1jng - Revision history

OCA at 06:42, 11 August 2021

OCA — Wed, 11 Aug 2021 06:42:58 GMT

←Older revision		Revision as of 06:42, 11 August 2021
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	<StructureSection load='1jng' size='340' side='right'caption='[[1jng]]' scene=''>		<StructureSection load='1jng' size='340' side='right'caption='[[1jng]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JNG FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jng FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1jng PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jng ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jng FirstGlance], [https://www.ebi.ac.uk/pdbsum/1jng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jng ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:59, 6 November 2019

OCA — Wed, 06 Nov 2019 08:59:57 GMT

←Older revision		Revision as of 08:59, 6 November 2019
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	==STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)==		==STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)==
-	<StructureSection load='1jng' size='340' side='right' caption='[[1jng]]' scene=''>	+	<StructureSection load='1jng' size='340' side='right'caption='[[1jng]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNG FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNG FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Ball, L]]		[[Category: Ball, L]]
	[[Category: Engert]]		[[Category: Engert]]

OCA at 08:37, 17 January 2018

OCA — Wed, 17 Jan 2018 08:37:24 GMT

←Older revision		Revision as of 08:37, 17 January 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNG FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jng FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jng PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jng FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jng PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jng ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:07, 11 February 2016

OCA — Thu, 11 Feb 2016 09:07:15 GMT

←Older revision		Revision as of 09:07, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)==		==STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)==
	<StructureSection load='1jng' size='340' side='right' caption='[[1jng]]' scene=''>		<StructureSection load='1jng' size='340' side='right' caption='[[1jng]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Ball, L]]		[[Category: Ball, L]]
	[[Category: Engert]]		[[Category: Engert]]

OCA at 16:48, 10 September 2015

OCA — Thu, 10 Sep 2015 16:48:58 GMT

←Older revision		Revision as of 16:48, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jng" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:59, 2 January 2015

OCA — Fri, 02 Jan 2015 11:59:56 GMT

←Older revision		Revision as of 11:59, 2 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNG FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jng FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jng PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jng FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jng PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:08, 28 September 2014

OCA — Sun, 28 Sep 2014 09:08:10 GMT

←Older revision		Revision as of 09:08, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)==
		+	<StructureSection load='1jng' size='340' side='right' caption='[[1jng]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jng FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jng PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Ena-VASP family of proteins act as molecular adaptors linking the cytoskeletal system to signal transduction pathways. Their N-terminal EVH1 domains use groups of exposed aromatic residues to specifically recognize 'FPPPP' motifs found in the mammalian zyxin and vinculin proteins, and ActA protein of the intracellular bacterium Listeria monocytogenes. Here, evidence is provided that the affinities of these EVH1-peptide interactions are strongly dependent on the recognition of residues flanking the core FPPPP motifs. Determination of the VASP EVH1 domain solution structure, together with peptide library screening, measurement of individual K(d)s by fluorescence titration, and NMR chemical shift mapping, revealed a second affinity-determining epitope present in all four ActA EVH1-binding motifs. The epitope was shown to interact with a complementary hydrophobic site on the EVH1 surface and to increase strongly the affinity of ActA for EVH1 domains. We propose that this epitope, which is absent in the sequences of the native EVH1-interaction partners zyxin and vinculin, may provide the pathogen with an advantage when competing for the recruitment of the host VASP and Mena proteins in the infected cell.

-	~~[[Image~~:~~1jng~~.~~png\|left\|200px]]~~	+	Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity.,Ball LJ, Kuhne R, Hoffmann B, Hafner A, Schmieder P, Volkmer-Engert R, Hof M, Wahl M, Schneider-Mergener J, Walter U, Oschkinat H, Jarchau T EMBO J. 2000 Sep 15;19(18):4903-14. PMID:10990454<ref>PMID:10990454</ref>

-	~~{{STRUCTURE_1jng\| PDB=1jng \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_10990454}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:010990454<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ball, L]]		[[Category: Ball, L]]
	[[Category: Engert]]		[[Category: Engert]]

OCA: Protected "1jng" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:24:49 GMT

Protected "1jng" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:24, 21 October 2012

OCA at 09:24, 21 October 2012

OCA — Sun, 21 Oct 2012 09:24:46 GMT

←Older revision		Revision as of 09:24, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1jng.png\|left\|200px]]		[[Image:1jng.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jng", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jng\| PDB=1jng \| SCENE= }}		{{STRUCTURE_1jng\| PDB=1jng \| SCENE= }}

	===STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)===		===STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10990454}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10990454 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10990454}}		{{ABSTRACT_PUBMED_10990454}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10990454~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010990454</ref><references group="xtra"/>
	[[Category: Ball, L]]		[[Category: Ball, L]]
	[[Category: Engert]]		[[Category: Engert]]
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	[[Category: Wahl, M]]		[[Category: Wahl, M]]
	[[Category: Walter, U]]		[[Category: Walter, U]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:16:07 2010''

OCA at 05:16, 8 April 2010

OCA — Thu, 08 Apr 2010 05:16:07 GMT

←Older revision		Revision as of 05:16, 8 April 2010
Line 1:		Line 1:
-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1jng.png\|left\|200px]]

-	~~The entry 1JNG is a Theoretical Model titled 'STRUCTURE OF THE ENA~~-~~VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR~~-~~STIMULATED PHOSPHOPROTEIN~~ (~~VASP~~) ~~in Complex with SFEFPPPPTEDEL peptide~~ (~~Theoretical Model~~)'.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1jng", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1jng\| PDB=1jng \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP) IN COMPLEX WITH SFEFPPPPTEDEL PEPTIDE (THEORETICAL MODEL)===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:50:~~25 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_10990454}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10990454 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10990454}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:10990454</ref><references group="xtra"/>
		+	[[Category: Ball, L]]
		+	[[Category: Engert]]
		+	[[Category: Hafner, A]]
		+	[[Category: Hof, M]]
		+	[[Category: Hoffmann, B]]
		+	[[Category: Jarchau, T]]
		+	[[Category: Kuhne, R]]
		+	[[Category: Oschkinat, H]]
		+	[[Category: Schmieder, P]]
		+	[[Category: Schneider-Mergener, J]]
		+	[[Category: Volkmer-, R]]
		+	[[Category: Wahl, M]]
		+	[[Category: Walter, U]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:16:07 2010''