1jlz - Revision history

OCA at 18:43, 29 November 2023

OCA — Wed, 29 Nov 2023 18:43:27 GMT

←Older revision		Revision as of 18:43, 29 November 2023
Line 1:		Line 1:

	==Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei==		==Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei==
-	<StructureSection load='1jlz' size='340' side='right'caption='[[1jlz~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1jlz' size='340' side='right'caption='[[1jlz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_obscurus Tityus obscurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [https://pdbe.org/1jlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [https://www.ebi.ac.uk/pdbsum/1jlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [https://pdbe.org/1jlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [https://www.ebi.ac.uk/pdbsum/1jlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KA131_TITOB KA131_TITOB]] Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes.<ref>PMID:11113450</ref>	+	[https://www.uniprot.org/uniprot/KA131_TITOB KA131_TITOB] Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes.<ref>PMID:11113450</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chang, H K]]	+	[[Category: Tityus obscurus]]
-	[[Category: Chen, C]]	+	[[Category: Chang H-K]]
-	[[Category: Shieh, R C]]	+	[[Category: Chen C]]
-	[[Category: Wang, I]]	+	[[Category: Shieh R-C]]
-	[[Category: Wu, S H]]	+	[[Category: Wang I]]
-	[[Category: Yu, H M]]	+	[[Category: Wu S-H]]
-	~~[[Category: Alpha-ktx]]~~	+	[[Category: Yu H-M]]
-	~~[[Category: K+-channel blocker]]~~	+
-	~~[[Category: Scorpion venom]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 07:20, 14 April 2021

OCA — Wed, 14 Apr 2021 07:20:11 GMT

←Older revision		Revision as of 07:20, 14 April 2021
Line 3:		Line 3:
	<StructureSection load='1jlz' size='340' side='right'caption='[[1jlz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1jlz' size='340' side='right'caption='[[1jlz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [~~http~~://pdbe.org/1jlz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jlz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlz ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [https://pdbe.org/1jlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [https://www.ebi.ac.uk/pdbsum/1jlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KA131_TITOB KA131_TITOB]] Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes.<ref>PMID:11113450</ref>	+	[[https://www.uniprot.org/uniprot/KA131_TITOB KA131_TITOB]] Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes.<ref>PMID:11113450</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Potassium channel toxin\|Potassium channel toxin]]	+	*[[Potassium channel toxin 3D structures\|Potassium channel toxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:10, 10 July 2019

OCA — Wed, 10 Jul 2019 07:10:02 GMT

←Older revision		Revision as of 07:10, 10 July 2019
Line 1:		Line 1:

	==Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei==		==Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei==
-	<StructureSection load='1jlz' size='340' side='right' caption='[[1jlz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1jlz' size='340' side='right'caption='[[1jlz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chang, H K]]		[[Category: Chang, H K]]
	[[Category: Chen, C]]		[[Category: Chen, C]]

OCA at 09:41, 4 October 2017

OCA — Wed, 04 Oct 2017 09:41:43 GMT

←Older revision		Revision as of 09:41, 4 October 2017
Line 1:		Line 1:
		+
	==Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei==		==Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei==
	<StructureSection load='1jlz' size='340' side='right' caption='[[1jlz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1jlz' size='340' side='right' caption='[[1jlz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [http://pdbe.org/1jlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [http://www.ebi.ac.uk/pdbsum/1jlz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [http://pdbe.org/1jlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [http://www.ebi.ac.uk/pdbsum/1jlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:08, 11 September 2015

OCA — Fri, 11 Sep 2015 01:08:13 GMT

←Older revision		Revision as of 01:08, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [http://www.ebi.ac.uk/pdbsum/1jlz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [http://pdbe.org/1jlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [http://www.ebi.ac.uk/pdbsum/1jlz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KA131_TITOB KA131_TITOB]] Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes.<ref>PMID:11113450</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jlz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:46, 17 December 2014

