1ju1 - Revision history

OCA at 18:44, 29 November 2023

OCA — Wed, 29 Nov 2023 18:44:03 GMT

←Older revision		Revision as of 18:44, 29 November 2023
Line 1:		Line 1:

	==Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex==		==Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex==
-	<StructureSection load='1ju1' size='340' side='right'caption='[[1ju1~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1ju1' size='340' side='right'caption='[[1ju1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [https://pdbe.org/1ju1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ju1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [https://pdbe.org/1ju1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ju1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju1 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barbault, F]]	+	[[Category: Barbault F]]
-	[[Category: Girard, F]]	+	[[Category: Girard F]]
-	[[Category: Lancelot, G]]	+	[[Category: Lancelot G]]
-	~~[[Category: Dimer initiation sequence]]~~	+
-	~~[[Category: Extended duplex]]~~	+
-	~~[[Category: Hiv]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Sl1]]~~	+
-	~~[[Category: Stable dimer~~]]	+

OCA at 07:22, 14 April 2021

OCA — Wed, 14 Apr 2021 07:22:11 GMT

←Older revision		Revision as of 07:22, 14 April 2021
Line 3:		Line 3:
	<StructureSection load='1ju1' size='340' side='right'caption='[[1ju1]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1ju1' size='340' side='right'caption='[[1ju1]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [~~http~~://pdbe.org/1ju1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ju1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [https://pdbe.org/1ju1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ju1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:03, 10 July 2019

OCA — Wed, 10 Jul 2019 07:03:16 GMT

←Older revision		Revision as of 07:03, 10 July 2019
Line 1:		Line 1:

	==Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex==		==Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex==
-	<StructureSection load='1ju1' size='340' side='right' caption='[[1ju1]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1ju1' size='340' side='right'caption='[[1ju1]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Barbault, F]]		[[Category: Barbault, F]]
	[[Category: Girard, F]]		[[Category: Girard, F]]

OCA at 09:54, 4 October 2017

OCA — Wed, 04 Oct 2017 09:54:45 GMT

←Older revision		Revision as of 09:54, 4 October 2017
Line 1:		Line 1:
		+
	==Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex==		==Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex==
	<StructureSection load='1ju1' size='340' side='right' caption='[[1ju1]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1ju1' size='340' side='right' caption='[[1ju1]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [http://pdbe.org/1ju1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ju1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [http://pdbe.org/1ju1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ju1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:04, 10 September 2015

OCA — Thu, 10 Sep 2015 04:04:21 GMT

←Older revision		Revision as of 04:04, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ju1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [http://pdbe.org/1ju1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ju1 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ju1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:16, 22 December 2014

OCA — Mon, 22 Dec 2014 05:16:01 GMT

←Older revision		Revision as of 05:16, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ju1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ju1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Barbault, F.]]	+	[[Category: Barbault, F]]
-	[[Category: Girard, F.]]	+	[[Category: Girard, F]]
-	[[Category: Lancelot, G.]]	+	[[Category: Lancelot, G]]
	[[Category: Dimer initiation sequence]]		[[Category: Dimer initiation sequence]]
	[[Category: Extended duplex]]		[[Category: Extended duplex]]

OCA at 05:49, 8 June 2014

OCA — Sun, 08 Jun 2014 05:49:51 GMT

←Older revision		Revision as of 05:49, 8 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1ju1.~~png~~\|~~left~~\|~~200px~~]]	+	==Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex==
		+	<StructureSection load='1ju1' size='340' side='right' caption='[[1ju1]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JU1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jtj\|1jtj]], [[1ju0\|1ju0]], [[1jua\|1jua]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ju1 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The genome of all retrovirus consists of two copies of genomic RNA which are noncovalently linked near their 5' end. A sequence localized immediately upstream from the splice donor site inside the HIV-1 psi-RNA region was identified as the domain responsible for the dimerization initiation. It was shown that a kissing complex and a stable dimer are both involved in the HIV-1Lai RNA dimerization process in vitro. The NCp7 protein activates the dimerization by converting a transient loop-loop complex into a more stable dimer. The structure of this transitory loop-loop complex was recently elucidated by Mujeeb et al. In work presented here, we use NMR spectroscopy to determine the stable extended dimer structure formed from a 23 nucleotides RNA fragment, part of the 35 nucleotides SL1 sequence. By heating to 90 degrees C, then slowly cooling this sequence, we were able to show that an extended dimer is formed. We present evidence for the three dimensional structure of this dimer. NMR data yields evidence for a zipper like motif A8A9.A16 existence. This motif enables the surrounding bases to be positioned more closely and permit the G7 and C17 bases to be paired. This is different to other related sequences where only the kissing complex is observed, we suggest that the zipper like motif AA.A could be an important stabilization factor of the extended duplex.

