1jps - Revision history

OCA at 07:15, 25 October 2023

OCA — Wed, 25 Oct 2023 07:15:30 GMT

←Older revision		Revision as of 07:15, 25 October 2023
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	<StructureSection load='1jps' size='340' side='right'caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1jps' size='340' side='right'caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPS FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1jpt\|1jpt]]~~, [[~~2hft~~\|~~2hft~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [https://pdbe.org/1jps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [https://www.ebi.ac.uk/pdbsum/1jps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [https://pdbe.org/1jps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [https://www.ebi.ac.uk/pdbsum/1jps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>	+	[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Faelber, K]]	+	[[Category: Faelber K]]
-	[[Category: Kelley~~, R F~~]]	+	[[Category: Kelley RF]]
-	[[Category: Kirchhofer, D]]	+	[[Category: Kirchhofer D]]
-	[[Category: Muller~~, Y A~~]]	+	[[Category: Muller YA]]
-	[[Category: Presta, L]]	+	[[Category: Presta L]]
-	~~[[Category: Antigen-antibody recognition]]~~	+
-	~~[[Category: Blood coagulation]]~~	+
-	~~[[Category: Humanized antibody]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Interface water molecule~~]]	+

OCA at 07:21, 14 April 2021

OCA — Wed, 14 Apr 2021 07:21:10 GMT

←Older revision		Revision as of 07:21, 14 April 2021
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	<StructureSection load='1jps' size='340' side='right'caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1jps' size='340' side='right'caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JPS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPS FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jpt\|1jpt]], [[2hft\|2hft]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [~~http~~://pdbe.org/1jps PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jps PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jps ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [https://pdbe.org/1jps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [https://www.ebi.ac.uk/pdbsum/1jps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>	+	[[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Tissue factor\|Tissue factor]]		*[[Tissue factor\|Tissue factor]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:55, 10 July 2019

OCA — Wed, 10 Jul 2019 06:55:54 GMT

←Older revision		Revision as of 06:55, 10 July 2019
Line 1:		Line 1:

	==Crystal structure of tissue factor in complex with humanized Fab D3h44==		==Crystal structure of tissue factor in complex with humanized Fab D3h44==
-	<StructureSection load='1jps' size='340' side='right' caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='1jps' size='340' side='right'caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jps_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jps_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:

	==See Also==		==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Tissue factor\|Tissue factor]]		*[[Tissue factor\|Tissue factor]]
-	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Faelber, K]]		[[Category: Faelber, K]]
	[[Category: Kelley, R F]]		[[Category: Kelley, R F]]

OCA at 09:47, 4 October 2017

OCA — Wed, 04 Oct 2017 09:47:08 GMT

←Older revision		Revision as of 09:47, 4 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of tissue factor in complex with humanized Fab D3h44==		==Crystal structure of tissue factor in complex with humanized Fab D3h44==
	<StructureSection load='1jps' size='340' side='right' caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1jps' size='340' side='right' caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [http://pdbe.org/1jps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [http://www.ebi.ac.uk/pdbsum/1jps PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [http://pdbe.org/1jps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [http://www.ebi.ac.uk/pdbsum/1jps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jps ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]
	*[[Tissue factor\|Tissue factor]]		*[[Tissue factor\|Tissue factor]]
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:28, 12 September 2015

OCA — Sat, 12 Sep 2015 00:28:17 GMT

←Older revision		Revision as of 00:28, 12 September 2015
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	<StructureSection load='1jps' size='340' side='right' caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1jps' size='340' side='right' caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [http://www.ebi.ac.uk/pdbsum/1jps PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [http://pdbe.org/1jps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [http://www.ebi.ac.uk/pdbsum/1jps PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jps" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Faelber, K]]		[[Category: Faelber, K]]
	[[Category: Kelley, R F]]		[[Category: Kelley, R F]]

OCA at 21:26, 25 December 2014

OCA — Thu, 25 Dec 2014 21:26:08 GMT

←Older revision		Revision as of 21:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [http://www.ebi.ac.uk/pdbsum/1jps PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [http://www.ebi.ac.uk/pdbsum/1jps PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Faelber, K.]]	+	[[Category: Faelber, K]]
-	[[Category: Kelley, R F.]]	+	[[Category: Kelley, R F]]
-	[[Category: Kirchhofer, D.]]	+	[[Category: Kirchhofer, D]]
-	[[Category: Muller, Y A.]]	+	[[Category: Muller, Y A]]
-	[[Category: Presta, L.]]	+	[[Category: Presta, L]]
	[[Category: Antigen-antibody recognition]]		[[Category: Antigen-antibody recognition]]
	[[Category: Blood coagulation]]		[[Category: Blood coagulation]]

