1jx5 - Revision history

OCA at 06:46, 11 August 2021

OCA — Wed, 11 Aug 2021 06:46:36 GMT

←Older revision		Revision as of 06:46, 11 August 2021
Line 4:		Line 4:
	<StructureSection load='1jx5' size='340' side='right'caption='[[1jx5]]' scene=''>		<StructureSection load='1jx5' size='340' side='right'caption='[[1jx5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JX5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jx5 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1jx5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx5 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jx5 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1jx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:08, 6 November 2019

OCA — Wed, 06 Nov 2019 09:08:08 GMT

←Older revision		Revision as of 09:08, 6 November 2019
Line 2:		Line 2:

	==THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB==		==THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB==
-	<StructureSection load='1jx5' size='340' side='right' caption='[[1jx5]]' scene=''>	+	<StructureSection load='1jx5' size='340' side='right'caption='[[1jx5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX5 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX5 FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Kamata, T]]		[[Category: Kamata, T]]
	[[Category: Springer, T A]]		[[Category: Springer, T A]]
	[[Category: Takada, Y]]		[[Category: Takada, Y]]
	[[Category: Tieu, K K]]		[[Category: Tieu, K K]]

OCA at 08:45, 17 January 2018

OCA — Wed, 17 Jan 2018 08:45:11 GMT

←Older revision		Revision as of 08:45, 17 January 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX5 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx5 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jx5 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx5 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jx5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:08, 11 February 2016

OCA — Thu, 11 Feb 2016 09:08:02 GMT

←Older revision		Revision as of 09:08, 11 February 2016
Line 1:		Line 1:
		+	{{Theoretical_model}}
		+
	==THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB==		==THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB==
	<StructureSection load='1jx5' size='340' side='right' caption='[[1jx5]]' scene=''>		<StructureSection load='1jx5' size='340' side='right' caption='[[1jx5]]' scene=''>
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Kamata, T]]		[[Category: Kamata, T]]
	[[Category: Springer, T A]]		[[Category: Springer, T A]]
	[[Category: Takada, Y]]		[[Category: Takada, Y]]
	[[Category: Tieu, K K]]		[[Category: Tieu, K K]]

OCA at 22:41, 9 September 2015

OCA — Wed, 09 Sep 2015 22:41:17 GMT

←Older revision		Revision as of 22:41, 9 September 2015
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jx5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:42, 18 December 2014

OCA — Thu, 18 Dec 2014 11:42:18 GMT

←Older revision		Revision as of 11:42, 18 December 2014
Line 1:		Line 1:
-	~~{{Theoretical_model}}~~	+	==THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB==
		+	<StructureSection load='1jx5' size='340' side='right' caption='[[1jx5]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX5 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx5 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1jx5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several distinct regions of the integrin alpha(IIb) subunit have been implicated in ligand binding. To localize the ligand binding sites in alpha(IIb), we swapped all 27 predicted loops with the corresponding sequences of alpha(4) or alpha(5). 19 of the 27 swapping mutations had no effect on binding to both fibrinogen and ligand-mimetic antibodies (e.g. LJ-CP3), suggesting that these regions do not contain major ligand binding sites. In contrast, swapping the remaining 8 predicted loops completely blocked ligand binding. Ala scanning mutagenesis of these critical predicted loops identified more than 30 discontinuous residues in repeats 2-4 and at the boundary between repeats 4 and 5 as critical for ligand binding. Interestingly, these residues are clustered in the predicted beta-propeller model, consistent with this model. Most of the critical residues are located at the edge of the upper face of the propeller, and several critical residues are located on the side of the propeller domain. None of the predicted loops in repeats 1, 6, and 7, and none of the four putative Ca(2+)-binding predicted loops on the lower surface of the beta-propeller were important for ligand binding. The results map an important ligand binding interface at the edge of the top and on the side of the beta-propeller toroid, centering on repeat 3.

-	~~{{STRUCTURE_1jx5\| PDB=1jx5 \| SCENE= }}~~	+	Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model.,Kamata T, Tieu KK, Irie A, Springer TA, Takada Y J Biol Chem. 2001 Nov 23;276(47):44275-83. Epub 2001 Sep 13. PMID:11557768<ref>PMID:11557768</ref>
-	~~===THEORETICAL MODEL OF THE BETA~~-~~PROPELLER DOMAIN OF INTEGRIN ALPHAIIB===~~	+
-	~~{{ABSTRACT_PUBMED_11557768}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:011557768</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Kamata, T]]		[[Category: Kamata, T]]
	[[Category: Springer, T A]]		[[Category: Springer, T A]]
	[[Category: Takada, Y]]		[[Category: Takada, Y]]
	[[Category: Tieu, K K]]		[[Category: Tieu, K K]]

OCA at 12:13, 24 March 2013

OCA — Sun, 24 Mar 2013 12:13:29 GMT

←Older revision		Revision as of 12:13, 24 March 2013
Line 1:		Line 1:
	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:1jx5.png\|left\|200px]]

	{{STRUCTURE_1jx5\| PDB=1jx5 \| SCENE= }}		{{STRUCTURE_1jx5\| PDB=1jx5 \| SCENE= }}
-
	===THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB===		===THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB===
-
	{{ABSTRACT_PUBMED_11557768}}		{{ABSTRACT_PUBMED_11557768}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011557768</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011557768</ref><references group="xtra"/><references/>
	[[Category: Kamata, T]]		[[Category: Kamata, T]]
	[[Category: Springer, T A]]		[[Category: Springer, T A]]
	[[Category: Takada, Y]]		[[Category: Takada, Y]]
	[[Category: Tieu, K K]]		[[Category: Tieu, K K]]

OCA: Protected "1jx5" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 08:48:32 GMT

Protected "1jx5" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 21 October 2012

OCA at 08:48, 21 October 2012

OCA — Sun, 21 Oct 2012 08:48:26 GMT

←Older revision		Revision as of 08:48, 21 October 2012
Line 1:		Line 1:
	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1jx5.png\|left\|200px]]		[[Image:1jx5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jx5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jx5\| PDB=1jx5 \| SCENE= }}		{{STRUCTURE_1jx5\| PDB=1jx5 \| SCENE= }}

	===THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB===		===THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11557768}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11557768 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11557768}}		{{ABSTRACT_PUBMED_11557768}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11557768~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011557768</ref><references group="xtra"/>
	[[Category: Kamata, T]]		[[Category: Kamata, T]]
	[[Category: Springer, T A]]		[[Category: Springer, T A]]
	[[Category: Takada, Y]]		[[Category: Takada, Y]]
	[[Category: Tieu, K K]]		[[Category: Tieu, K K]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 06:59:20 2010''

OCA at 03:59, 8 April 2010

OCA — Thu, 08 Apr 2010 03:59:20 GMT

←Older revision		Revision as of 03:59, 8 April 2010
Line 1:		Line 1:
-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1jx5.png\|left\|200px]]

-	The ~~entry 1JX5~~ is ~~a Theoretical Model titled 'Theoretical Model of~~ the ~~beta-Propeller Domain of Integrin alphaIIb'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1jx5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1jx5\| PDB=1jx5 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===THEORETICAL MODEL OF THE BETA-PROPELLER DOMAIN OF INTEGRIN ALPHAIIB===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:50:~~27 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_11557768}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11557768 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11557768}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:11557768</ref><references group="xtra"/>
		+	[[Category: Kamata, T]]
		+	[[Category: Springer, T A]]
		+	[[Category: Takada, Y]]
		+	[[Category: Tieu, K K]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 06:59:20 2010''