1jny - Revision history

OCA at 07:40, 7 February 2024

OCA — Wed, 07 Feb 2024 07:40:57 GMT

←Older revision		Revision as of 07:40, 7 February 2024
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	<StructureSection load='1jny' size='340' side='right'caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1jny' size='340' side='right'caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [https://pdbe.org/1jny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [https://www.ebi.ac.uk/pdbsum/1jny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jny ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [https://pdbe.org/1jny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [https://www.ebi.ac.uk/pdbsum/1jny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~EF1A_SULSO EF1A_SULSO]~~] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.	+	[https://www.uniprot.org/uniprot/EF1A_SACS2 EF1A_SACS2] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jny ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jny ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structure of elongation factor 1alpha from the archaeon Sulfolobus solfataricus in complex with GDP (SsEF-1alpha.GDP) at 1.8 A resolution is reported. As already known for the eubacterial elongation factor Tu, the SsEF-1alpha.GDP structure consists of three different structural domains. Surprisingly, the analysis of the GDP-binding site reveals that the nucleotide- protein interactions are not mediated by Mg(2+). Furthermore, the residues that usually co-ordinate Mg(2+) through water molecules in the GTP-binding proteins, though conserved in SsEF-1alpha, are located quite far from the binding site. [(3)H]GDP binding experiments confirm that Mg(2+) has only a marginal effect on the nucleotide exchange reaction of SsEF-1alpha, although essential to GTPase activity elicited by SsEF-1alpha. Finally, structural comparisons of SsEF- 1alpha.GDP with yeast EF-1alpha in complex with the nucleotide exchange factor EF-1beta shows that a dramatic rearrangement of the overall structure of EF-1alpha occurs during the nucleotide exchange.
-
-	The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with GDP reveals novel features in nucleotide binding and exchange.,Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V EMBO J. 2001 Oct 1;20(19):5305-11. PMID:11574461<ref>PMID:11574461</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jny" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]		*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 35091]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bocchini, V]]	+	[[Category: Saccharolobus solfataricus]]
-	[[Category: Masullo, M]]	+	[[Category: Bocchini V]]
-	[[Category: Sica, F]]	+	[[Category: Masullo M]]
-	[[Category: Vitagliano, L]]	+	[[Category: Sica F]]
-	[[Category: Zagari, A]]	+	[[Category: Vitagliano L]]
-	~~[[Category: Alpha/beta structure]]~~	+	[[Category: Zagari A]]
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Protein biosynthesis]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 07:20, 14 April 2021

OCA — Wed, 14 Apr 2021 07:20:34 GMT

←Older revision		Revision as of 07:20, 14 April 2021
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	<StructureSection load='1jny' size='340' side='right'caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1jny' size='340' side='right'caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [~~http~~://pdbe.org/1jny PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jny PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [https://pdbe.org/1jny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [https://www.ebi.ac.uk/pdbsum/1jny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/EF1A_SULSO EF1A_SULSO]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.	+	[[https://www.uniprot.org/uniprot/EF1A_SULSO EF1A_SULSO]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:14, 10 July 2019

OCA — Wed, 10 Jul 2019 07:14:41 GMT

←Older revision		Revision as of 07:14, 10 July 2019
Line 1:		Line 1:

	==Crystal structure of Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP==		==Crystal structure of Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP==
-	<StructureSection load='1jny' size='340' side='right' caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1jny' size='340' side='right'caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jny_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jny_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Elongation factor\|Elongation factor]]	+	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 35091]]		[[Category: Atcc 35091]]
		+	[[Category: Large Structures]]
	[[Category: Bocchini, V]]		[[Category: Bocchini, V]]
	[[Category: Masullo, M]]		[[Category: Masullo, M]]

OCA at 09:45, 4 October 2017

OCA — Wed, 04 Oct 2017 09:45:27 GMT

←Older revision		Revision as of 09:45, 4 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP==		==Crystal structure of Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP==
	<StructureSection load='1jny' size='340' side='right' caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1jny' size='340' side='right' caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [http://pdbe.org/1jny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [http://www.ebi.ac.uk/pdbsum/1jny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [http://pdbe.org/1jny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [http://www.ebi.ac.uk/pdbsum/1jny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jny ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sulfolobus solfataricus~~]]	+	[[Category: Atcc 35091]]
	[[Category: Bocchini, V]]		[[Category: Bocchini, V]]
	[[Category: Masullo, M]]		[[Category: Masullo, M]]

OCA at 01:44, 12 September 2015

OCA — Sat, 12 Sep 2015 01:44:15 GMT

←Older revision		Revision as of 01:44, 12 September 2015
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	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [http://www.ebi.ac.uk/pdbsum/1jny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [http://pdbe.org/1jny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [http://www.ebi.ac.uk/pdbsum/1jny PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jny" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:11, 25 December 2014

