1jv3 - Revision history

OCA at 07:15, 25 October 2023

OCA — Wed, 25 Oct 2023 07:15:56 GMT

←Older revision		Revision as of 07:15, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1jv3' size='340' side='right'caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1jv3' size='340' side='right'caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=UD2:URIDINE~~-~~DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [https://pdbe.org/1jv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1jv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jv3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [~~http~~://pdbe.org/1jv3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jv3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jv3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/UAP1_HUMAN UAP1_HUMAN]] Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.	+	[https://www.uniprot.org/uniprot/UAP1_HUMAN UAP1_HUMAN] Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bourne, Y]]	+	[[Category: Bourne Y]]
-	[[Category: Peneff, C]]	+	[[Category: Peneff C]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Nucleotidyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:36, 25 November 2020

OCA — Wed, 25 Nov 2020 07:36:13 GMT

←Older revision		Revision as of 07:36, 25 November 2020
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	==CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC==		==CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC==
-	<StructureSection load='1jv3' size='340' side='right' caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1jv3' size='340' side='right'caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://pdbe.org/1jv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jv3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://pdbe.org/1jv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jv3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jv3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Peneff, C]]		[[Category: Peneff, C]]

OCA at 07:20, 11 October 2017

OCA — Wed, 11 Oct 2017 07:20:46 GMT

←Older revision		Revision as of 07:20, 11 October 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC==		==CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC==
	<StructureSection load='1jv3' size='340' side='right' caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1jv3' size='340' side='right' caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://pdbe.org/1jv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://pdbe.org/1jv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jv3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 36:		Line 37:
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Peneff, C]]		[[Category: Peneff, C]]
		+	[[Category: Alternative splicing]]
	[[Category: Nucleotidyltransferase]]		[[Category: Nucleotidyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 01:46, 12 September 2015

OCA — Sat, 12 Sep 2015 01:46:22 GMT

←Older revision		Revision as of 01:46, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1jv3' size='340' side='right' caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1jv3' size='340' side='right' caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://pdbe.org/1jv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jv3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Peneff, C]]		[[Category: Peneff, C]]
	[[Category: Nucleotidyltransferase]]		[[Category: Nucleotidyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 22:12, 25 December 2014

OCA — Thu, 25 Dec 2014 22:12:56 GMT

←Older revision		Revision as of 22:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UAP1_HUMAN UAP1_HUMAN]] Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bourne, Y.]]	+	[[Category: Bourne, Y]]
-	[[Category: Peneff, C.]]	+	[[Category: Peneff, C]]
	[[Category: Nucleotidyltransferase]]		[[Category: Nucleotidyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 13:36, 28 September 2014

OCA — Sun, 28 Sep 2014 13:36:22 GMT

←Older revision		Revision as of 13:36, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jv3.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC==
		+	<StructureSection load='1jv3' size='340' side='right' caption='[[1jv3]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JV3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jv1\|1jv1]], [[1jvd\|1jvd]], [[1jvg\|1jvg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jv3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jv3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recently published human genome with its relatively modest number of genes has highlighted the importance of post-transcriptional and post-translational modifications, such as alternative splicing or glycosylation, in generating the complexities of human biology. The human UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylases AGX1 and AGX2, which differ in sequence by an alternatively spliced 17 residue peptide, are key enzymes synthesizing UDPGlcNAc, an essential precursor for protein glycosylation. To better understand the catalytic mechanism of these enzymes and the role of the alternatively spliced segment, we have solved the crystal structures of AGX1 and AGX2 in complexes with UDPGlcNAc (at 1.9 and 2.4 A resolution, respectively) and UDPGalNAc (at 2.2 and 2.3 A resolution, respectively). Comparison with known structures classifies AGX1 and AGX2 as two new members of the SpsA-GnT I Core superfamily and, together with mutagenesis analysis, helps identify residues critical for catalysis. Most importantly, our combined structural and biochemical data provide evidence for a change in the oligomeric assembly accompanied by a significant modification of the active site architecture, a result suggesting that the two isoforms generated by alternative splicing may have distinct catalytic properties.

