1jr1 - Revision history

OCA at 07:54, 3 April 2024

OCA — Wed, 03 Apr 2024 07:54:05 GMT

←Older revision		Revision as of 07:54, 3 April 2024
Line 3:		Line 3:
	<StructureSection load='1jr1' size='340' side='right'caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1jr1' size='340' side='right'caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cho_cell_lines Cho cell lines~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>~~, ~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [https://pdbe.org/1jr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [https://pdbe.org/1jr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IMDH2_CRIGR IMDH2_CRIGR]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]	+	[https://www.uniprot.org/uniprot/IMDH2_CRIGR IMDH2_CRIGR] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jr1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jr1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.
-
-	Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.,Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP Cell. 1996 Jun 14;85(6):921-30. PMID:8681386<ref>PMID:8681386</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jr1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Inosine monophosphate dehydrogenase 3D structures\|Inosine monophosphate dehydrogenase 3D structures]]		*[[Inosine monophosphate dehydrogenase 3D structures\|Inosine monophosphate dehydrogenase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cho cell lines]]~~	+	[[Category: Cricetulus griseus]]
-	~~[[Category: IMP dehydrogenase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Caron~~, P R~~]]	+	[[Category: Caron PR]]
-	[[Category: Chambers~~, S P~~]]	+	[[Category: Chambers SP]]
-	[[Category: Fleming~~, M A~~]]	+	[[Category: Fleming MA]]
-	[[Category: Futer, O]]	+	[[Category: Futer O]]
-	[[Category: Murcko~~, M A~~]]	+	[[Category: Murcko MA]]
-	[[Category: Raybuck~~, S A~~]]	+	[[Category: Raybuck SA]]
-	[[Category: Sintchak~~, M D~~]]	+	[[Category: Sintchak MD]]
-	[[Category: Wilson~~, K P]]~~	+	[[Category: Wilson KP]]
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Guanine nucleotide synthesis]]~~	+
-	~~[[Category: Impd]]~~	+
-	~~[[Category: Impdh]]~~	+
-	~~[[Category: Mpa]]~~	+
-	~~[[Category: Mycophenolic acid]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:21, 14 April 2021

OCA — Wed, 14 Apr 2021 07:21:32 GMT

←Older revision		Revision as of 07:21, 14 April 2021
Line 3:		Line 3:
	<StructureSection load='1jr1' size='340' side='right'caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1jr1' size='340' side='right'caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cho_cell_lines Cho cell lines]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cho_cell_lines Cho cell lines]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [~~http~~://pdbe.org/1jr1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [https://pdbe.org/1jr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IMDH2_CRIGR IMDH2_CRIGR]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]	+	[[https://www.uniprot.org/uniprot/IMDH2_CRIGR IMDH2_CRIGR]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Inosine monophosphate dehydrogenase\|Inosine monophosphate dehydrogenase]]	+	*[[Inosine monophosphate dehydrogenase 3D structures\|Inosine monophosphate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:54, 10 July 2019

OCA — Wed, 10 Jul 2019 06:54:33 GMT

←Older revision		Revision as of 06:54, 10 July 2019
Line 1:		Line 1:

	==Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid==		==Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid==
-	<StructureSection load='1jr1' size='340' side='right' caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1jr1' size='340' side='right'caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cho_cell_lines Cho cell lines]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cho_cell_lines Cho cell lines]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jr1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jr1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Cho cell lines]]		[[Category: Cho cell lines]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Caron, P R]]		[[Category: Caron, P R]]
	[[Category: Chambers, S P]]		[[Category: Chambers, S P]]

OCA at 09:45, 4 October 2017

OCA — Wed, 04 Oct 2017 09:45:36 GMT

←Older revision		Revision as of 09:45, 4 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid==		==Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid==
	<StructureSection load='1jr1' size='340' side='right' caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1jr1' size='340' side='right' caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://pdbe.org/1jr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://pdbe.org/1jr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jr1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:45, 11 September 2015

