mediated by a beta-beta association and several side-chain interactions. The binding mode of the ICAM-2 peptide to the FERM domain is distinct from that of the NPxY motif-containing peptide binding to the canonical PTB domain. Mutation analyses based on the crystal structure reveal the determinant elements of recognition and provide the first insights into the physical link between adhesion molecules and ERM proteins.

-	~~{{STRUCTURE_1j19\| PDB=1j19 \| SCENE= }}~~	+	Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex.,Hamada K, Shimizu T, Yonemura S, Tsukita S, Tsukita S, Hakoshima T EMBO J. 2003 Feb 3;22(3):502-14. PMID:12554651<ref>PMID:12554651</ref>

-	~~===Crystal structure~~ of the ~~radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12554651}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1j19]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012554651<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]

OCA: Protected "1j19" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 15:05:10 GMT

Protected "1j19" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:05, 28 November 2012

OCA at 15:05, 28 November 2012

OCA — Wed, 28 Nov 2012 15:05:06 GMT

←Older revision		Revision as of 15:05, 28 November 2012
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-	{{Seed}}
	[[Image:1j19.png\|left\|200px]]		[[Image:1j19.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1j19\| PDB=1j19 \| SCENE= }}		{{STRUCTURE_1j19\| PDB=1j19 \| SCENE= }}

	===Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide===		===Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12554651}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12554651 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12554651}}		{{ABSTRACT_PUBMED_12554651}}

	==About this Structure==		==About this Structure==
-	~~1J19~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA].	+	[[1j19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12554651~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012554651</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]
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	[[Category: Tsukita, S.]]		[[Category: Tsukita, S.]]
	[[Category: Yonemura, S.]]		[[Category: Yonemura, S.]]
		+	[[Category: Cell adhesion]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:15:34 2009''

OCA at 03:15, 18 February 2009

OCA — Wed, 18 Feb 2009 03:15:37 GMT

←Older revision		Revision as of 03:15, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1J19 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA].	+	1J19 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J19 OCA].

	==Reference==		==Reference==
-	Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex., Hamada K, Shimizu T, Yonemura S, Tsukita S, Tsukita S, Hakoshima T, EMBO J. 2003 Feb 3;22(3):502-14. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12554651 12554651]~~	+	<ref group="xtra">PMID:12554651</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Protein complex]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]
	[[Category: Hamada, K.]]		[[Category: Hamada, K.]]
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	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 14~~:20:~~41 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:15:34 2009''