1jpj - Revision history

OCA at 08:44, 16 August 2023

OCA — Wed, 16 Aug 2023 08:44:01 GMT

←Older revision		Revision as of 08:44, 16 August 2023
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	<StructureSection load='1jpj' size='340' side='right'caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1jpj' size='340' side='right'caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_25104 Atcc 25104~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~GUANYLATE+ESTER'>GNP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1jpn\|1jpn]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [https://pdbe.org/1jpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [https://www.ebi.ac.uk/pdbsum/1jpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [https://pdbe.org/1jpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [https://www.ebi.ac.uk/pdbsum/1jpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306]	+	[https://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 25104]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Freymann, D M~~]]	+	[[Category: Thermus aquaticus]]
-	[[Category: ~~Padmanabhan, S~~]]	+	[[Category: Freymann DM]]
-	[[Category: ~~Ffh]]~~	+	[[Category: Padmanabhan S]]
-	~~[[Category: Gmppnp]]~~	+
-	~~[[Category: Ng domain]]~~	+
-	~~[[Category: Signal recognition particle]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Srp]]~~	+
-	~~[[Category: Srp54~~]]	+

OCA at 07:21, 14 April 2021

OCA — Wed, 14 Apr 2021 07:21:06 GMT

←Older revision		Revision as of 07:21, 14 April 2021
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	<StructureSection load='1jpj' size='340' side='right'caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1jpj' size='340' side='right'caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jpn\|1jpn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [~~http~~://pdbe.org/1jpj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jpj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [https://pdbe.org/1jpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [https://www.ebi.ac.uk/pdbsum/1jpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306]	+	[[https://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:50, 10 July 2019

OCA — Wed, 10 Jul 2019 06:50:06 GMT

←Older revision		Revision as of 06:50, 10 July 2019
Line 1:		Line 1:

	==GMPPNP Complex of SRP GTPase NG Domain==		==GMPPNP Complex of SRP GTPase NG Domain==
-	<StructureSection load='1jpj' size='340' side='right' caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1jpj' size='340' side='right'caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jpj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jpj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 25104]]		[[Category: Atcc 25104]]
		+	[[Category: Large Structures]]
	[[Category: Freymann, D M]]		[[Category: Freymann, D M]]
	[[Category: Padmanabhan, S]]		[[Category: Padmanabhan, S]]

OCA at 09:40, 4 October 2017

OCA — Wed, 04 Oct 2017 09:40:48 GMT

←Older revision		Revision as of 09:40, 4 October 2017
Line 1:		Line 1:
		+
	==GMPPNP Complex of SRP GTPase NG Domain==		==GMPPNP Complex of SRP GTPase NG Domain==
	<StructureSection load='1jpj' size='340' side='right' caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1jpj' size='340' side='right' caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [http://pdbe.org/1jpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [http://www.ebi.ac.uk/pdbsum/1jpj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [http://pdbe.org/1jpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [http://www.ebi.ac.uk/pdbsum/1jpj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jpj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:28, 11 September 2015

OCA — Fri, 11 Sep 2015 13:28:02 GMT

←Older revision		Revision as of 13:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jpj' size='340' side='right' caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1jpj' size='340' side='right' caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_aquaticus Thermus aquaticus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [http://www.ebi.ac.uk/pdbsum/1jpj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [http://pdbe.org/1jpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [http://www.ebi.ac.uk/pdbsum/1jpj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jpj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus aquaticus~~]]	+	[[Category: Atcc 25104]]
	[[Category: Freymann, D M]]		[[Category: Freymann, D M]]
	[[Category: Padmanabhan, S]]		[[Category: Padmanabhan, S]]

OCA at 17:04, 25 December 2014

OCA — Thu, 25 Dec 2014 17:04:34 GMT

←Older revision		Revision as of 17:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [http://www.ebi.ac.uk/pdbsum/1jpj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [http://www.ebi.ac.uk/pdbsum/1jpj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
-	[[Category: Freymann, D M.]]	+	[[Category: Freymann, D M]]
-	[[Category: Padmanabhan, S.]]	+	[[Category: Padmanabhan, S]]
	[[Category: Ffh]]		[[Category: Ffh]]
	[[Category: Gmppnp]]		[[Category: Gmppnp]]