OCA — Fri, 11 Sep 2015 09:45:21 GMT

←Older revision		Revision as of 09:45, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jr1' size='340' side='right' caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1jr1' size='340' side='right' caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cricetulus_griseus Cricetulus griseus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cho_cell_lines Cho cell lines]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://pdbe.org/1jr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jr1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Inosine monophosphate dehydrogenase\|Inosine monophosphate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cricetulus griseus~~]]	+	[[Category: Cho cell lines]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
	[[Category: Caron, P R]]		[[Category: Caron, P R]]

OCA at 14:41, 25 December 2014

OCA — Thu, 25 Dec 2014 14:41:24 GMT

←Older revision		Revision as of 14:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IMDH2_CRIGR IMDH2_CRIGR]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Cricetulus griseus]]		[[Category: Cricetulus griseus]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
-	[[Category: Caron, P R.]]	+	[[Category: Caron, P R]]
-	[[Category: Chambers, S P.]]	+	[[Category: Chambers, S P]]
-	[[Category: Fleming, M A.]]	+	[[Category: Fleming, M A]]
-	[[Category: Futer, O.]]	+	[[Category: Futer, O]]
-	[[Category: Murcko, M A.]]	+	[[Category: Murcko, M A]]
-	[[Category: Raybuck, S A.]]	+	[[Category: Raybuck, S A]]
-	[[Category: Sintchak, M D.]]	+	[[Category: Sintchak, M D]]
-	[[Category: Wilson, K P.]]	+	[[Category: Wilson, K P]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Guanine nucleotide synthesis]]		[[Category: Guanine nucleotide synthesis]]

OCA at 13:58, 28 September 2014

OCA — Sun, 28 Sep 2014 13:58:09 GMT

←Older revision		Revision as of 13:58, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jr1.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid==
		+	<StructureSection load='1jr1' size='340' side='right' caption='[[1jr1]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ak5\|1ak5]], [[1b3o\|1b3o]], [[1zfj\|1zfj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jr1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.

-	~~{{STRUCTURE_1jr1\| PDB=1jr1 \| SCENE= }}~~	+	Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.,Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP Cell. 1996 Jun 14;85(6):921-30. PMID:8681386<ref>PMID:8681386</ref>

-	~~===Crystal structure~~ of ~~Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8681386}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jr1]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cricetulus_griseus Cricetulus griseus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008681386<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cricetulus griseus]]		[[Category: Cricetulus griseus]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]

OCA: Protected "1jr1" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:18:10 GMT

Protected "1jr1" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:18, 5 December 2012

OCA at 11:18, 5 December 2012

OCA — Wed, 05 Dec 2012 11:18:04 GMT

←Older revision		Revision as of 11:18, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jr1.png\|left\|200px]]		[[Image:1jr1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jr1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jr1\| PDB=1jr1 \| SCENE= }}		{{STRUCTURE_1jr1\| PDB=1jr1 \| SCENE= }}

	===Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid===		===Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8681386}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8681386 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8681386}}		{{ABSTRACT_PUBMED_8681386}}

	==About this Structure==		==About this Structure==
-	~~1JR1~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].	+	[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8681386~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008681386</ref><references group="xtra"/>
	[[Category: Cricetulus griseus]]		[[Category: Cricetulus griseus]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
Line 40:		Line 28:
	[[Category: Mpa]]		[[Category: Mpa]]
	[[Category: Mycophenolic acid]]		[[Category: Mycophenolic acid]]
-		+	[[Category: Oxidoreductase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 18:58:01 2009''~~	+

OCA at 16:58, 17 February 2009

OCA — Tue, 17 Feb 2009 16:58:02 GMT

←Older revision		Revision as of 16:58, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1JR1 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].	+	1JR1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].

	==Reference==		==Reference==
-	Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid., Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP, Cell. 1996 Jun 14;85(6):921-30. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/8681386 8681386]~~	+	<ref group="xtra">PMID:8681386</ref><references group="xtra"/>
	[[Category: Cricetulus griseus]]		[[Category: Cricetulus griseus]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
-	[[Category: Single protein]]
	[[Category: Caron, P R.]]		[[Category: Caron, P R.]]
	[[Category: Chambers, S P.]]		[[Category: Chambers, S P.]]
Line 42:		Line 41:
	[[Category: Mycophenolic acid]]		[[Category: Mycophenolic acid]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 1 20~~:40:~~22 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:58:01 2009''