OCA at 12:29, 28 September 2014

OCA — Sun, 28 Sep 2014 12:29:02 GMT

←Older revision		Revision as of 12:29, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jps.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of tissue factor in complex with humanized Fab D3h44==
		+	<StructureSection load='1jps' size='340' side='right' caption='[[1jps]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jpt\|1jpt]], [[2hft\|2hft]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jps RCSB], [http://www.ebi.ac.uk/pdbsum/1jps PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jps_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The outstanding importance of the antigen-antibody recognition process for the survival and defence strategy of higher organisms is in sharp contrast to the limited high resolution structural data available on antibody-antigen pairs with antigenic proteins. The limitation is the most severe for structural data not restricted to the antigen-antibody complex but extending to the uncomplexed antigen and antibody. We report the crystal structure of the complex between tissue factor (TF) and the humanized Fab fragment D3h44 at a resolution of 1.85 A together with the structure of uncomplexed D3h44 at the same resolution. In conjunction with the previously reported 1.7 A crystal structure of uncomplexed TF, a unique opportunity is generated to explore details of the recognition process. The TF.D3h44 interface is characterised by a high number of polar interactions, including as may as 46 solvent molecules. Conformational changes upon complex formation are very small and almost exclusively limited to the reorientation of side-chains. The binding epitope is in complete agreement with earlier mutagenesis experiments. A revaluation of two other antibody-antigen pairs reported at similar resolutions, shows that all these complexes are very similar with respect to the solvation of the interface, the number of solvent positions conserved in the uncomplexed and complexed proteins and the number of water molecules expelled from the surface and replaced by hydrophilic atoms from the binding partner upon complex formation. A strategy is proposed on how to exploit this high resolution structural data to guide the affinity maturation of humanised antibodies.

-	~~{{STRUCTURE_1jps\| PDB=1jps \| SCENE= }}~~	+	The 1.85 A resolution crystal structures of tissue factor in complex with humanized Fab D3h44 and of free humanized Fab D3h44: revisiting the solvation of antigen combining sites.,Faelber K, Kirchhofer D, Presta L, Kelley RF, Muller YA J Mol Biol. 2001 Oct 12;313(1):83-97. PMID:11601848<ref>PMID:11601848</ref>

-	~~===Crystal structure~~ of ~~tissue factor in complex with humanized Fab D3h44===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11601848}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jps]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	*[[Tissue factor\|Tissue factor]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:011601848<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Faelber, K.]]		[[Category: Faelber, K.]]

OCA at 21:50, 20 October 2012

OCA — Sat, 20 Oct 2012 21:50:43 GMT

←Older revision		Revision as of 21:50, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1jps]] is a 3 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA].	+	[[1jps]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA].

	==See Also==		==See Also==

OCA: Protected "1jps" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 14:27:48 GMT

Protected "1jps" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:27, 27 July 2012

OCA at 14:27, 27 July 2012

OCA — Fri, 27 Jul 2012 14:27:47 GMT

←Older revision		Revision as of 14:27, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jps.png\|left\|200px]]		[[Image:1jps.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jps", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jps\| PDB=1jps \| SCENE= }}		{{STRUCTURE_1jps\| PDB=1jps \| SCENE= }}

	===Crystal structure of tissue factor in complex with humanized Fab D3h44===		===Crystal structure of tissue factor in complex with humanized Fab D3h44===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11601848}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11601848 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11601848}}		{{ABSTRACT_PUBMED_11601848}}

	==About this Structure==		==About this Structure==
-	~~1JPS~~ is a 3 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA].	+	[[1jps]] is a 3 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPS OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11601848~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011601848</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Faelber, K.]]		[[Category: Faelber, K.]]
Line 32:		Line 23:
	[[Category: Antigen-antibody recognition]]		[[Category: Antigen-antibody recognition]]
	[[Category: Blood coagulation]]		[[Category: Blood coagulation]]
-	[[Category: Crystal structure]]
	[[Category: Humanized antibody]]		[[Category: Humanized antibody]]
		+	[[Category: Immune system]]
	[[Category: Interface water molecule]]		[[Category: Interface water molecule]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:04:16 2009''