1jlj - Revision history

OCA at 08:42, 16 August 2023

OCA — Wed, 16 Aug 2023 08:42:32 GMT

←Older revision		Revision as of 08:42, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1jlj' size='340' side='right'caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1jlj' size='340' side='right'caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [https://pdbe.org/1jlj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [https://www.ebi.ac.uk/pdbsum/1jlj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [~~http~~://pdbe.org/1jlj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jlj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:[~~http~~://omim.org/entry/252150 252150]]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.<ref>PMID:11095995</ref>	+	[https://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN] Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:[https://omim.org/entry/252150 252150]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.<ref>PMID:11095995</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	+	[https://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1jlj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jlj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gephyrin\|Gephyrin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hecht, H J]]	+	[[Category: Hecht H-J]]
-	[[Category: Mendel~~, R R~~]]	+	[[Category: Mendel RR]]
-	[[Category: Schindelin, H]]	+	[[Category: Schindelin H]]
-	[[Category: Schrader, N]]	+	[[Category: Schrader N]]
-	[[Category: Schwarz, G]]	+	[[Category: Schwarz G]]
-	~~[[Category: Globular alpha/beta fold]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 07:33, 25 November 2020

OCA — Wed, 25 Nov 2020 07:33:13 GMT

←Older revision		Revision as of 07:33, 25 November 2020
Line 1:		Line 1:

	==1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin==		==1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin==
-	<StructureSection load='1jlj' size='340' side='right' caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='1jlj' size='340' side='right'caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://pdbe.org/1jlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://pdbe.org/1jlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hecht, H J]]		[[Category: Hecht, H J]]
	[[Category: Mendel, R R]]		[[Category: Mendel, R R]]

OCA at 09:07, 17 January 2018

OCA — Wed, 17 Jan 2018 09:07:02 GMT

←Older revision		Revision as of 09:07, 17 January 2018
Line 1:		Line 1:
		+
	==1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin==		==1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin==
	<StructureSection load='1jlj' size='340' side='right' caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1jlj' size='340' side='right' caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://pdbe.org/1jlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://pdbe.org/1jlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jlj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jlj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:21, 7 February 2016

OCA — Sun, 07 Feb 2016 23:21:36 GMT

←Older revision		Revision as of 23:21, 7 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jlj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:47, 10 September 2015

OCA — Thu, 10 Sep 2015 05:47:34 GMT

←Older revision		Revision as of 05:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1jlj' size='340' side='right' caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1jlj' size='340' side='right' caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://pdbe.org/1jlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jlj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hecht, H J]]		[[Category: Hecht, H J]]
	[[Category: Mendel, R R]]		[[Category: Mendel, R R]]

OCA at 12:09, 2 January 2015

OCA — Fri, 02 Jan 2015 12:09:17 GMT

←Older revision		Revision as of 12:09, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:[http://omim.org/entry/252150 252150]]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.<ref>PMID:11095995</ref>		[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:[http://omim.org/entry/252150 252150]]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.<ref>PMID:11095995</ref>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hecht, H J.]]	+	[[Category: Hecht, H J]]
-	[[Category: Mendel, R R.]]	+	[[Category: Mendel, R R]]
-	[[Category: Schindelin, H.]]	+	[[Category: Schindelin, H]]
-	[[Category: Schrader, N.]]	+	[[Category: Schrader, N]]
-	[[Category: Schwarz, G.]]	+	[[Category: Schwarz, G]]
	[[Category: Globular alpha/beta fold]]		[[Category: Globular alpha/beta fold]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 15:11, 29 September 2014