OCA — Wed, 17 Dec 2014 13:46:29 GMT

←Older revision		Revision as of 13:46, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1jlz\| PDB=1jlz \| SCENE= }}~~	+	==Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei==
-	===Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei===	+	<StructureSection load='1jlz' size='340' side='right' caption='[[1jlz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_11790849}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLZ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlz RCSB], [http://www.ebi.ac.uk/pdbsum/1jlz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A new K(+)-channel blocking peptide identified from the scorpion venom of Tityus cambridgei (Tc1) is composed of 23 amino acid residues linked with three disulfide bridges. Tc1 is the shortest known toxin from scorpion venom that recognizes the Shaker B K(+) channels and the voltage-dependent K(+) channels in the brain. Synthetic Tc1 was produced using solid-phase synthesis, and its activity was found to be the same as that of native Tc1. The pairings of three disulfide bridges in the synthetic Tc1 were identified by NMR experiments. The NMR solution structures of Tc1 were determined by simulated annealing and energy-minimization calculations using the X-PLOR program. The results showed that Tc1 contains an alpha-helix and a 3(10)-helix at N-terminal Gly(4)-Lys(10) and a double-stranded beta-sheet at Gly(13)-Ile(16) and Arg(19)-Tyr(23), with a type I' beta-turn at Asn(17)-Gly(18). Superposition of each structure with the best structure yielded an average root mean square deviation of 0.26 +/- 0.05 A for the backbone atoms and of 1.40 +/- 0.23 A for heavy atoms in residues 2 to 23. The three-dimensional structure of Tc1 was compared with two structurally and functionally related scorpion toxins, charybdotoxin (ChTx) and noxiustoxin (NTx). We concluded that the C-terminal structure is the most important region for the blocking activity of voltage-gated (Kv-type) channels for scorpion K(+)-channel blockers. We also found that some of the residues in the larger scorpion K(+)-channel blockers (31 to 40 amino acids) are not involved in K(+)-channel blocking activity.

-	~~==About this Structure==~~	+	Solution structure of a K(+)-channel blocker from the scorpion Tityus cambridgei.,Wang I, Wu SH, Chang HK, Shieh RC, Yu HM, Chen C Protein Sci. 2002 Feb;11(2):390-400. PMID:11790849<ref>PMID:11790849</ref>
-	~~[[1jlz]] is a 1 chain~~ structure~~. Full experimental information is available~~ from ~~[http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1JLZ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Potassium channel toxin\|Potassium channel toxin]]		*[[Potassium channel toxin\|Potassium channel toxin]]
-	[[Category: Chang, H K.]]	+	== References ==
-	[[Category: Chen, C.]]	+	<references/>
-	[[Category: Shieh, R C.]]	+	__TOC__
-	[[Category: Wang, I.]]	+	</StructureSection>
-	[[Category: Wu, S H.]]	+	[[Category: Chang, H K]]
-	[[Category: Yu, H M.]]	+	[[Category: Chen, C]]
		+	[[Category: Shieh, R C]]
		+	[[Category: Wang, I]]
		+	[[Category: Wu, S H]]
		+	[[Category: Yu, H M]]
	[[Category: Alpha-ktx]]		[[Category: Alpha-ktx]]
	[[Category: K+-channel blocker]]		[[Category: K+-channel blocker]]
	[[Category: Scorpion venom]]		[[Category: Scorpion venom]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 11:01, 11 March 2013

OCA — Mon, 11 Mar 2013 11:01:48 GMT

←Older revision		Revision as of 11:01, 11 March 2013
Line 1:		Line 1:
-	[[Image:1jlz.png\|left\|200px]]
-
	{{STRUCTURE_1jlz\| PDB=1jlz \| SCENE= }}		{{STRUCTURE_1jlz\| PDB=1jlz \| SCENE= }}
-
	===Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei===		===Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei===
-
	{{ABSTRACT_PUBMED_11790849}}		{{ABSTRACT_PUBMED_11790849}}

OCA: Protected "1jlz" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:11:03 GMT

Protected "1jlz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:11, 5 December 2012

OCA at 11:11, 5 December 2012

OCA — Wed, 05 Dec 2012 11:11:00 GMT

←Older revision		Revision as of 11:11, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jlz.png\|left\|200px]]		[[Image:1jlz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jlz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jlz\| PDB=1jlz \| SCENE= }}		{{STRUCTURE_1jlz\| PDB=1jlz \| SCENE= }}

	===Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei===		===Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11790849}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11790849 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11790849}}		{{ABSTRACT_PUBMED_11790849}}

	==About this Structure==		==About this Structure==
-	~~1JLZ is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA].	+	[[1jlz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA].

