1jtz - Revision history

OCA at 08:46, 16 August 2023

OCA — Wed, 16 Aug 2023 08:46:22 GMT

←Older revision		Revision as of 08:46, 16 August 2023
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	<StructureSection load='1jtz' size='340' side='right'caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1jtz' size='340' side='right'caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RANKL (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [~~http~~://pdbe.org/1jtz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jtz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [https://pdbe.org/1jtz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [https://www.ebi.ac.uk/pdbsum/1jtz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.	+	[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.	+	[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Fremont~~, D H~~]]	+	[[Category: Fremont DH]]
-	[[Category: Nelson~~, C A]]~~	+	[[Category: Nelson CA]]
-	~~[[Category: Beta-sandwich]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Jellyroll]]~~	+
-	~~[[Category: Tumor necrosis factor superfamily member~~]]	+

OCA at 07:35, 25 November 2020

OCA — Wed, 25 Nov 2020 07:35:45 GMT

←Older revision		Revision as of 07:35, 25 November 2020
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	==CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.==		==CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.==
-	<StructureSection load='1jtz' size='340' side='right' caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1jtz' size='340' side='right'caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://pdbe.org/1jtz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://pdbe.org/1jtz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jtz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jtz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Tumor necrosis factor ligand superfamily\|Tumor necrosis factor ligand superfamily]]	+	*[[Tumor necrosis factor ligand superfamily 3D structures\|Tumor necrosis factor ligand superfamily 3D structures]]
-	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]	+	*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Fremont, D H]]		[[Category: Fremont, D H]]

OCA at 09:56, 4 October 2017

OCA — Wed, 04 Oct 2017 09:56:31 GMT

←Older revision		Revision as of 09:56, 4 October 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.==		==CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.==
	<StructureSection load='1jtz' size='340' side='right' caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1jtz' size='340' side='right' caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://pdbe.org/1jtz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://pdbe.org/1jtz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jtz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:

	==See Also==		==See Also==
		+	*[[Tumor necrosis factor ligand superfamily\|Tumor necrosis factor ligand superfamily]]
	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]		*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	== References ==		== References ==

OCA at 12:07, 11 September 2015

OCA — Fri, 11 Sep 2015 12:07:58 GMT

←Older revision		Revision as of 12:07, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jtz' size='340' side='right' caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1jtz' size='340' side='right' caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://pdbe.org/1jtz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jtz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Fremont, D H]]		[[Category: Fremont, D H]]
	[[Category: Nelson, C A]]		[[Category: Nelson, C A]]

OCA at 12:23, 2 January 2015

OCA — Fri, 02 Jan 2015 12:23:20 GMT

←Older revision		Revision as of 12:23, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.		[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Fremont, D H.]]	+	[[Category: Fremont, D H]]
-	[[Category: Nelson, C A.]]	+	[[Category: Nelson, C A]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Jellyroll]]		[[Category: Jellyroll]]
	[[Category: Tumor necrosis factor superfamily member]]		[[Category: Tumor necrosis factor superfamily member]]

