1jhu - Revision history

OCA at 08:41, 16 August 2023

OCA — Wed, 16 Aug 2023 08:41:03 GMT

←Older revision		Revision as of 08:41, 16 August 2023
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	<StructureSection load='1jhu' size='340' side='right'caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jhu' size='340' side='right'caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PCR:P~~-~~CRESOL'>PCR</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [https://pdbe.org/1jhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [https://www.ebi.ac.uk/pdbsum/1jhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [https://pdbe.org/1jhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [https://www.ebi.ac.uk/pdbsum/1jhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/COBT_SALTY COBT_SALTY]] Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).	+	[https://www.uniprot.org/uniprot/COBT_SALTY COBT_SALTY] Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus cholerae-suis smith 1894]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase~~]]	+	[[Category: Salmonella enterica]]
-	[[Category: Cheong~~, C G~~]]	+	[[Category: Cheong CG]]
-	[[Category: Escalante-Semerena, J]]	+	[[Category: Escalante-Semerena J]]
-	[[Category: Rayment, I]]	+	[[Category: Rayment I]]
-	~~[[Category: Cobalamin biosynthesis]]~~	+
-	~~[[Category: Cobamide]]~~	+
-	~~[[Category: Cobt]]~~	+
-	~~[[Category: Lower ligand]]~~	+
-	~~[[Category: N1-alpha-phosphoribosyltransferase]]~~	+
-	~~[[Category: Nn:dbi prt]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:40, 11 August 2021

OCA — Wed, 11 Aug 2021 06:40:51 GMT

←Older revision		Revision as of 06:40, 11 August 2021
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	<StructureSection load='1jhu' size='340' side='right'caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jhu' size='340' side='right'caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JHU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [~~http~~://pdbe.org/1jhu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jhu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [https://pdbe.org/1jhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [https://www.ebi.ac.uk/pdbsum/1jhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/COBT_SALTY COBT_SALTY]] Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).	+	[[https://www.uniprot.org/uniprot/COBT_SALTY COBT_SALTY]] Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]	+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:08, 6 November 2019

OCA — Wed, 06 Nov 2019 09:08:45 GMT

←Older revision		Revision as of 09:08, 6 November 2019
Line 1:		Line 1:

	==Three-dimensional Structure of CobT in Complex with p-cresol==		==Three-dimensional Structure of CobT in Complex with p-cresol==
-	<StructureSection load='1jhu' size='340' side='right' caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1jhu' size='340' side='right'caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHU FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1jhu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jhu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus cholerae-suis smith 1894]]		[[Category: Bacillus cholerae-suis smith 1894]]
		+	[[Category: Large Structures]]
	[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]		[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]
	[[Category: Cheong, C G]]		[[Category: Cheong, C G]]

OCA at 08:45, 17 January 2018

OCA — Wed, 17 Jan 2018 08:45:57 GMT

←Older revision		Revision as of 08:45, 17 January 2018
Line 1:		Line 1:
		+
	==Three-dimensional Structure of CobT in Complex with p-cresol==		==Three-dimensional Structure of CobT in Complex with p-cresol==
	<StructureSection load='1jhu' size='340' side='right' caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jhu' size='340' side='right' caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [http://pdbe.org/1jhu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [http://www.ebi.ac.uk/pdbsum/1jhu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [http://pdbe.org/1jhu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [http://www.ebi.ac.uk/pdbsum/1jhu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jhu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jhu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1jhu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jhu" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:54, 8 February 2016

OCA — Mon, 08 Feb 2016 10:54:28 GMT

←Older revision		Revision as of 10:54, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jhu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:51, 10 September 2015

OCA — Thu, 10 Sep 2015 10:51:01 GMT

←Older revision		Revision as of 10:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1jhu' size='340' side='right' caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jhu' size='340' side='right' caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmonella_enterica Salmonella enterica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [http://www.ebi.ac.uk/pdbsum/1jhu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [http://pdbe.org/1jhu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [http://www.ebi.ac.uk/pdbsum/1jhu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jhu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus cholerae-suis smith 1894]]
	[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]		[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]
-	[[Category: Salmonella enterica]]
	[[Category: Cheong, C G]]		[[Category: Cheong, C G]]
	[[Category: Escalante-Semerena, J]]		[[Category: Escalante-Semerena, J]]