-	==~~Reference~~==	+	==See Also==
-	~~Solution structure of a K(+)-channel blocker from the scorpion Tityus cambridgei., Wang I, Wu SH, Chang HK, Shieh RC, Yu HM, Chen C, Protein Sci. 2002 Feb;11(2):390-400. PMID:~~[~~http://www.ncbi.nlm.nih.gov/pubmed/11790849 11790849]~~	+	*[[Potassium channel toxin\|Potassium channel toxin]]
-	[~~[Category: Single protein~~]]	+
	[[Category: Chang, H K.]]		[[Category: Chang, H K.]]
	[[Category: Chen, C.]]		[[Category: Chen, C.]]
Line 33:		Line 20:
	[[Category: Alpha-ktx]]		[[Category: Alpha-ktx]]
	[[Category: K+-channel blocker]]		[[Category: K+-channel blocker]]
-	[[Category: Nmr structure]]
	[[Category: Scorpion venom]]		[[Category: Scorpion venom]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 1 20:27:10 2008''~~	+

OCA at 17:27, 1 July 2008

OCA — Tue, 01 Jul 2008 17:27:12 GMT

←Older revision		Revision as of 17:27, 1 July 2008
Line 1:		Line 1:
-	[[Image:1jlz.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1jlz.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1jlz\| PDB=1jlz \| SCENE= }}		{{STRUCTURE_1jlz\| PDB=1jlz \| SCENE= }}

-	~~'''~~Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei~~'''~~	+	===Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei===


-	~~==Overview==~~	+	<!--
-	~~A new K(+)~~-channel blocking peptide identified from the scorpion venom of Tityus cambridgei (Tc1) is composed of 23 amino acid residues linked with three disulfide bridges. Tc1 is the shortest known toxin from scorpion venom that recognizes the Shaker B K(+) channels and the voltage-~~dependent K(+) channels in~~ the ~~brain. Synthetic Tc1 was produced using solid-phase synthesis, and its activity was found~~ to be the ~~same~~ as that of native Tc1. The pairings of three disulfide bridges in the synthetic Tc1 were identified by NMR experiments. The NMR solution structures of Tc1 were determined by simulated annealing and energy-minimization calculations using the X-PLOR program. The results showed that Tc1 contains an alpha-helix and a 3(10)-helix at N-terminal Gly(4)-Lys(10) and a double-stranded beta-sheet at Gly(13)-Ile(16) and Arg(19)-Tyr(23), with a type I' beta-turn at Asn(17)-Gly(18). Superposition of each structure with the best structure yielded an average root mean square deviation of 0.26 +/~~- 0.05 A for the backbone atoms and of 1.40 +~~/~~- 0~~.~~23 A for heavy atoms in residues 2 to 23~~. ~~The three-dimensional structure of Tc1 was compared with two structurally and functionally related scorpion toxins~~, ~~charybdotoxin (ChTx) and noxiustoxin (NTx). We concluded that the C-terminal structure~~ is the ~~most important region for the blocking activity of voltage-gated (Kv-type) channels for scorpion K(+)-channel blockers~~. ~~We also found that some of the residues in the larger scorpion K(+)~~-~~channel blockers (31 to 40 amino acids) are not involved in K(+)~~-~~channel blocking activity.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_11790849}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11790849 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11790849}}

	==About this Structure==		==About this Structure==
-	1JLZ is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA].	+	1JLZ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLZ OCA].

	==Reference==		==Reference==
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	[[Category: Nmr structure]]		[[Category: Nmr structure]]
	[[Category: Scorpion venom]]		[[Category: Scorpion venom]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 21~~:23:24 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:27:10 2008''