1jxq - Revision history

OCA at 08:47, 16 August 2023

OCA — Wed, 16 Aug 2023 08:47:45 GMT

←Older revision		Revision as of 08:47, 16 August 2023
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	<StructureSection load='1jxq' size='340' side='right'caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1jxq' size='340' side='right'caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CF0:FLUOROMETHANE'>CF0</scene~~>, ~~<scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[3ygs\|3ygs]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [https://pdbe.org/1jxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [https://www.ebi.ac.uk/pdbsum/1jxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [https://pdbe.org/1jxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [https://www.ebi.ac.uk/pdbsum/1jxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liddington~~, R C~~]]	+	[[Category: Liddington RC]]
-	[[Category: Renatus, M]]	+	[[Category: Renatus M]]
-	[[Category: Salvesen~~, G S~~]]	+	[[Category: Salvesen GS]]
-	[[Category: Scott~~, F L~~]]	+	[[Category: Scott FL]]
-	[[Category: Stennicke~~, H R]]~~	+	[[Category: Stennicke HR]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 08:43, 21 April 2021

OCA — Wed, 21 Apr 2021 08:43:58 GMT

←Older revision		Revision as of 08:43, 21 April 2021
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	<StructureSection load='1jxq' size='340' side='right'caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1jxq' size='340' side='right'caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ygs\|3ygs]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [~~http~~://pdbe.org/1jxq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jxq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [https://pdbe.org/1jxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [https://www.ebi.ac.uk/pdbsum/1jxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Caspase 3D structures\|Caspase 3D structures]]		*[[Caspase 3D structures\|Caspase 3D structures]]
-	*[[Molecular Playground/Caspase-9 Regulation\|Molecular Playground/Caspase-9 Regulation]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:05, 17 July 2019

OCA — Wed, 17 Jul 2019 13:05:17 GMT

←Older revision		Revision as of 13:05, 17 July 2019
Line 1:		Line 1:

	==Structure of cleaved, CARD domain deleted Caspase-9==		==Structure of cleaved, CARD domain deleted Caspase-9==
-	<StructureSection load='1jxq' size='340' side='right' caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1jxq' size='340' side='right'caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:

	==See Also==		==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
	*[[Molecular Playground/Caspase-9 Regulation\|Molecular Playground/Caspase-9 Regulation]]		*[[Molecular Playground/Caspase-9 Regulation\|Molecular Playground/Caspase-9 Regulation]]
	== References ==		== References ==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Liddington, R C]]		[[Category: Liddington, R C]]
	[[Category: Renatus, M]]		[[Category: Renatus, M]]

OCA at 07:20, 11 October 2017

OCA — Wed, 11 Oct 2017 07:20:50 GMT

←Older revision		Revision as of 07:20, 11 October 2017
Line 1:		Line 1:
		+
	==Structure of cleaved, CARD domain deleted Caspase-9==		==Structure of cleaved, CARD domain deleted Caspase-9==
	<StructureSection load='1jxq' size='340' side='right' caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1jxq' size='340' side='right' caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [http://pdbe.org/1jxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [http://www.ebi.ac.uk/pdbsum/1jxq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [http://pdbe.org/1jxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [http://www.ebi.ac.uk/pdbsum/1jxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[Caspase\|Caspase]]
	*[[Molecular Playground/Caspase-9 Regulation\|Molecular Playground/Caspase-9 Regulation]]		*[[Molecular Playground/Caspase-9 Regulation\|Molecular Playground/Caspase-9 Regulation]]
	== References ==		== References ==

OCA at 09:05, 11 September 2015

OCA — Fri, 11 Sep 2015 09:05:59 GMT

←Older revision		Revision as of 09:05, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jxq' size='340' side='right' caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1jxq' size='340' side='right' caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [http://www.ebi.ac.uk/pdbsum/1jxq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [http://pdbe.org/1jxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [http://www.ebi.ac.uk/pdbsum/1jxq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jxq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Liddington, R C]]		[[Category: Liddington, R C]]
	[[Category: Renatus, M]]		[[Category: Renatus, M]]

OCA at 12:11, 2 January 2015

OCA — Fri, 02 Jan 2015 12:11:03 GMT

←Older revision		Revision as of 12:11, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [http://www.ebi.ac.uk/pdbsum/1jxq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [http://www.ebi.ac.uk/pdbsum/1jxq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Liddington, R C.]]	+	[[Category: Liddington, R C]]
-	[[Category: Renatus, M.]]	+	[[Category: Renatus, M]]
-	[[Category: Salvesen, G S.]]	+	[[Category: Salvesen, G S]]
-	[[Category: Scott, F L.]]	+	[[Category: Scott, F L]]
-	[[Category: Stennicke, H R.]]	+	[[Category: Stennicke, H R]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 16:51, 29 September 2014

OCA — Mon, 29 Sep 2014 16:51:38 GMT

←Older revision		Revision as of 16:51, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1jxq\| PDB=1jxq \| SCENE= }}~~	+	==Structure of cleaved, CARD domain deleted Caspase-9==
-	===Structure of cleaved, CARD domain deleted Caspase-9===	+	<StructureSection load='1jxq' size='340' side='right' caption='[[1jxq]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_11734640}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JXQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ygs\|3ygs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jxq RCSB], [http://www.ebi.ac.uk/pdbsum/1jxq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal physiological concentration, caspase 9 is primarily an inactive monomer (zymogen), and that activity is associated with a dimeric species. At the high concentrations used for crystal formation, caspase 9 is dimeric, and the structure reveals two very different active-site conformations within each dimer. One site closely resembles the catalytically competent sites of other caspases, whereas in the second, expulsion of the "activation loop" disrupts the catalytic machinery. We propose that the inactive domain resembles monomeric caspase 9. Activation is induced by dimerization, with interactions at the dimer interface promoting reorientation of the activation loop. These observations support a model in which recruitment by Apaf-1 creates high local concentrations of caspase 9 to provide a pathway for dimer-induced activation.

-	~~==About this Structure==~~	+	Dimer formation drives the activation of the cell death protease caspase 9.,Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14250-5. PMID:11734640<ref>PMID:11734640</ref>
-	~~[[1jxq]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1JXQ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
	*[[Molecular Playground/Caspase-9 Regulation\|Molecular Playground/Caspase-9 Regulation]]		*[[Molecular Playground/Caspase-9 Regulation\|Molecular Playground/Caspase-9 Regulation]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011734640<~~/~~ref~~><~~ref group="xtra">PMID:020844150</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Liddington, R C.]]		[[Category: Liddington, R C.]]

OCA at 10:18, 11 March 2013

OCA — Mon, 11 Mar 2013 10:18:39 GMT

←Older revision		Revision as of 10:18, 11 March 2013
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-	[[Image:1jxq.png\|left\|200px]]
-
	{{STRUCTURE_1jxq\| PDB=1jxq \| SCENE= }}		{{STRUCTURE_1jxq\| PDB=1jxq \| SCENE= }}
-
	===Structure of cleaved, CARD domain deleted Caspase-9===		===Structure of cleaved, CARD domain deleted Caspase-9===
-
	{{ABSTRACT_PUBMED_11734640}}		{{ABSTRACT_PUBMED_11734640}}

OCA at 17:42, 20 October 2012

OCA — Sat, 20 Oct 2012 17:42:27 GMT

←Older revision		Revision as of 17:42, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1jxq]] is a 6 chain structure ~~of [[Caspase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA].	+	[[1jxq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXQ OCA].

	==See Also==		==See Also==

OCA: Protected "1jxq" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 01:45:57 GMT

Protected "1jxq" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:45, 27 July 2012