OCA — Mon, 29 Sep 2014 15:11:04 GMT

←Older revision		Revision as of 15:11, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1jlj\| PDB=1jlj \| SCENE= }}~~	+	==1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin==
-	===1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin===	+	<StructureSection load='1jlj' size='340' side='right' caption='[[1jlj]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_11554796}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLJ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
-	[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:[http://omim.org/entry/252150 252150]]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.<ref>PMID:11095995</ref>	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1di6\|1di6]], [[1di7\|1di7]], [[1ihc\|1ihc]], [[1g8r\|1g8r]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEPHYRIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==Function==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlj RCSB], [http://www.ebi.ac.uk/pdbsum/1jlj PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:[http://omim.org/entry/252150 252150]]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.<ref>PMID:11095995</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.		[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jlj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molybdenum cofactor (Moco) consists of a unique and conserved pterin derivative, usually referred to as molybdopterin (MPT), which coordinates the essential transition metal molybdenum (Mo). Moco is required for the enzymatic activities of all Mo-enzymes, with the exception of nitrogenase and is synthesized by an evolutionary old multi-step pathway that is dependent on the activities of at least six gene products. In eukaryotes, the final step of Moco biosynthesis, i.e. transfer and insertion of Mo into MPT, is catalyzed by the two-domain proteins Cnx1 in plants and gephyrin in mammals. Gephyrin is ubiquitously expressed, and was initially found in the central nervous system, where it is essential for clustering of inhibitory neuroreceptors in the postsynaptic membrane. Gephyrin and Cnx1 contain at least two functional domains (E and G) that are homologous to the Escherichia coli proteins MoeA and MogA, the atomic structures of which have been solved recently. Here, we present the crystal structures of the N-terminal human gephyrin G domain (Geph-G) and the C-terminal Arabidopsis thaliana Cnx1 G domain (Cnx1-G) at 1.7 and 2.6 A resolution, respectively. These structures are highly similar and compared to MogA reveal four major differences in their three-dimensional structures: (1) In Geph-G and Cnx1-G an additional alpha-helix is present between the first beta-strand and alpha-helix of MogA. (2) The loop between alpha 2 and beta 2 undergoes conformational changes in all three structures. (3) A beta-hairpin loop found in MogA is absent from Geph-G and Cnx1-G. (4) The C terminus of Geph-G follows a different path from that in MogA. Based on the structures of the eukaryotic proteins and their comparisons with E. coli MogA, the predicted binding site for MPT has been further refined. In addition, the characterized alternative splice variants of gephyrin are analyzed in the context of the three-dimensional structure of Geph-G.

-	~~==About this Structure==~~	+	Crystal structures of human gephyrin and plant Cnx1 G domains: comparative analysis and functional implications.,Schwarz G, Schrader N, Mendel RR, Hecht HJ, Schindelin H J Mol Biol. 2001 Sep 14;312(2):405-18. PMID:11554796<ref>PMID:11554796</ref>
-	~~[[1jlj]] is a 3 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:011554796</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hecht, H J.]]		[[Category: Hecht, H J.]]

OCA: Protected "1jlj" [edit=sysop:move=sysop]

OCA — Mon, 25 Mar 2013 01:40:05 GMT

Protected "1jlj" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:40, 25 March 2013

OCA at 01:40, 25 March 2013

OCA — Mon, 25 Mar 2013 01:40:03 GMT

←Older revision		Revision as of 01:40, 25 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:1jlj.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jlj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jlj\| PDB=1jlj \| SCENE= }}		{{STRUCTURE_1jlj\| PDB=1jlj \| SCENE= }}
-
	===1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin===		===1.6 Angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin===
		+	{{ABSTRACT_PUBMED_11554796}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:[http://omim.org/entry/252150 252150]]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.<ref>PMID:11095995</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_11554796}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/GEPH_HUMAN GEPH_HUMAN]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 11554796~~ is ~~the PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_11554796}}~~	+

	==About this Structure==		==About this Structure==
-	~~1JLJ~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA].	+	[[1jlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11554796~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011554796</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hecht, H J.]]		[[Category: Hecht, H J.]]
Line 31:		Line 21:
	[[Category: Schwarz, G.]]		[[Category: Schwarz, G.]]
	[[Category: Globular alpha/beta fold]]		[[Category: Globular alpha/beta fold]]
-		+	[[Category: Structural protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 17:09:46 2009''~~	+

OCA at 15:09, 16 February 2009

OCA — Mon, 16 Feb 2009 15:09:47 GMT

←Older revision		Revision as of 15:09, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1JLJ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA].	+	1JLJ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLJ OCA].

	==Reference==		==Reference==
-	Crystal structures of human gephyrin and plant Cnx1 G domains: comparative analysis and functional implications., Schwarz G, Schrader N, Mendel RR, Hecht HJ, Schindelin H, J Mol Biol. 2001 Sep 14;312(2):405-18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11554796 11554796]~~	+	<ref group="xtra">PMID:11554796</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Hecht, H J.]]		[[Category: Hecht, H J.]]
	[[Category: Mendel, R R.]]		[[Category: Mendel, R R.]]
Line 33:		Line 32:
	[[Category: Globular alpha/beta fold]]		[[Category: Globular alpha/beta fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 20~~:25:~~53 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:09:46 2009''