OCA at 11:36, 28 September 2014

OCA — Sun, 28 Sep 2014 11:36:28 GMT

←Older revision		Revision as of 11:36, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jpj.~~png~~\|~~left~~\|200px]]	+	==GMPPNP Complex of SRP GTPase NG Domain==
		+	<StructureSection load='1jpj' size='340' side='right' caption='[[1jpj]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpn\|1jpn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jpj RCSB], [http://www.ebi.ac.uk/pdbsum/1jpj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jpj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: The signal recognition particle (SRP) is a phylogenetically conserved ribonucleoprotein that mediates cotranslational targeting of secreted and membrane proteins to the membrane. Targeting is regulated by GTP binding and hydrolysis events that require direct interaction between structurally homologous "NG" GTPase domains of the SRP signal recognition subunit and its membrane-associated receptor, SR alpha. Structures of both the apo and GDP bound NG domains of the prokaryotic SRP54 homolog, Ffh, and the prokaryotic receptor homolog, FtsY, have been determined. The structural basis for the GTP-dependent interaction between the two proteins, however, remains unknown. RESULTS: We report here two structures of the NG GTPase of Ffh from Thermus aquaticus bound to the nonhydrolyzable GTP analog GMPPNP. Both structures reveal an unexpected binding mode in which the beta-phosphate is kinked away from the binding site and magnesium is not bound. Binding of the GTP analog in the canonical conformation found in other GTPase structures is precluded by constriction of the phosphate binding P loop. The structural difference between the Ffh complex and other GTPases suggests a specific conformational change that must accompany movement of the nucleotide from an "inactive" to an "active" binding mode. CONCLUSIONS: Conserved side chains of the GTPase sequence motifs unique to the SRP subfamily may function to gate formation of the active GTP bound conformation. Exposed hydrophobic residues provide an interaction surface that may allow regulation of the GTP binding conformation, and thus activation of the GTPase, during the association of SRP with its receptor.

-	~~{{STRUCTURE_1jpj\| PDB=1jpj \| SCENE= }}~~	+	The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase.,Padmanabhan S, Freymann DM Structure. 2001 Sep;9(9):859-67. PMID:11566135<ref>PMID:11566135</ref>

-	~~===GMPPNP Complex~~ of ~~SRP GTPase NG Domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11566135}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jpj]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_aquaticus Thermus aquaticus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA].~~	+

	==See Also==		==See Also==
	*[[Signal recognition particle protein\|Signal recognition particle protein]]		*[[Signal recognition particle protein\|Signal recognition particle protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011566135<~~/~~ref~~><~~ref group="xtra">PMID:014985753</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
	[[Category: Freymann, D M.]]		[[Category: Freymann, D M.]]

OCA at 19:14, 20 October 2012

OCA — Sat, 20 Oct 2012 19:14:12 GMT

←Older revision		Revision as of 19:14, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1jpj]] is a 1 chain structure ~~of [[Signal recognition particle protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA].	+	[[1jpj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA].

	==See Also==		==See Also==

OCA: Protected "1jpj" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 06:42:22 GMT

Protected "1jpj" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 27 July 2012

OCA at 06:42, 27 July 2012

OCA — Fri, 27 Jul 2012 06:42:21 GMT

←Older revision		Revision as of 06:42, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jpj.png\|left\|200px]]		[[Image:1jpj.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1jpj\| PDB=1jpj \| SCENE= }}		{{STRUCTURE_1jpj\| PDB=1jpj \| SCENE= }}

	===GMPPNP Complex of SRP GTPase NG Domain===		===GMPPNP Complex of SRP GTPase NG Domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11566135}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11566135 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11566135}}		{{ABSTRACT_PUBMED_11566135}}

	==About this Structure==		==About this Structure==
-	~~1JPJ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA].	+	[[1jpj]] is a 1 chain structure of [[Signal recognition particle protein]] with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPJ OCA].
		+
		+	==See Also==
		+	*[[Signal recognition particle protein\|Signal recognition particle protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11566135~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011566135</ref><ref group="xtra">PMID:014985753</ref><references group="xtra"/>
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
	[[Category: Freymann, D M.]]		[[Category: Freymann, D M.]]
Line 31:		Line 22:
	[[Category: Ng domain]]		[[Category: Ng domain]]
	[[Category: Signal recognition particle]]		[[Category: Signal recognition particle]]
		+	[[Category: Signaling protein]]
	[[Category: Srp]]		[[Category: Srp]]
	[[Category: Srp54]]		[[Category: Srp54]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:07:16 2009''