1jvr - Revision history

OCA at 08:39, 22 May 2024

OCA — Wed, 22 May 2024 08:39:19 GMT

←Older revision		Revision as of 08:39, 22 May 2024
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvr ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The matrix protein performs similar roles in all retroviruses, initially directing membrane localization of the assembling viral particle and subsequently forming a stable structural shell associated with the inner surface of the mature viral membrane. Although conserved structural elements are likely to perform these functions in all retroviral matrix proteins, invariant motifs are not evident at the primary sequence level and three-dimensional structures have been available for only the primate lentiviral matrix proteins. We have therefore used NMR spectroscopy to determine the structure of the matrix protein from human T-cell leukemia virus type II (HTLV-II), a member of the human oncovirus subclass of retroviruses. A total of 577 distance restraints were used to build 20 refined models that superimpose with an rmsd of 0.71 A for the backbone atoms of the structured regions. The globular HTLV-II matrix structure is composed of four alpha-helices and a 3(10) helix. Exposed basic residues near the C terminus of helix II form a putative membrane binding surface which could act in concert with the N-terminal myristoyl group to anchor the protein on the viral membrane surface. Clear structural similarities between the HTLV-II and HIV-1 matrix proteins suggest that the topology and exposed cationic membrane binding surface are likely to be conserved features of retroviral matrix proteins.
		+
		+	Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses.,Christensen AM, Massiah MA, Turner BG, Sundquist WI, Summers MF J Mol Biol. 1996 Dec 20;264(5):1117-31. PMID:9000634<ref>PMID:9000634</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1jvr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:55, 3 April 2024

OCA — Wed, 03 Apr 2024 07:55:28 GMT

←Older revision		Revision as of 07:55, 3 April 2024
Line 1:		Line 1:

	==STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES==		==STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES==
-	<StructureSection load='1jvr' size='340' side='right'caption='[[1jvr~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1jvr' size='340' side='right'caption='[[1jvr]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Htlv~~-~~2 Htlv~~-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JVR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-lymphotropic_virus_2 Human T-lymphotropic virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [https://pdbe.org/1jvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [https://www.ebi.ac.uk/pdbsum/1jvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvr ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [https://pdbe.org/1jvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [https://www.ebi.ac.uk/pdbsum/1jvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~GAG_HTLV2 GAG_HTLV2~~]~~] Matrix protein p19~~ targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. ~~Also mediates nuclear localization of the preintegration complex (By similarity).~~ ~~Capsid~~ protein ~~p24 forms~~ the ~~conical~~ core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). ~~Nucleocapsid protein p15~~ is ~~involved~~ in the ~~packaging~~ and ~~encapsidation~~ of ~~two copies~~ of the genome (By similarity).	+	[https://www.uniprot.org/uniprot/POL_HTLV2 POL_HTLV2] The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.[UniProtKB:P03345] Matrix protein.[UniProtKB:P03345] Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.[UniProtKB:P03362] Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.[UniProtKB:P03345] The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (Potential). Cleaves the translation initiation factor eIF4G leading to the inhibition of host cap-dependent translation (By similarity).[UniProtKB:P03362][PROSITE-ProRule:PRU00275] RT is a multifunctional enzyme that converts the viral RNA genome into dsDNA in the cytoplasm, shortly after virus entry into the cell. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3' to 5'-endonucleasic mode. Conversion of viral genomic RNA into dsDNA requires many steps. A tRNA-Pro binds to the primer-binding site (PBS) situated at the 5'-end of the viral RNA. RT uses the 3' end of the tRNA primer to perform a short round of RNA-dependent minus-strand DNA synthesis. The reading proceeds through the U5 region and ends after the repeated (R) region which is present at both ends of viral RNA. The portion of the RNA-DNA heteroduplex is digested by the RNase H, resulting in a ssDNA product attached to the tRNA primer. This ssDNA/tRNA hybridizes with the identical R region situated at the 3' end of viral RNA. This template exchange, known as minus-strand DNA strong stop transfer, can be either intra- or intermolecular. RT uses the 3' end of this newly synthesized short ssDNA to perform the RNA-dependent minus-strand DNA synthesis of the whole template. RNase H digests the RNA template except for a polypurine tract (PPT) situated at the 5' end of the genome. It is not clear if both polymerase and RNase H activities are simultaneous. RNase H probably can proceed both in a polymerase-dependent (RNA cut into small fragments by the same RT performing DNA synthesis) and a polymerase-independent mode (cleavage of remaining RNA fragments by free RTs). Secondly, RT performs DNA-directed plus-strand DNA synthesis using the PPT that has not been removed by RNase H as primer. PPT and tRNA primers are then removed by RNase H. The 3' and 5' ssDNA PBS regions hybridize to form a circular dsDNA intermediate. Strand displacement synthesis by RT to the PBS and PPT ends produces a blunt ended, linear dsDNA copy of the viral genome that includes long terminal repeats (LTRs) at both ends (By similarity). Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.<ref>PMID:8623556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvr ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The matrix protein performs similar roles in all retroviruses, initially directing membrane localization of the assembling viral particle and subsequently forming a stable structural shell associated with the inner surface of the mature viral membrane. Although conserved structural elements are likely to perform these functions in all retroviral matrix proteins, invariant motifs are not evident at the primary sequence level and three-dimensional structures have been available for only the primate lentiviral matrix proteins. We have therefore used NMR spectroscopy to determine the structure of the matrix protein from human T-cell leukemia virus type II (HTLV-II), a member of the human oncovirus subclass of retroviruses. A total of 577 distance restraints were used to build 20 refined models that superimpose with an rmsd of 0.71 A for the backbone atoms of the structured regions. The globular HTLV-II matrix structure is composed of four alpha-helices and a 3(10) helix. Exposed basic residues near the C terminus of helix II form a putative membrane binding surface which could act in concert with the N-terminal myristoyl group to anchor the protein on the viral membrane surface. Clear structural similarities between the HTLV-II and HIV-1 matrix proteins suggest that the topology and exposed cationic membrane binding surface are likely to be conserved features of retroviral matrix proteins.
-
-	Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses.,Christensen AM, Massiah MA, Turner BG, Sundquist WI, Summers MF J Mol Biol. 1996 Dec 20;264(5):1117-31. PMID:9000634<ref>PMID:9000634</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jvr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Htlv~~-2]]	+	[[Category: Human T-lymphotropic virus 2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Christensen~~, A M~~]]	+	[[Category: Christensen AM]]
-	[[Category: Massiah~~, M A~~]]	+	[[Category: Massiah MA]]
-	[[Category: Summers~~, M F~~]]	+	[[Category: Summers MF]]
-	[[Category: Sundquist~~, W I~~]]	+	[[Category: Sundquist WI]]
-	[[Category: Turner~~, B G]]~~	+	[[Category: Turner BG]]
-	~~[[Category: Htlv-ii ma]]~~	+
-	~~[[Category: Htlv-ii matrix protein]]~~	+
-	~~[[Category: Human t-cell leukemia virus type ii matrix protein]]~~	+
-	~~[[Category: Matrix protein]]~~	+
-	~~[[Category: P17]]~~	+
-	~~[[Category: Retroviral matrix protein~~]]	+

