1jqp - Revision history

OCA at 07:53, 3 April 2024

OCA — Wed, 03 Apr 2024 07:53:54 GMT

←Older revision		Revision as of 07:53, 3 April 2024
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	<StructureSection load='1jqp' size='340' side='right'caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1jqp' size='340' side='right'caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [https://pdbe.org/1jqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [https://www.ebi.ac.uk/pdbsum/1jqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [https://pdbe.org/1jqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [https://www.ebi.ac.uk/pdbsum/1jqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CATC_RAT CATC_RAT]] Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).	+	[https://www.uniprot.org/uniprot/CATC_RAT CATC_RAT] Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqp ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structure of mature dipeptidyl peptidase I reveals insight into the unique tetrameric structure, substrate binding and activation of this atypical papain family peptidase. Each subunit is composed of three peptides. The heavy and light chains form the catalytic domain, which adopts the papain fold. The residual pro-part forms a beta-barrel with the carboxylate group of Asp1 pointing towards the substrate amino-terminus. The tetrameric structure appears to stabilize the association of the two domains and encloses a 12700 A3 spherical cavity. The tetramer contains six chloride ions, one buried in each S2 pocket and two at subunit interfaces.
-
-	Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain.,Olsen JG, Kadziola A, Lauritzen C, Pedersen J, Larsen S, Dahl SW FEBS Lett. 2001 Oct 12;506(3):201-6. PMID:11602245<ref>PMID:11602245</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jqp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]		*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
-	[[Category: Dipeptidyl-peptidase I]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dahl~~, S W~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Kadziola, A]]	+	[[Category: Dahl SW]]
-	[[Category: Larsen, S]]	+	[[Category: Kadziola A]]
-	[[Category: Lauritzen, C]]	+	[[Category: Larsen S]]
-	[[Category: Olsen~~, J G~~]]	+	[[Category: Lauritzen C]]
-	[[Category: Pedersen, J]]	+	[[Category: Olsen JG]]
-	~~[[Category: Cathepsin c]]~~	+	[[Category: Pedersen J]]
-	~~[[Category: Chloride]]~~	+
-	~~[[Category: Cysteine protease]]~~	+
-	~~[[Category: Dpp i]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Papain]]~~	+
-	~~[[Category: Tetramer~~]]	+

OCA at 06:49, 25 August 2021

OCA — Wed, 25 Aug 2021 06:49:59 GMT

←Older revision		Revision as of 06:49, 25 August 2021
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	<StructureSection load='1jqp' size='340' side='right'caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1jqp' size='340' side='right'caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [~~http~~://pdbe.org/1jqp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jqp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [https://pdbe.org/1jqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [https://www.ebi.ac.uk/pdbsum/1jqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CATC_RAT CATC_RAT]] Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).	+	[[https://www.uniprot.org/uniprot/CATC_RAT CATC_RAT]] Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:52, 20 November 2019

OCA — Wed, 20 Nov 2019 18:52:03 GMT

←Older revision		Revision as of 18:52, 20 November 2019
Line 1:		Line 1:

	==dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family==		==dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family==
-	<StructureSection load='1jqp' size='340' side='right' caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1jqp' size='340' side='right'caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQP FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1jqp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jqp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Dipeptidyl-peptidase I]]		[[Category: Dipeptidyl-peptidase I]]
		+	[[Category: Large Structures]]
	[[Category: Dahl, S W]]		[[Category: Dahl, S W]]
	[[Category: Kadziola, A]]		[[Category: Kadziola, A]]

OCA at 06:43, 15 February 2018

OCA — Thu, 15 Feb 2018 06:43:45 GMT

←Older revision		Revision as of 06:43, 15 February 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1jqp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jqp" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cathepsin\|Cathepsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:58, 4 October 2017

OCA — Wed, 04 Oct 2017 09:58:31 GMT

←Older revision		Revision as of 09:58, 4 October 2017
Line 1:		Line 1:
		+
	==dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family==		==dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family==
	<StructureSection load='1jqp' size='340' side='right' caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1jqp' size='340' side='right' caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://pdbe.org/1jqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://pdbe.org/1jqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Cathepsin\|Cathepsin]]		*[[Cathepsin\|Cathepsin]]
-	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:25, 11 September 2015

