1juo - Revision history

OCA at 07:42, 7 February 2024

OCA — Wed, 07 Feb 2024 07:42:19 GMT

←Older revision		Revision as of 07:42, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='1juo' size='340' side='right'caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1juo' size='340' side='right'caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [https://pdbe.org/1juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [https://www.ebi.ac.uk/pdbsum/1juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1juo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [https://pdbe.org/1juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [https://www.ebi.ac.uk/pdbsum/1juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1juo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SORCN_HUMAN SORCN_HUMAN]] Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.<ref>PMID:17699613</ref>	+	[https://www.uniprot.org/uniprot/SORCN_HUMAN SORCN_HUMAN] Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.<ref>PMID:17699613</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1juo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1juo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Sorcin is a 22 kD calcium-binding protein that is found in a wide variety of cell types, such as heart, muscle, brain and adrenal medulla. It belongs to the penta-EF-hand (PEF) protein family, which contains five EF-hand motifs that associate with membranes in a calcium-dependent manner. Prototypic members of this family are the calcium-binding domains of calpain, such as calpain dVI. Full-length human sorcin has been crystallized in the absence of calcium and the structure determined at 2.2 A resolution. Apart from an extended N-terminal portion, the sorcin molecule has a globular shape. The C-terminal domain is predominantly alpha-helical, containing eight alpha-helices and connecting loops incorporating five EF hands. Sorcin forms dimers through the association of the unpaired EF5, confirming this as the mode of association in the dimerization of PEF proteins. Comparison with calpain dVI reveals that the general folds of the individual EF-hand motifs are conserved, especially that of EF1, the novel EF-hand motif characteristic of the family. Detailed structural comparisons of sorcin with other members of PEF indicate that the EF-hand pair EF1-EF2 is likely to correspond to the two physiologically relevant calcium-binding sites and that the calcium-induced conformational change may be modest and localized within this pair of EF-hands. Overall, the results derived from the structural observations support the view that, in sorcin, calcium signaling takes place through the first pair of EF-hands.
-
-	Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family.,Xie X, Dwyer MD, Swenson L, Parker MH, Botfield MC Protein Sci. 2001 Dec;10(12):2419-25. PMID:11714909<ref>PMID:11714909</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1juo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Xie, X]]	+	[[Category: Xie X]]
-	~~[[Category: Calcium-binding protein]]~~	+
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Pef]]~~	+
-	~~[[Category: Penta-ef-hand~~]]	+

OCA at 06:45, 11 August 2021

OCA — Wed, 11 Aug 2021 06:45:47 GMT

←Older revision		Revision as of 06:45, 11 August 2021
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	<StructureSection load='1juo' size='340' side='right'caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1juo' size='340' side='right'caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [~~http~~://pdbe.org/1juo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1juo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1juo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [https://pdbe.org/1juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [https://www.ebi.ac.uk/pdbsum/1juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1juo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SORCN_HUMAN SORCN_HUMAN]] Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.<ref>PMID:17699613</ref>	+	[[https://www.uniprot.org/uniprot/SORCN_HUMAN SORCN_HUMAN]] Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.<ref>PMID:17699613</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:28, 6 November 2019

OCA — Wed, 06 Nov 2019 09:28:46 GMT

←Older revision		Revision as of 09:28, 6 November 2019
Line 1:		Line 1:

	==Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family==		==Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family==
-	<StructureSection load='1juo' size='340' side='right' caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1juo' size='340' side='right'caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Xie, X]]		[[Category: Xie, X]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]

OCA at 09:03, 17 January 2018

OCA — Wed, 17 Jan 2018 09:03:35 GMT

←Older revision		Revision as of 09:03, 17 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family==		==Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family==
	<StructureSection load='1juo' size='340' side='right' caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1juo' size='340' side='right' caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [http://pdbe.org/1juo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [http://www.ebi.ac.uk/pdbsum/1juo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [http://pdbe.org/1juo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [http://www.ebi.ac.uk/pdbsum/1juo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1juo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1juo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1juo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:21, 9 February 2016

OCA — Tue, 09 Feb 2016 15:21:46 GMT

←Older revision		Revision as of 15:21, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1juo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:32, 10 September 2015