-	~~{{STRUCTURE_1jv3\| PDB=1jv3 \| SCENE= }}~~	+	Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture.,Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y EMBO J. 2001 Nov 15;20(22):6191-202. PMID:11707391<ref>PMID:11707391</ref>

-	~~===CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11707391}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jv3]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011707391<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bourne, Y.]]		[[Category: Bourne, Y.]]

OCA: Protected "1jv3" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:22:12 GMT

Protected "1jv3" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:22, 5 December 2012

OCA at 11:22, 5 December 2012

OCA — Wed, 05 Dec 2012 11:22:10 GMT

←Older revision		Revision as of 11:22, 5 December 2012
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-	{{Seed}}
	[[Image:1jv3.png\|left\|200px]]		[[Image:1jv3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jv3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jv3\| PDB=1jv3 \| SCENE= }}		{{STRUCTURE_1jv3\| PDB=1jv3 \| SCENE= }}

	===CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC===		===CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11707391}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11707391 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11707391}}		{{ABSTRACT_PUBMED_11707391}}

	==About this Structure==		==About this Structure==
-	~~1JV3~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA].	+	[[1jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11707391~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011707391</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bourne, Y.]]		[[Category: Bourne, Y.]]
	[[Category: Peneff, C.]]		[[Category: Peneff, C.]]
-	[[Category: Alternative splicing]]
	[[Category: Nucleotidyltransferase]]		[[Category: Nucleotidyltransferase]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:26:44 2009''~~	+

OCA at 07:26, 18 February 2009

OCA — Wed, 18 Feb 2009 07:26:47 GMT

←Older revision		Revision as of 07:26, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1JV3 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA].	+	1JV3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV3 OCA].

	==Reference==		==Reference==
-	Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture., Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y, EMBO J. 2001 Nov 15;20(22):6191-202. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11707391 11707391]~~	+	<ref group="xtra">PMID:11707391</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Bourne, Y.]]		[[Category: Bourne, Y.]]
	[[Category: Peneff, C.]]		[[Category: Peneff, C.]]
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	[[Category: Nucleotidyltransferase]]		[[Category: Nucleotidyltransferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 20~~:57:~~12 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:26:44 2009''

OCA at 17:57, 1 July 2008

OCA — Tue, 01 Jul 2008 17:57:13 GMT

←Older revision		Revision as of 17:57, 1 July 2008
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-	[[Image:1jv3.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1jv3.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1jv3\| PDB=1jv3 \| SCENE= }}		{{STRUCTURE_1jv3\| PDB=1jv3 \| SCENE= }}

-	~~'''~~CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC~~'''~~	+	===CRYSTAL STRUCTURE OF HUMAN AGX1 COMPLEXED WITH UDPGALNAC===


-	~~==Overview==~~	+	<!--
-	~~The recently published human genome with its relatively modest number of genes has highlighted the importance of post~~-~~transcriptional and post~~-~~translational modifications, such as alternative splicing or glycosylation, in generating the complexities of human biology.~~ The ~~human UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylases AGX1 and AGX2~~, ~~which differ in sequence by an alternatively spliced 17 residue peptide~~, ~~are key enzymes synthesizing UDPGlcNAc, an essential precursor for protein glycosylation. To better understand~~ the ~~catalytic mechanism of these enzymes and~~ the ~~role of the alternatively spliced segment, we have solved the crystal structures of AGX1 and AGX2 in complexes with UDPGlcNAc~~ (at 1.~~9 and 2~~.~~4 A resolution, respectively~~) ~~and UDPGalNAc (at 2.2 and 2.3 A resolution~~, ~~respectively)~~. ~~Comparison with known structures classifies AGX1 and AGX2 as two new members of the SpsA~~-GnT I Core superfamily and, together with mutagenesis analysis, helps identify residues critical for catalysis. Most importantly, our combined structural and biochemical data provide evidence for a change in the oligomeric assembly accompanied by a significant modification of the active site architecture, a result suggesting that the two isoforms generated by alternative splicing may have distinct catalytic properties.	+	The line below this paragraph, {{ABSTRACT_PUBMED_11707391}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11707391 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11707391}}

	==About this Structure==		==About this Structure==
Line 26:		Line 30:
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]
	[[Category: Nucleotidyltransferase]]		[[Category: Nucleotidyltransferase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 21~~:57:38 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:57:12 2008''