OCA — Fri, 11 Sep 2015 13:25:11 GMT

←Older revision		Revision as of 13:25, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jqp' size='340' side='right' caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1jqp' size='340' side='right' caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://pdbe.org/1jqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jqp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Dipeptidyl-peptidase I]]		[[Category: Dipeptidyl-peptidase I]]
-	[[Category: Rattus norvegicus]]
	[[Category: Dahl, S W]]		[[Category: Dahl, S W]]
	[[Category: Kadziola, A]]		[[Category: Kadziola, A]]

OCA at 17:01, 25 December 2014

OCA — Thu, 25 Dec 2014 17:01:49 GMT

←Older revision		Revision as of 17:01, 25 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CATC_RAT CATC_RAT]] Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Dipeptidyl-peptidase I]]		[[Category: Dipeptidyl-peptidase I]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Dahl, S W.]]	+	[[Category: Dahl, S W]]
-	[[Category: Kadziola, A.]]	+	[[Category: Kadziola, A]]
-	[[Category: Larsen, S.]]	+	[[Category: Larsen, S]]
-	[[Category: Lauritzen, C.]]	+	[[Category: Lauritzen, C]]
-	[[Category: Olsen, J G.]]	+	[[Category: Olsen, J G]]
-	[[Category: Pedersen, J.]]	+	[[Category: Pedersen, J]]
	[[Category: Cathepsin c]]		[[Category: Cathepsin c]]
	[[Category: Chloride]]		[[Category: Chloride]]

OCA at 11:32, 28 September 2014

OCA — Sun, 28 Sep 2014 11:32:57 GMT

←Older revision		Revision as of 11:32, 28 September 2014
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-	[[~~Image~~:1jqp.~~png\|left~~\|200px]]	+	==dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family==
		+	<StructureSection load='1jqp' size='340' side='right' caption='[[1jqp]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of mature dipeptidyl peptidase I reveals insight into the unique tetrameric structure, substrate binding and activation of this atypical papain family peptidase. Each subunit is composed of three peptides. The heavy and light chains form the catalytic domain, which adopts the papain fold. The residual pro-part forms a beta-barrel with the carboxylate group of Asp1 pointing towards the substrate amino-terminus. The tetrameric structure appears to stabilize the association of the two domains and encloses a 12700 A3 spherical cavity. The tetramer contains six chloride ions, one buried in each S2 pocket and two at subunit interfaces.

-	~~{{STRUCTURE_1jqp\| PDB=1jqp \| SCENE= }}~~	+	Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain.,Olsen JG, Kadziola A, Lauritzen C, Pedersen J, Larsen S, Dahl SW FEBS Lett. 2001 Oct 12;506(3):201-6. PMID:11602245<ref>PMID:11602245</ref>

-	~~===dipeptidyl peptidase I (cathepsin C)~~, a ~~tetrameric cysteine protease~~ of the ~~papain family===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11602245}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jqp]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA].~~	+

	==See Also==		==See Also==
	*[[Cathepsin\|Cathepsin]]		*[[Cathepsin\|Cathepsin]]
	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]		*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011602245<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dipeptidyl-peptidase I]]		[[Category: Dipeptidyl-peptidase I]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA at 19:12, 20 October 2012

OCA — Sat, 20 Oct 2012 19:12:55 GMT

←Older revision		Revision as of 19:12, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1jqp]] is a 1 chain structure ~~of [[Cathepsin]] and [[Dipeptidyl peptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA].	+	[[1jqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQP OCA].

	==See Also==		==See Also==

OCA at 06:38, 27 July 2012

OCA — Fri, 27 Jul 2012 06:38:39 GMT

←Older revision		Revision as of 06:38, 27 July 2012
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	[[Image:1jqp.png\|left\|200px]]		[[Image:1jqp.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_1jqp\| PDB=1jqp \| SCENE= }}		{{STRUCTURE_1jqp\| PDB=1jqp \| SCENE= }}

	===dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family===		===dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11602245}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11602245 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11602245}}		{{ABSTRACT_PUBMED_11602245}}

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	==See Also==		==See Also==
-	*[[Cathepsin]]	+	*[[Cathepsin\|Cathepsin]]
-	*[[Dipeptidyl peptidase]]	+	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11602245~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011602245</ref><references group="xtra"/>
	[[Category: Dipeptidyl-peptidase I]]		[[Category: Dipeptidyl-peptidase I]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]