OCA — Thu, 10 Sep 2015 23:32:21 GMT

←Older revision		Revision as of 23:32, 10 September 2015
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	<StructureSection load='1juo' size='340' side='right' caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1juo' size='340' side='right' caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [http://www.ebi.ac.uk/pdbsum/1juo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [http://pdbe.org/1juo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [http://www.ebi.ac.uk/pdbsum/1juo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1juo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Xie, X]]		[[Category: Xie, X]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]

OCA at 07:41, 25 December 2014

OCA — Thu, 25 Dec 2014 07:41:37 GMT

←Older revision		Revision as of 07:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [http://www.ebi.ac.uk/pdbsum/1juo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [http://www.ebi.ac.uk/pdbsum/1juo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SORCN_HUMAN SORCN_HUMAN]] Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.<ref>PMID:17699613</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Xie, X.]]	+	[[Category: Xie, X]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
	[[Category: Pef]]		[[Category: Pef]]
	[[Category: Penta-ef-hand]]		[[Category: Penta-ef-hand]]

OCA at 09:32, 28 September 2014

OCA — Sun, 28 Sep 2014 09:32:05 GMT

←Older revision		Revision as of 09:32, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1juo.~~png\|left~~\|200px]]	+	==Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family==
		+	<StructureSection load='1juo' size='340' side='right' caption='[[1juo]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1juo RCSB], [http://www.ebi.ac.uk/pdbsum/1juo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1juo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sorcin is a 22 kD calcium-binding protein that is found in a wide variety of cell types, such as heart, muscle, brain and adrenal medulla. It belongs to the penta-EF-hand (PEF) protein family, which contains five EF-hand motifs that associate with membranes in a calcium-dependent manner. Prototypic members of this family are the calcium-binding domains of calpain, such as calpain dVI. Full-length human sorcin has been crystallized in the absence of calcium and the structure determined at 2.2 A resolution. Apart from an extended N-terminal portion, the sorcin molecule has a globular shape. The C-terminal domain is predominantly alpha-helical, containing eight alpha-helices and connecting loops incorporating five EF hands. Sorcin forms dimers through the association of the unpaired EF5, confirming this as the mode of association in the dimerization of PEF proteins. Comparison with calpain dVI reveals that the general folds of the individual EF-hand motifs are conserved, especially that of EF1, the novel EF-hand motif characteristic of the family. Detailed structural comparisons of sorcin with other members of PEF indicate that the EF-hand pair EF1-EF2 is likely to correspond to the two physiologically relevant calcium-binding sites and that the calcium-induced conformational change may be modest and localized within this pair of EF-hands. Overall, the results derived from the structural observations support the view that, in sorcin, calcium signaling takes place through the first pair of EF-hands.

-	~~{{STRUCTURE_1juo\| PDB=1juo \| SCENE= }}~~	+	Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family.,Xie X, Dwyer MD, Swenson L, Parker MH, Botfield MC Protein Sci. 2001 Dec;10(12):2419-25. PMID:11714909<ref>PMID:11714909</ref>

-	~~===Crystal Structure of Calcium-free Human Sorcin: A Member~~ of the ~~Penta-EF-Hand Protein Family===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11714909}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1juo]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011714909<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Xie, X.]]		[[Category: Xie, X.]]

OCA: Protected "1juo" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:14:58 GMT

Protected "1juo" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:14, 5 December 2012

OCA at 11:14, 5 December 2012

OCA — Wed, 05 Dec 2012 11:14:54 GMT

←Older revision		Revision as of 11:14, 5 December 2012
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-	{{Seed}}
	[[Image:1juo.png\|left\|200px]]		[[Image:1juo.png\|left\|200px]]

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	{{STRUCTURE_1juo\| PDB=1juo \| SCENE= }}		{{STRUCTURE_1juo\| PDB=1juo \| SCENE= }}

	===Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family===		===Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11714909}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_11714909}}		{{ABSTRACT_PUBMED_11714909}}

	==About this Structure==		==About this Structure==
-	~~1JUO~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA].	+	[[1juo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11714909~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011714909</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Xie, X.]]		[[Category: Xie, X.]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]
		+	[[Category: Metal transport]]
	[[Category: Pef]]		[[Category: Pef]]
	[[Category: Penta-ef-hand]]		[[Category: Penta-ef-hand]]
-	[[Category: X-ray]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:47:26 2009''