1jx6 - Revision history

OCA at 07:42, 7 February 2024

OCA — Wed, 07 Feb 2024 07:42:39 GMT

←Older revision		Revision as of 07:42, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='1jx6' size='340' side='right'caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jx6' size='340' side='right'caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"achromobacter_harveyi"_johnson_and_shunk_1936 "achromobacter~~ harveyi~~" johnson and shunk 1936~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 "Achromobacter harveyi" Johnson and Shunk 1936])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [~~http~~://pdbe.org/1jx6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jx6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [https://pdbe.org/1jx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [https://www.ebi.ac.uk/pdbsum/1jx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LUXP_VIBHA LUXP_VIBHA]] Binds to the signaling molecule autoinducer 2 (AI-2), a furanosyl borate diester, (3a-methyl-5,6-dihydrofuro-[2,3d][1,3,2]dioxaborole-2,2,6,6a-tetraol). This complex then interacts with the LuxQ sensor protein.	+	[https://www.uniprot.org/uniprot/LUXP_VIBHA LUXP_VIBHA] Binds to the signaling molecule autoinducer 2 (AI-2), a furanosyl borate diester, (3a-methyl-5,6-dihydrofuro-[2,3d][1,3,2]dioxaborole-2,2,6,6a-tetraol). This complex then interacts with the LuxQ sensor protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jx6 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jx6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cell-cell communication in bacteria is accomplished through the exchange of extracellular signalling molecules called autoinducers. This process, termed quorum sensing, allows bacterial populations to coordinate gene expression. Community cooperation probably enhances the effectiveness of processes such as bioluminescence, virulence factor expression, antibiotic production and biofilm development. Unlike other autoinducers, which are specific to a particular species of bacteria, a recently discovered autoinducer (AI-2) is produced by a large number of bacterial species. AI-2 has been proposed to serve as a 'universal' signal for inter-species communication. The chemical identity of AI-2 has, however, proved elusive. Here we present the crystal structure of an AI-2 sensor protein, LuxP, in a complex with autoinducer. The bound ligand is a furanosyl borate diester that bears no resemblance to previously characterized autoinducers. Our findings suggest that addition of naturally occurring borate to an AI-2 precursor generates active AI-2. Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.
-
-	Structural identification of a bacterial quorum-sensing signal containing boron.,Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM Nature. 2002 Jan 31;415(6871):545-9. PMID:11823863<ref>PMID:11823863</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jx6" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Achromobacter harveyi johnson and shunk 1936]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~BassleR, B L~~]]	+	[[Category: Vibrio harveyi]]
-	[[Category: ~~Chen, X~~]]	+	[[Category: BassleR BL]]
-	[[Category: ~~Dorsselaer, A Van~~]]	+	[[Category: Chen X]]
-	[[Category: Hughson~~, F M~~]]	+	[[Category: Hughson FM]]
-	[[Category: Pelczer, I]]	+	[[Category: Pelczer I]]
-	[[Category: Potier, N]]	+	[[Category: Potier N]]
-	[[Category: Schauder, S]]	+	[[Category: Schauder S]]
-	[[Category: ~~Protein-ligand complex]]~~	+	[[Category: Van Dorsselaer A]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:37, 25 November 2020

OCA — Wed, 25 Nov 2020 07:37:14 GMT

←Older revision		Revision as of 07:37, 25 November 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2==		==CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2==
-	<StructureSection load='1jx6' size='340' side='right' caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1jx6' size='340' side='right'caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_harveyi"_johnson_and_shunk_1936 "achromobacter harveyi" johnson and shunk 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_harveyi"_johnson_and_shunk_1936 "achromobacter harveyi" johnson and shunk 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 "Achromobacter harveyi" Johnson and Shunk 1936])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 "Achromobacter harveyi" Johnson and Shunk 1936])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://pdbe.org/1jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://pdbe.org/1jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Achromobacter harveyi johnson and shunk 1936]]		[[Category: Achromobacter harveyi johnson and shunk 1936]]
		+	[[Category: Large Structures]]
	[[Category: BassleR, B L]]		[[Category: BassleR, B L]]
	[[Category: Chen, X]]		[[Category: Chen, X]]

OCA at 08:56, 17 January 2018

OCA — Wed, 17 Jan 2018 08:56:52 GMT

←Older revision		Revision as of 08:56, 17 January 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2==		==CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2==
	<StructureSection load='1jx6' size='340' side='right' caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jx6' size='340' side='right' caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 "Achromobacter harveyi" Johnson and Shunk 1936])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 "Achromobacter harveyi" Johnson and Shunk 1936])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://pdbe.org/1jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://pdbe.org/1jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jx6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jx6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:27, 8 February 2016

OCA — Mon, 08 Feb 2016 18:27:21 GMT

←Older revision		Revision as of 18:27, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jx6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:14, 10 September 2015

