1job - Revision history

OCA at 08:43, 16 August 2023

OCA — Wed, 16 Aug 2023 08:43:35 GMT

←Older revision		Revision as of 08:43, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1job' size='340' side='right'caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1job' size='340' side='right'caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1JOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JOB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1f35\|1f35]], [[1jod\|1jod]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [https://pdbe.org/1job PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [https://www.ebi.ac.uk/pdbsum/1job PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1job ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [~~http~~://pdbe.org/1job PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1job PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1job ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OMP_MOUSE OMP_MOUSE]] May act as a modulator of the olfactory signal-transduction cascade.	+	[https://www.uniprot.org/uniprot/OMP_MOUSE OMP_MOUSE] May act as a modulator of the olfactory signal-transduction cascade.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hunt~~, J F~~]]	+	[[Category: Hunt JF]]
-	[[Category: Smith, P]]	+	[[Category: Smith P]]
-	~~[[Category: Beta clamshell]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:34, 25 November 2020

OCA — Wed, 25 Nov 2020 07:34:02 GMT

←Older revision		Revision as of 07:34, 25 November 2020
Line 1:		Line 1:

	==Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121==		==Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121==
-	<StructureSection load='1job' size='340' side='right' caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1job' size='340' side='right'caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JOB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f35\|1f35]], [[1jod\|1jod]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://pdbe.org/1job PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1job ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://pdbe.org/1job PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1job ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/1job_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/1job_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hunt, J F]]		[[Category: Hunt, J F]]

OCA at 09:46, 12 October 2017

OCA — Thu, 12 Oct 2017 09:46:11 GMT

←Older revision		Revision as of 09:46, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121==		==Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121==
	<StructureSection load='1job' size='340' side='right' caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1job' size='340' side='right' caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://pdbe.org/1job PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://pdbe.org/1job PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1job ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:42, 7 February 2016

OCA — Sun, 07 Feb 2016 19:42:36 GMT

←Older revision		Revision as of 19:42, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1job ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:26, 10 September 2015

OCA — Thu, 10 Sep 2015 04:26:34 GMT

←Older revision		Revision as of 04:26, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1job' size='340' side='right' caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1job' size='340' side='right' caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JOB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://pdbe.org/1job PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1job" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hunt, J F]]		[[Category: Hunt, J F]]
	[[Category: Smith, P]]		[[Category: Smith, P]]
	[[Category: Beta clamshell]]		[[Category: Beta clamshell]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 17:47, 24 December 2014

OCA — Wed, 24 Dec 2014 17:47:39 GMT

←Older revision		Revision as of 17:47, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JOB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JOB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OMP_MOUSE OMP_MOUSE]] May act as a modulator of the olfactory signal-transduction cascade.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Hunt, J F.]]	+	[[Category: Hunt, J F]]
-	[[Category: Smith, P.]]	+	[[Category: Smith, P]]
	[[Category: Beta clamshell]]		[[Category: Beta clamshell]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA: Protected "1job" [edit=sysop:move=sysop]

OCA — Sun, 28 Sep 2014 08:59:44 GMT

Protected "1job" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:59, 28 September 2014

OCA at 08:59, 28 September 2014

OCA — Sun, 28 Sep 2014 08:59:42 GMT

←Older revision		Revision as of 08:59, 28 September 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121==
-	[[~~Image:~~1job.~~png~~\|~~left~~\|200px]]	+	<StructureSection load='1job' size='340' side='right' caption='[[1job]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1job]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JOB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f35\|1f35]], [[1jod\|1jod]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OMP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1job FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1job OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1job RCSB], [http://www.ebi.ac.uk/pdbsum/1job PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/1job_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Olfactory marker protein (OMP) is a highly expressed and phylogenetically conserved cytoplasmic protein of unknown function found almost exclusively in mature olfactory sensory neurons. Electrophysiological studies of olfactory epithelia in OMP knock-out mice show strongly retarded recovery following odorant stimulation leading to an impaired response to pulsed odor stimulation. Although these studies show that OMP is a modulator of the olfactory signal-transduction cascade, its biochemical role is not established. In order to facilitate further studies on the molecular function of OMP, its crystal structure has been determined at 2.3 A resolution using multiwavelength anomalous diffraction experiments on selenium-labeled protein. OMP is observed to form a modified beta-clamshell structure with eight antiparallel beta-strands. While OMP has no significant sequence homology to proteins of known structure, it has a similar fold to a domain found in a variety of existing structures, including in a large family of viral capsid proteins. The surface of OMP is mostly convex and lacking obvious small molecule binding sites, suggesting that it is more likely to be involved in modulating protein-protein interaction than in interacting with small molecule ligands. Three highly conserved regions have been identified as leading candidates for protein-protein interaction sites in OMP. One of these sites represents a loop known to mediate ligand interactions in the structurally homologous EphB2 receptor ligand-binding domain. This site is partially buried in the crystal structure but fully exposed in the NMR solution structure of OMP due to a change in the orientation of an alpha-helix that projects outward from the structurally invariant beta-clamshell core. Gating of this conformational change by molecular interactions in the signal-transduction cascade could be used to control access to OMP's equivalent of the EphB2 ligand-interaction loop, thereby allowing OMP to function as a molecular switch.