-	~~{{STRUCTURE_1ju1\| PDB=1ju1 \| SCENE= }}~~	+	Dimer initiation sequence of HIV-1Lai genomic RNA: NMR solution structure of the extended duplex.,Girard F, Barbault F, Gouyette C, Huynh-Dinh T, Paoletti J, Lancelot G J Biomol Struct Dyn. 1999 Jun;16(6):1145-57. PMID:10447199<ref>PMID:10447199</ref>

-	~~===Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure~~ of the ~~Extended Duplex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10447199}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ju1]] is a 2 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1JU1 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010447199<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Barbault, F.]]		[[Category: Barbault, F.]]
	[[Category: Girard, F.]]		[[Category: Girard, F.]]

OCA: Protected "1ju1" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 15:22:25 GMT

Protected "1ju1" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:22, 14 August 2012

OCA at 15:22, 14 August 2012

OCA — Tue, 14 Aug 2012 15:22:24 GMT

←Older revision		Revision as of 15:22, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1ju1.png\|left\|200px]]		[[Image:1ju1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ju1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ju1\| PDB=1ju1 \| SCENE= }}		{{STRUCTURE_1ju1\| PDB=1ju1 \| SCENE= }}

	===Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex===		===Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10447199}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10447199 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10447199}}		{{ABSTRACT_PUBMED_10447199}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA].	+	[[1ju1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA].

	==Reference==		==Reference==
-	Dimer initiation sequence of HIV-1Lai genomic RNA: NMR solution structure of the extended duplex., Girard F, Barbault F, Gouyette C, Huynh-Dinh T, Paoletti J, Lancelot G, J Biomol Struct Dyn. 1999 Jun;16(6):1145-57. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~10447199 10447199]~~	+	<ref group="xtra">PMID:010447199</ref><references group="xtra"/>
	[[Category: Barbault, F.]]		[[Category: Barbault, F.]]
	[[Category: Girard, F.]]		[[Category: Girard, F.]]
Line 33:		Line 21:
	[[Category: Sl1]]		[[Category: Sl1]]
	[[Category: Stable dimer]]		[[Category: Stable dimer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:51:38 2008''

OCA at 17:51, 1 July 2008

OCA — Tue, 01 Jul 2008 17:51:43 GMT

←Older revision		Revision as of 17:51, 1 July 2008
Line 1:		Line 1:
-	[[Image:1ju1.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1ju1.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1ju1\| PDB=1ju1 \| SCENE= }}		{{STRUCTURE_1ju1\| PDB=1ju1 \| SCENE= }}

-	~~'''~~Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex~~'''~~	+	===Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex===


-	~~==Overview==~~	+	<!--
-	~~The genome of all retrovirus consists of two copies of genomic RNA which are noncovalently linked near their 5' end. A sequence localized immediately upstream from the splice donor site inside the HIV~~-~~1 psi~~-RNA region was identified as the domain responsible for the dimerization initiation. It was shown that a kissing complex and a stable dimer are both involved in the HIV-1Lai RNA dimerization process in vitro. The ~~NCp7 protein activates the dimerization by converting a transient loop-loop complex into a more stable dimer. The structure of~~ this ~~transitory loop-loop complex was recently elucidated by Mujeeb et al. In work presented here~~, ~~we use NMR spectroscopy to determine the stable extended dimer structure formed from a 23 nucleotides RNA fragment~~, ~~part of~~ the ~~35 nucleotides SL1 sequence. By heating~~ to ~~90 degrees C, then slowly cooling this sequence, we were able to show that an extended dimer is formed. We present evidence for~~ the ~~three dimensional structure of this dimer~~. ~~NMR data yields evidence for a zipper like motif A8A9~~.~~A16 existence. This motif enables the surrounding bases to be positioned more closely and permit the G7 and C17 bases to be paired. This is different to other related sequences~~ where ~~only the kissing complex~~ is ~~observed, we suggest that~~ the ~~zipper like motif AA.A could be an important stabilization factor of the extended duplex~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_10447199}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10447199 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10447199}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU1 OCA].

	==Reference==		==Reference==
Line 29:		Line 33:
	[[Category: Sl1]]		[[Category: Sl1]]
	[[Category: Stable dimer]]		[[Category: Stable dimer]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 21~~:55:16 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:51:38 2008''