OCA at 22:49, 24 December 2014

OCA — Wed, 24 Dec 2014 22:49:58 GMT

←Older revision		Revision as of 22:49, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [http://www.ebi.ac.uk/pdbsum/1jhu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [http://www.ebi.ac.uk/pdbsum/1jhu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/COBT_SALTY COBT_SALTY]] Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]		[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]
	[[Category: Salmonella enterica]]		[[Category: Salmonella enterica]]
-	[[Category: Cheong, C G.]]	+	[[Category: Cheong, C G]]
-	[[Category: Escalante-Semerena, J.]]	+	[[Category: Escalante-Semerena, J]]
-	[[Category: Rayment, I.]]	+	[[Category: Rayment, I]]
	[[Category: Cobalamin biosynthesis]]		[[Category: Cobalamin biosynthesis]]
	[[Category: Cobamide]]		[[Category: Cobamide]]

OCA at 09:15, 28 September 2014

OCA — Sun, 28 Sep 2014 09:15:56 GMT

←Older revision		Revision as of 09:15, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jhu.~~png~~\|~~left~~\|200px]]	+	==Three-dimensional Structure of CobT in Complex with p-cresol==
		+	<StructureSection load='1jhu' size='340' side='right' caption='[[1jhu]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JHU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCR:P-CRESOL'>PCR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0s\|1d0s]], [[1d0v\|1d0v]], [[1jha\|1jha]], [[1jhx\|1jhx]], [[1jhq\|1jhq]], [[1jh8\|1jh8]], [[1jhy\|1jhy]], [[1jhp\|1jhp]], [[1jhv\|1jhv]], [[1jhr\|1jhr]], [[1jhm\|1jhm]], [[1jho\|1jho]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide--dimethylbenzimidazole_phosphoribosyltransferase Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.21 2.4.2.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jhu RCSB], [http://www.ebi.ac.uk/pdbsum/1jhu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jhu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole, a key component of the lower ligand of cobalamin. Surprisingly, CobT can phosphoribosylate a wide range of aromatic substrates, giving rise to a wide variety of lower ligands in cobamides. To understand the molecular basis for this lack of substrate specificity, the x-ray structures of CobT complexed with adenine, 5-methylbenzimidazole, 5-methoxybenzimidazole, p-cresol, and phenol were determined. Furthermore, adenine, 5-methylbenzimidazole, 5-methoxybenzimidazole, and 2-hydroxypurine were observed to react with NaMN within the crystal lattice and undergo the phosphoribosyl transfer reaction to form product. Significantly, the stereochemistries of all products are identical to those found in vivo. Interestingly, p-cresol and phenol, which are the lower ligand in Sporomusa ovata, bound to CobT but did not react with NaMN. This study provides a structural explanation for how CobT can phosphoribosylate most of the commonly observed lower ligands found in cobamides with the exception of the phenolic lower ligands observed in S. ovata. This is accomplished with minor conformational changes in the side chains that constitute the 5,6-dimethylbenzimidazole binding site. These investigations are consistent with the implication that the nature of the lower ligand is controlled by metabolic factors rather by the specificity of the phosphoribosyltransferase.

-	~~{{STRUCTURE_1jhu\| PDB=1jhu \| SCENE= }}~~	+	Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica.,Cheong CG, Escalante-Semerena JC, Rayment I J Biol Chem. 2001 Oct 5;276(40):37612-20. Epub 2001 Jul 5. PMID:11441022<ref>PMID:11441022</ref>

-	~~===Three-dimensional Structure~~ of ~~CobT in Complex with p-cresol===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11441022}}~~	+	==See Also==
-		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1jhu~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011441022<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]		[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]
	[[Category: Salmonella enterica]]		[[Category: Salmonella enterica]]

OCA: Protected "1jhu" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:21:52 GMT

Protected "1jhu" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:21, 5 December 2012

OCA at 11:21, 5 December 2012

OCA — Wed, 05 Dec 2012 11:21:47 GMT

←Older revision		Revision as of 11:21, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jhu.png\|left\|200px]]		[[Image:1jhu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jhu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jhu\| PDB=1jhu \| SCENE= }}		{{STRUCTURE_1jhu\| PDB=1jhu \| SCENE= }}

	===Three-dimensional Structure of CobT in Complex with p-cresol===		===Three-dimensional Structure of CobT in Complex with p-cresol===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11441022}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11441022 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11441022}}		{{ABSTRACT_PUBMED_11441022}}

	==About this Structure==		==About this Structure==
-	~~1JHU~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA].	+	[[1jhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11441022~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011441022</ref><references group="xtra"/>
	[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]		[[Category: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase]]
	[[Category: Salmonella enterica]]		[[Category: Salmonella enterica]]
Line 35:		Line 23:
	[[Category: N1-alpha-phosphoribosyltransferase]]		[[Category: N1-alpha-phosphoribosyltransferase]]
	[[Category: Nn:dbi prt]]		[[Category: Nn:dbi prt]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 21:29:29 2009''~~	+