-	~~<!--~~	+	The crystal structure of the olfactory marker protein at 2.3 A resolution.,Smith PC, Firestein S, Hunt JF J Mol Biol. 2002 Jun 7;319(3):807-21. PMID:12054872<ref>PMID:12054872</ref>
-	The ~~line below this paragraph~~, ~~containing "STRUCTURE_1job"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_1job\| PDB=1job \| SCENE= }}~~	+

-	~~===Crystal Structure~~ of ~~Murine Olfactory Marker Protein in Spacegroup P3121===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_12054872}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 12054872 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_12054872}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~1JOB is a 1 chain structure of sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:12054872<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hunt, J F.]]		[[Category: Hunt, J F.]]
	[[Category: Smith, P.]]		[[Category: Smith, P.]]
	[[Category: Beta clamshell]]		[[Category: Beta clamshell]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 16:04:53 2009''~~	+

OCA at 14:04, 16 February 2009

OCA — Mon, 16 Feb 2009 14:04:55 GMT

←Older revision		Revision as of 14:04, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1JOB is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA].	+	1JOB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOB OCA].

	==Reference==		==Reference==
-	~~The crystal structure of the olfactory marker protein at 2.3 A resolution., Smith PC, Firestein S, Hunt JF, J Mol Biol. 2002 Jun 7;319(3):807-21.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12054872 12054872]~~	+	<ref group="xtra">PMID:12054872</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Hunt, J F.]]		[[Category: Hunt, J F.]]
	[[Category: Smith, P.]]		[[Category: Smith, P.]]
	[[Category: Beta clamshell]]		[[Category: Beta clamshell]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 20~~:32:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:04:53 2009''

OCA at 17:32, 1 July 2008

OCA — Tue, 01 Jul 2008 17:32:56 GMT

←Older revision		Revision as of 17:32, 1 July 2008
Line 1:		Line 1:
-	[[Image:1job.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1job.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1job\| PDB=1job \| SCENE= }}		{{STRUCTURE_1job\| PDB=1job \| SCENE= }}

-	~~'''~~Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121~~'''~~	+	===Crystal Structure of Murine Olfactory Marker Protein in Spacegroup P3121===


-	~~==Overview==~~	+	<!--
-	Olfactory marker protein (OMP) is a highly expressed and phylogenetically conserved cytoplasmic protein of unknown function found almost exclusively in mature olfactory sensory neurons. Electrophysiological studies of olfactory epithelia in OMP knock-out mice show strongly retarded recovery following odorant stimulation leading to an impaired response to pulsed odor stimulation. Although these studies show that OMP is a modulator of the olfactory signal-~~transduction cascade~~, ~~its biochemical role is not established. In order~~ to ~~facilitate further studies~~ on ~~the molecular function of OMP, its crystal structure has been determined~~ at 2.~~3 A resolution using multiwavelength anomalous diffraction experiments on selenium-labeled protein~~. ~~OMP is observed to form a modified beta-clamshell structure with eight antiparallel beta-strands. While OMP has no significant sequence homology to proteins of known structure~~, ~~it has a similar fold to a domain found in a variety of existing structures, including in a large family of viral capsid proteins. The surface of OMP~~ is mostly convex and lacking obvious small molecule binding sites, suggesting that it is more likely to be involved in modulating protein-protein interaction than in interacting with small molecule ligands. Three highly conserved regions have been identified as leading candidates for protein-protein interaction sites in OMP. One of these sites represents a loop known to mediate ligand interactions in the ~~structurally homologous EphB2 receptor ligand-binding domain~~. ~~This site is partially buried in the crystal structure but fully exposed in the NMR solution structure of OMP due to a change in the orientation of an alpha~~-~~helix that projects outward from the structurally invariant beta~~-clamshell core. Gating of this conformational change by molecular interactions in the signal-transduction cascade could be used to control access to OMP's equivalent of the EphB2 ligand-interaction loop, thereby allowing OMP to function as a molecular switch.	+	The line below this paragraph, {{ABSTRACT_PUBMED_12054872}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12054872 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12054872}}

	==About this Structure==		==About this Structure==
Line 25:		Line 29:
	[[Category: Smith, P.]]		[[Category: Smith, P.]]
	[[Category: Beta clamshell]]		[[Category: Beta clamshell]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 21~~:29:56 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:32:55 2008''