OCA at 08:43, 21 April 2021

OCA — Wed, 21 Apr 2021 08:43:37 GMT

←Older revision		Revision as of 08:43, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='1jvr' size='340' side='right'caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1jvr' size='340' side='right'caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JVR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [~~http~~://pdbe.org/1jvr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jvr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvr ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [https://pdbe.org/1jvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [https://www.ebi.ac.uk/pdbsum/1jvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GAG_HTLV2 GAG_HTLV2]] Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome (By similarity).	+	[[https://www.uniprot.org/uniprot/GAG_HTLV2 GAG_HTLV2]] Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:29, 17 July 2019

OCA — Wed, 17 Jul 2019 13:29:51 GMT

←Older revision		Revision as of 13:29, 17 July 2019
Line 1:		Line 1:

	==STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES==		==STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES==
-	<StructureSection load='1jvr' size='340' side='right' caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1jvr' size='340' side='right'caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jvr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jvr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Htlv-2]]		[[Category: Htlv-2]]
		+	[[Category: Large Structures]]
	[[Category: Christensen, A M]]		[[Category: Christensen, A M]]
	[[Category: Massiah, M A]]		[[Category: Massiah, M A]]

OCA at 07:20, 11 October 2017

OCA — Wed, 11 Oct 2017 07:20:05 GMT

←Older revision		Revision as of 07:20, 11 October 2017
Line 1:		Line 1:
		+
	==STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES==		==STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES==
	<StructureSection load='1jvr' size='340' side='right' caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1jvr' size='340' side='right' caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://pdbe.org/1jvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://pdbe.org/1jvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:53, 11 September 2015

OCA — Fri, 11 Sep 2015 10:53:54 GMT

←Older revision		Revision as of 10:53, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jvr' size='340' side='right' caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1jvr' size='340' side='right' caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_t~~-~~lymphotropic_virus_2 Human t~~-~~lymphotropic virus~~ 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://pdbe.org/1jvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jvr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human t~~-~~lymphotropic virus~~ 2]]	+	[[Category: Htlv-2]]
	[[Category: Christensen, A M]]		[[Category: Christensen, A M]]
	[[Category: Massiah, M A]]		[[Category: Massiah, M A]]