OCA at 15:03, 29 September 2014

OCA — Mon, 29 Sep 2014 15:03:38 GMT

←Older revision		Revision as of 15:03, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1jtz\| PDB~~=1jtz \| ~~SCENE~~= }}	+	==CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.==
-	===~~CRYSTAL STRUCTURE OF TRANCE~~/RANKL ~~CYTOKINE~~.===	+	<StructureSection load='1jtz' size='340' side='right' caption='[[1jtz]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_11581298}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTZ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RANKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jtz RCSB], [http://www.ebi.ac.uk/pdbsum/1jtz PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.		[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.		[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jtz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RANK, the receptor activator of NF-kappaB, and its ligand RANKL (initially termed TRANCE, also termed ODF and OPGL), are a TNF superfamily receptor-ligand pair that govern the development and function of osteoclasts, lymphoid tissue, and mammary epithelium. While TNF family cytokines share a common structural scaffold, individual receptor-ligand pairs associate with high specificity. Given the low level of amino acid conservation among members of the TNF superfamily, the means by which these molecules achieve specificity cannot be completely understood without knowledge of their three-dimensional structures. To determine the elements of RANKL that mediate RANK activation, we have crystallized the ectodomain of murine RANKL and solved its structure to a resolution of 2.6 A. RANKL self-associates as a homotrimer with four unique surface loops that distinguish it from other TNF family cytokines. Mutagenesis of selected residues in these loops significantly modulates RANK activation, as evidenced by in vitro osteoclastogenesis, thereby establishing their necessity in mediating the biological activities of RANKL. Such structural determinants of RANKL-RANK specificity may be of relevance in the pharmacologic design of compounds to ameliorate osteopenic disorders of bone.

-	~~==About this Structure==~~	+	Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity.,Lam J, Nelson CA, Ross FP, Teitelbaum SL, Fremont DH J Clin Invest. 2001 Oct;108(7):971-9. PMID:11581298<ref>PMID:11581298</ref>
-	~~[[1jtz]] is a 3 chain~~ structure ~~with sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:011581298</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Fremont, D H.]]		[[Category: Fremont, D H.]]

OCA at 16:12, 24 March 2013

OCA — Sun, 24 Mar 2013 16:12:15 GMT

←Older revision		Revision as of 16:12, 24 March 2013
Line 1:		Line 1:
-	[[Image:1jtz.png\|left\|200px]]
-
	{{STRUCTURE_1jtz\| PDB=1jtz \| SCENE= }}		{{STRUCTURE_1jtz\| PDB=1jtz \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.===		===CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.===
		+	{{ABSTRACT_PUBMED_11581298}}

-	~~{{ABSTRACT_PUBMED_11581298}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011581298</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011581298</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Fremont, D H.]]		[[Category: Fremont, D H.]]

OCA: Protected "1jtz" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:32:39 GMT

Protected "1jtz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:32, 5 December 2012

OCA at 11:32, 5 December 2012

OCA — Wed, 05 Dec 2012 11:32:37 GMT

←Older revision		Revision as of 11:32, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jtz.png\|left\|200px]]		[[Image:1jtz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jtz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jtz\| PDB=1jtz \| SCENE= }}		{{STRUCTURE_1jtz\| PDB=1jtz \| SCENE= }}

	===CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.===		===CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11581298}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11581298 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11581298}}		{{ABSTRACT_PUBMED_11581298}}

	==About this Structure==		==About this Structure==
-	~~1JTZ~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA].	+	[[1jtz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11581298~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011581298</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Fremont, D H.]]		[[Category: Fremont, D H.]]
	[[Category: Nelson, C A.]]		[[Category: Nelson, C A.]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
		+	[[Category: Cytokine]]
	[[Category: Jellyroll]]		[[Category: Jellyroll]]
	[[Category: Tumor necrosis factor superfamily member]]		[[Category: Tumor necrosis factor superfamily member]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:28:36 2009''

OCA at 19:28, 17 February 2009

OCA — Tue, 17 Feb 2009 19:28:36 GMT

←Older revision		Revision as of 19:28, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1JTZ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA].	+	1JTZ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTZ OCA].

	==Reference==		==Reference==
-	~~Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity., Lam J, Nelson CA, Ross FP, Teitelbaum SL, Fremont DH, J Clin Invest. 2001 Oct;108(7):971-9.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11581298 11581298]~~	+	<ref group="xtra">PMID:11581298</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Fremont, D H.]]		[[Category: Fremont, D H.]]
	[[Category: Nelson, C A.]]		[[Category: Nelson, C A.]]
Line 32:		Line 31:
	[[Category: Tumor necrosis factor superfamily member]]		[[Category: Tumor necrosis factor superfamily member]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 1 20~~:51:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:28:36 2009''