OCA — Thu, 25 Dec 2014 22:11:02 GMT

←Older revision		Revision as of 22:11, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [http://www.ebi.ac.uk/pdbsum/1jny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [http://www.ebi.ac.uk/pdbsum/1jny PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EF1A_SULSO EF1A_SULSO]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
-	[[Category: Bocchini, V.]]	+	[[Category: Bocchini, V]]
-	[[Category: Masullo, M.]]	+	[[Category: Masullo, M]]
-	[[Category: Sica, F.]]	+	[[Category: Sica, F]]
-	[[Category: Vitagliano, L.]]	+	[[Category: Vitagliano, L]]
-	[[Category: Zagari, A.]]	+	[[Category: Zagari, A]]
	[[Category: Alpha/beta structure]]		[[Category: Alpha/beta structure]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Protein biosynthesis]]		[[Category: Protein biosynthesis]]
	[[Category: Translation]]		[[Category: Translation]]

OCA at 13:33, 28 September 2014

OCA — Sun, 28 Sep 2014 13:33:01 GMT

←Older revision		Revision as of 13:33, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1jny.~~png\|left~~\|200px]]	+	==Crystal structure of Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP==
		+	<StructureSection load='1jny' size='340' side='right' caption='[[1jny]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JNY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jny RCSB], [http://www.ebi.ac.uk/pdbsum/1jny PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jny_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of elongation factor 1alpha from the archaeon Sulfolobus solfataricus in complex with GDP (SsEF-1alpha.GDP) at 1.8 A resolution is reported. As already known for the eubacterial elongation factor Tu, the SsEF-1alpha.GDP structure consists of three different structural domains. Surprisingly, the analysis of the GDP-binding site reveals that the nucleotide- protein interactions are not mediated by Mg(2+). Furthermore, the residues that usually co-ordinate Mg(2+) through water molecules in the GTP-binding proteins, though conserved in SsEF-1alpha, are located quite far from the binding site. [(3)H]GDP binding experiments confirm that Mg(2+) has only a marginal effect on the nucleotide exchange reaction of SsEF-1alpha, although essential to GTPase activity elicited by SsEF-1alpha. Finally, structural comparisons of SsEF- 1alpha.GDP with yeast EF-1alpha in complex with the nucleotide exchange factor EF-1beta shows that a dramatic rearrangement of the overall structure of EF-1alpha occurs during the nucleotide exchange.

-	~~{{STRUCTURE_1jny\| PDB=1jny \| SCENE= }}~~	+	The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with GDP reveals novel features in nucleotide binding and exchange.,Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V EMBO J. 2001 Oct 1;20(19):5305-11. PMID:11574461<ref>PMID:11574461</ref>

-	~~===Crystal structure~~ of ~~Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11574461}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jny]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA].~~	+

	==See Also==		==See Also==
	*[[Elongation factor\|Elongation factor]]		*[[Elongation factor\|Elongation factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011574461<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Bocchini, V.]]		[[Category: Bocchini, V.]]

OCA: Protected "1jny" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 22:14:27 GMT

Protected "1jny" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:14, 20 October 2012

OCA at 22:14, 20 October 2012

OCA — Sat, 20 Oct 2012 22:14:25 GMT

←Older revision		Revision as of 22:14, 20 October 2012
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-	{{Seed}}
	[[Image:1jny.png\|left\|200px]]		[[Image:1jny.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jny", creates the "Structure Box" on the page.
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	{{STRUCTURE_1jny\| PDB=1jny \| SCENE= }}		{{STRUCTURE_1jny\| PDB=1jny \| SCENE= }}

	===Crystal structure of Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP===		===Crystal structure of Sulfolobus solfataricus elongation factor 1 alpha in complex with GDP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11574461}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11574461 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11574461}}		{{ABSTRACT_PUBMED_11574461}}

	==About this Structure==		==About this Structure==
-	~~1JNY~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA].	+	[[1jny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA].
		+
		+	==See Also==
		+	*[[Elongation factor\|Elongation factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11574461~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011574461</ref><references group="xtra"/>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Bocchini, V.]]		[[Category: Bocchini, V.]]
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	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Protein biosynthesis]]		[[Category: Protein biosynthesis]]
-		+	[[Category: Translation]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:24:35 2009''~~	+

OCA at 07:24, 18 February 2009

OCA — Wed, 18 Feb 2009 07:24:36 GMT

←Older revision		Revision as of 07:24, 18 February 2009
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	==About this Structure==		==About this Structure==
-	1JNY is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA].	+	1JNY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNY OCA].

	==Reference==		==Reference==
-	The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with GDP reveals novel features in nucleotide binding and exchange., Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V, EMBO J. 2001 Oct 1;20(19):5305-11. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11574461 11574461]~~	+	<ref group="xtra">PMID:11574461</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Bocchini, V.]]		[[Category: Bocchini, V.]]
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	[[Category: Protein biosynthesis]]		[[Category: Protein biosynthesis]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 20~~:32:~~03 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:24:35 2009''