OCA at 15:29, 25 December 2014

OCA — Thu, 25 Dec 2014 15:29:20 GMT

←Older revision		Revision as of 15:29, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_2 Human t-lymphotropic virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_2 Human t-lymphotropic virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GAG_HTLV2 GAG_HTLV2]] Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human t-lymphotropic virus 2]]		[[Category: Human t-lymphotropic virus 2]]
-	[[Category: Christensen, A M.]]	+	[[Category: Christensen, A M]]
-	[[Category: Massiah, M A.]]	+	[[Category: Massiah, M A]]
-	[[Category: Summers, M F.]]	+	[[Category: Summers, M F]]
-	[[Category: Sundquist, W I.]]	+	[[Category: Sundquist, W I]]
-	[[Category: Turner, B G.]]	+	[[Category: Turner, B G]]
	[[Category: Htlv-ii ma]]		[[Category: Htlv-ii ma]]
	[[Category: Htlv-ii matrix protein]]		[[Category: Htlv-ii matrix protein]]

OCA at 08:51, 28 September 2014

OCA — Sun, 28 Sep 2014 08:51:58 GMT

←Older revision		Revision as of 08:51, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1jvr.~~png\|left~~\|200px]]	+	==STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES==
		+	<StructureSection load='1jvr' size='340' side='right' caption='[[1jvr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_2 Human t-lymphotropic virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jvr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The matrix protein performs similar roles in all retroviruses, initially directing membrane localization of the assembling viral particle and subsequently forming a stable structural shell associated with the inner surface of the mature viral membrane. Although conserved structural elements are likely to perform these functions in all retroviral matrix proteins, invariant motifs are not evident at the primary sequence level and three-dimensional structures have been available for only the primate lentiviral matrix proteins. We have therefore used NMR spectroscopy to determine the structure of the matrix protein from human T-cell leukemia virus type II (HTLV-II), a member of the human oncovirus subclass of retroviruses. A total of 577 distance restraints were used to build 20 refined models that superimpose with an rmsd of 0.71 A for the backbone atoms of the structured regions. The globular HTLV-II matrix structure is composed of four alpha-helices and a 3(10) helix. Exposed basic residues near the C terminus of helix II form a putative membrane binding surface which could act in concert with the N-terminal myristoyl group to anchor the protein on the viral membrane surface. Clear structural similarities between the HTLV-II and HIV-1 matrix proteins suggest that the topology and exposed cationic membrane binding surface are likely to be conserved features of retroviral matrix proteins.

-	~~{{STRUCTURE_1jvr\| PDB=1jvr \| SCENE= }}~~	+	Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses.,Christensen AM, Massiah MA, Turner BG, Sundquist WI, Summers MF J Mol Biol. 1996 Dec 20;264(5):1117-31. PMID:9000634<ref>PMID:9000634</ref>

-	~~===STRUCTURE OF THE HTLV-II MATRIX PROTEIN~~, ~~NMR, 20 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9000634}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jvr]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_t-lymphotropic_virus_2 Human t-lymphotropic virus 2]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009000634<~~/~~ref~~><~~ref group="xtra">PMID:011173462</ref><references group="xtra"~~/>	+
	[[Category: Human t-lymphotropic virus 2]]		[[Category: Human t-lymphotropic virus 2]]
	[[Category: Christensen, A M.]]		[[Category: Christensen, A M.]]

OCA: Protected "1jvr" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:21:17 GMT

Protected "1jvr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:21, 5 December 2012

OCA at 11:21, 5 December 2012

OCA — Wed, 05 Dec 2012 11:21:13 GMT

←Older revision		Revision as of 11:21, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jvr.png\|left\|200px]]		[[Image:1jvr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jvr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jvr\| PDB=1jvr \| SCENE= }}		{{STRUCTURE_1jvr\| PDB=1jvr \| SCENE= }}

	===STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES===		===STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9000634}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9000634 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9000634}}		{{ABSTRACT_PUBMED_9000634}}

	==About this Structure==		==About this Structure==
-	~~1JVR~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_t-~~cell_leukemia_virus_type_ii~~ Human t-~~cell leukemia~~ virus ~~type ii~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA].	+	[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_2 Human t-lymphotropic virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9000634~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009000634</ref><ref group="xtra">PMID:011173462</ref><references group="xtra"/>
-	[[Category: Human t-~~cell leukemia~~ virus ~~type ii~~]]	+	[[Category: Human t-lymphotropic virus 2]]
	[[Category: Christensen, A M.]]		[[Category: Christensen, A M.]]
	[[Category: Massiah, M A.]]		[[Category: Massiah, M A.]]
Line 33:		Line 21:
	[[Category: Htlv-ii matrix protein]]		[[Category: Htlv-ii matrix protein]]
	[[Category: Human t-cell leukemia virus type ii matrix protein]]		[[Category: Human t-cell leukemia virus type ii matrix protein]]
		+	[[Category: Matrix protein]]
	[[Category: P17]]		[[Category: P17]]
	[[Category: Retroviral matrix protein]]		[[Category: Retroviral matrix protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:22:31 2009''