OCA — Thu, 10 Sep 2015 14:14:13 GMT

←Older revision		Revision as of 14:14, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1jx6' size='340' side='right' caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jx6' size='340' side='right' caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_harveyi Vibrio~~ harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_harveyi"_johnson_and_shunk_1936 "achromobacter harveyi" johnson and shunk 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 ~~Vibrio~~ harveyi])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 "Achromobacter harveyi" Johnson and Shunk 1936])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://pdbe.org/1jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jx6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ harveyi]]	+	[[Category: Achromobacter harveyi johnson and shunk 1936]]
	[[Category: BassleR, B L]]		[[Category: BassleR, B L]]
	[[Category: Chen, X]]		[[Category: Chen, X]]

OCA at 01:17, 25 December 2014

OCA — Thu, 25 Dec 2014 01:17:54 GMT

←Older revision		Revision as of 01:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 Vibrio harveyi])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 Vibrio harveyi])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LUXP_VIBHA LUXP_VIBHA]] Binds to the signaling molecule autoinducer 2 (AI-2), a furanosyl borate diester, (3a-methyl-5,6-dihydrofuro-[2,3d][1,3,2]dioxaborole-2,2,6,6a-tetraol). This complex then interacts with the LuxQ sensor protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio harveyi]]		[[Category: Vibrio harveyi]]
-	[[Category: BassleR, B L.]]	+	[[Category: BassleR, B L]]
-	[[Category: Chen, X.]]	+	[[Category: Chen, X]]
-	[[Category: Dorsselaer, A Van.]]	+	[[Category: Dorsselaer, A Van]]
-	[[Category: Hughson, F M.]]	+	[[Category: Hughson, F M]]
-	[[Category: Pelczer, I.]]	+	[[Category: Pelczer, I]]
-	[[Category: Potier, N.]]	+	[[Category: Potier, N]]
-	[[Category: Schauder, S.]]	+	[[Category: Schauder, S]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 12:39, 28 September 2014

OCA — Sun, 28 Sep 2014 12:39:33 GMT

←Older revision		Revision as of 12:39, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jx6.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2==
		+	<StructureSection load='1jx6' size='340' side='right' caption='[[1jx6]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JX6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AI2:3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL'>AI2</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LUXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 Vibrio harveyi])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jx6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jx6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell-cell communication in bacteria is accomplished through the exchange of extracellular signalling molecules called autoinducers. This process, termed quorum sensing, allows bacterial populations to coordinate gene expression. Community cooperation probably enhances the effectiveness of processes such as bioluminescence, virulence factor expression, antibiotic production and biofilm development. Unlike other autoinducers, which are specific to a particular species of bacteria, a recently discovered autoinducer (AI-2) is produced by a large number of bacterial species. AI-2 has been proposed to serve as a 'universal' signal for inter-species communication. The chemical identity of AI-2 has, however, proved elusive. Here we present the crystal structure of an AI-2 sensor protein, LuxP, in a complex with autoinducer. The bound ligand is a furanosyl borate diester that bears no resemblance to previously characterized autoinducers. Our findings suggest that addition of naturally occurring borate to an AI-2 precursor generates active AI-2. Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.

-	~~{{STRUCTURE_1jx6\| PDB=1jx6 \| SCENE= }}~~	+	Structural identification of a bacterial quorum-sensing signal containing boron.,Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM Nature. 2002 Jan 31;415(6871):545-9. PMID:11823863<ref>PMID:11823863</ref>

-	~~===CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11823863}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jx6]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Vibrio_harveyi Vibrio harveyi]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011823863<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Vibrio harveyi]]		[[Category: Vibrio harveyi]]
	[[Category: BassleR, B L.]]		[[Category: BassleR, B L.]]

OCA: Protected "1jx6" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:35:52 GMT

Protected "1jx6" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:35, 5 December 2012

OCA at 11:35, 5 December 2012

OCA — Wed, 05 Dec 2012 11:35:49 GMT

←Older revision		Revision as of 11:35, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jx6.png\|left\|200px]]		[[Image:1jx6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jx6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jx6\| PDB=1jx6 \| SCENE= }}		{{STRUCTURE_1jx6\| PDB=1jx6 \| SCENE= }}

	===CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2===		===CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11823863}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11823863 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11823863}}		{{ABSTRACT_PUBMED_11823863}}

	==About this Structure==		==About this Structure==
-	~~1JX6~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA].	+	[[1jx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11823863~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011823863</ref><references group="xtra"/>
	[[Category: Vibrio harveyi]]		[[Category: Vibrio harveyi]]
	[[Category: BassleR, B L.]]		[[Category: BassleR, B L.]]
Line 33:		Line 21:
	[[Category: Schauder, S.]]		[[Category: Schauder, S.]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 01:28:12 2009''~~	+

OCA at 23:28, 16 February 2009

OCA — Mon, 16 Feb 2009 23:28:15 GMT

←Older revision		Revision as of 23:28, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1JX6 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA].	+	1JX6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX6 OCA].

	==Reference==		==Reference==
-	Structural identification of a bacterial quorum-sensing signal containing boron., Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM, Nature. 2002 Jan 31;415(6871):545-9. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11823863 11823863]~~	+	<ref group="xtra">PMID:11823863</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Vibrio harveyi]]		[[Category: Vibrio harveyi]]
	[[Category: BassleR, B L.]]		[[Category: BassleR, B L.]]
Line 35:		Line 34:
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 05~~:41:~~52 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:28:12 2009''