1jkr - Revision history

OCA at 08:42, 16 August 2023

OCA — Wed, 16 Aug 2023 08:42:12 GMT

←Older revision		Revision as of 08:42, 16 August 2023
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	<StructureSection load='1jkr' size='340' side='right'caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='1jkr' size='340' side='right'caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JKR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TRS:2-AMINO~~-2~~-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.28Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [https://pdbe.org/1jkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [https://www.ebi.ac.uk/pdbsum/1jkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jkr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [https://pdbe.org/1jkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [https://www.ebi.ac.uk/pdbsum/1jkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jkr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HIN_SALTY HIN_SALTY]] A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.	+	[https://www.uniprot.org/uniprot/HIN_SALTY HIN_SALTY] A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chiu, T K~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: ~~Dickerson, R E~~]]	+	[[Category: Chiu TK]]
-	[[Category: ~~Johnson, R C~~]]	+	[[Category: Dickerson RE]]
-	[[Category: ~~Sohn, C~~]]	+	[[Category: Johnson RC]]
-	[[Category: ~~Dna binding protein-dna complex]]~~	+	[[Category: Sohn C]]
-	~~[[Category: Hin recombinase]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: T11c mutant]]~~	+
-	~~[[Category: Water-mediated recognition~~]]	+

OCA at 06:42, 11 August 2021

OCA — Wed, 11 Aug 2021 06:42:01 GMT

←Older revision		Revision as of 06:42, 11 August 2021
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	<StructureSection load='1jkr' size='340' side='right'caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='1jkr' size='340' side='right'caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JKR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [~~http~~://pdbe.org/1jkr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jkr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jkr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [https://pdbe.org/1jkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [https://www.ebi.ac.uk/pdbsum/1jkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jkr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HIN_SALTY HIN_SALTY]] A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.	+	[[https://www.uniprot.org/uniprot/HIN_SALTY HIN_SALTY]] A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Resolvase\|Resolvase]]	+	*[[Resolvase 3D structures\|Resolvase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:08, 6 November 2019

OCA — Wed, 06 Nov 2019 09:08:44 GMT

←Older revision		Revision as of 09:08, 6 November 2019
Line 1:		Line 1:

	==Testing the Water-Mediated HIN Recombinase DNA Recognition by Systematic Mutations==		==Testing the Water-Mediated HIN Recombinase DNA Recognition by Systematic Mutations==
-	<StructureSection load='1jkr' size='340' side='right' caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>	+	<StructureSection load='1jkr' size='340' side='right'caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JKR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JKR FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1jkr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jkr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Resolvase\|Resolvase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chiu, T K]]		[[Category: Chiu, T K]]
	[[Category: Dickerson, R E]]		[[Category: Dickerson, R E]]

OCA at 08:45, 17 January 2018

OCA — Wed, 17 Jan 2018 08:45:50 GMT

←Older revision		Revision as of 08:45, 17 January 2018
Line 1:		Line 1:
		+
	==Testing the Water-Mediated HIN Recombinase DNA Recognition by Systematic Mutations==		==Testing the Water-Mediated HIN Recombinase DNA Recognition by Systematic Mutations==
	<StructureSection load='1jkr' size='340' side='right' caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='1jkr' size='340' side='right' caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [http://pdbe.org/1jkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [http://www.ebi.ac.uk/pdbsum/1jkr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [http://pdbe.org/1jkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [http://www.ebi.ac.uk/pdbsum/1jkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jkr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/1jkr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/1jkr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1jkr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jkr" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Resolvase\|Resolvase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:26, 9 February 2016

OCA — Tue, 09 Feb 2016 23:26:14 GMT

←Older revision		Revision as of 23:26, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jkr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:05, 11 September 2015

OCA — Fri, 11 Sep 2015 03:05:43 GMT

←Older revision		Revision as of 03:05, 11 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [http://www.ebi.ac.uk/pdbsum/1jkr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [http://pdbe.org/1jkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [http://www.ebi.ac.uk/pdbsum/1jkr PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jkr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:34, 16 February 2015

OCA — Mon, 16 Feb 2015 09:34:12 GMT

←Older revision		Revision as of 09:34, 16 February 2015
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Resolvase\|Resolvase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:13, 25 December 2014

OCA — Thu, 25 Dec 2014 10:13:38 GMT

←Older revision		Revision as of 10:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JKR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JKR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [http://www.ebi.ac.uk/pdbsum/1jkr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [http://www.ebi.ac.uk/pdbsum/1jkr PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HIN_SALTY HIN_SALTY]] A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chiu, T K.]]	+	[[Category: Chiu, T K]]
-	[[Category: Dickerson, R E.]]	+	[[Category: Dickerson, R E]]
-	[[Category: Johnson, R C.]]	+	[[Category: Johnson, R C]]
-	[[Category: Sohn, C.]]	+	[[Category: Sohn, C]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]
	[[Category: Hin recombinase]]		[[Category: Hin recombinase]]

OCA at 13:12, 28 September 2014

OCA — Sun, 28 Sep 2014 13:12:24 GMT

←Older revision		Revision as of 13:12, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jkr.~~png~~\|~~left~~\|200px]]	+	==Testing the Water-Mediated HIN Recombinase DNA Recognition by Systematic Mutations==
		+	<StructureSection load='1jkr' size='340' side='right' caption='[[1jkr]], [[Resolution\|resolution]] 2.28Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jkr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JKR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hcr\|1hcr]], [[1ijw\|1ijw]], [[1jj6\|1jj6]], [[1jj8\|1jj8]], [[1jko\|1jko]], [[1jkp\|1jkp]], [[1jkq\|1jkq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jkr RCSB], [http://www.ebi.ac.uk/pdbsum/1jkr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/1jkr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Hin recombinase specifically recognizes its DNA-binding site by means of both major and minor groove interactions. A previous X-ray structure, together with new structures of the Hin DNA-binding domain bound to a recombination half-site that were solved as part of the present study, have revealed that two ordered water molecules are present within the major groove interface. In this report, we test the importance of these waters directly by X-ray crystal structure analysis of complexes with four mutant DNA sequences. These structures, combined with their Hin-binding properties, provide strong support for the critical importance of one of the intermediate waters. A lesser but demonstrable role is ascribed to the second water molecule. The mutant structures also illustrate the prominent roles of thymine methyls both in stabilizing intermediate waters and in interfering with water or amino acid side chain interactions with DNA.

-	~~{{STRUCTURE_1jkr\| PDB=1jkr \| SCENE= }}~~	+	Testing water-mediated DNA recognition by the Hin recombinase.,Chiu TK, Sohn C, Dickerson RE, Johnson RC EMBO J. 2002 Feb 15;21(4):801-14. PMID:11847127<ref>PMID:11847127</ref>

-	~~===Testing~~ the ~~Water-Mediated HIN Recombinase DNA Recognition by Systematic Mutations===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11847127}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jkr]] is a 3 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1JKR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011847127<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Chiu, T K.]]		[[Category: Chiu, T K.]]
	[[Category: Dickerson, R E.]]		[[Category: Dickerson, R E.]]

OCA: Protected "1jkr" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:21:35 GMT

Protected "1jkr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:21, 5 December 2012