1jy4 - Revision history

OCA at 18:44, 29 November 2023

OCA — Wed, 29 Nov 2023 18:44:47 GMT

←Older revision		Revision as of 18:44, 29 November 2023
Line 1:		Line 1:

	==B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND==		==B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND==
-	<StructureSection load='1jy4' size='340' side='right'caption='[[1jy4~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1jy4' size='340' side='right'caption='[[1jy4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=DPR:D-PROLINE'>DPR</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1jy6\|1jy6]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [https://pdbe.org/1jy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [https://www.ebi.ac.uk/pdbsum/1jy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jy4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [https://pdbe.org/1jy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [https://www.ebi.ac.uk/pdbsum/1jy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jy4 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Balaram, P]]	+	[[Category: Balaram P]]
-	[[Category: Gowda~~, G A.Nagana~~]]	+	[[Category: Nagana Gowda GA]]
-	[[Category: Venkatraman, J]]	+	[[Category: Venkatraman J]]
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: De novo protein design]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Eight-stranded beta-sheet~~]]	+

OCA at 08:44, 21 April 2021

OCA — Wed, 21 Apr 2021 08:44:02 GMT

←Older revision		Revision as of 08:44, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='1jy4' size='340' side='right'caption='[[1jy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1jy4' size='340' side='right'caption='[[1jy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jy6\|1jy6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [~~http~~://pdbe.org/1jy4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jy4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jy4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [https://pdbe.org/1jy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [https://www.ebi.ac.uk/pdbsum/1jy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jy4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:38, 17 July 2019

OCA — Wed, 17 Jul 2019 13:38:40 GMT

←Older revision		Revision as of 13:38, 17 July 2019
Line 1:		Line 1:

	==B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND==		==B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND==
-	<StructureSection load='1jy4' size='340' side='right' caption='[[1jy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1jy4' size='340' side='right'caption='[[1jy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Balaram, P]]		[[Category: Balaram, P]]
	[[Category: Gowda, G A.Nagana]]		[[Category: Gowda, G A.Nagana]]

OCA at 07:27, 11 October 2017

OCA — Wed, 11 Oct 2017 07:27:33 GMT

←Older revision		Revision as of 07:27, 11 October 2017
Line 1:		Line 1:
		+
	==B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND==		==B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND==
	<StructureSection load='1jy4' size='340' side='right' caption='[[1jy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1jy4' size='340' side='right' caption='[[1jy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [http://pdbe.org/1jy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1jy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [http://pdbe.org/1jy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1jy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jy4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:42, 10 September 2015

OCA — Thu, 10 Sep 2015 16:42:14 GMT

←Older revision		Revision as of 16:42, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1jy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [http://pdbe.org/1jy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1jy4 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jy4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:20, 2 January 2015

OCA — Fri, 02 Jan 2015 12:20:26 GMT

←Older revision		Revision as of 12:20, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1jy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1jy4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Balaram, P.]]	+	[[Category: Balaram, P]]
-	[[Category: Gowda, G A.Nagana.]]	+	[[Category: Gowda, G A.Nagana]]
-	[[Category: Venkatraman, J.]]	+	[[Category: Venkatraman, J]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: De novo protein design]]		[[Category: De novo protein design]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Eight-stranded beta-sheet]]		[[Category: Eight-stranded beta-sheet]]

OCA at 05:49, 8 June 2014

OCA — Sun, 08 Jun 2014 05:49:56 GMT

←Older revision		Revision as of 05:49, 8 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1jy4.~~png~~\|~~left~~\|~~200px~~]]	+	==B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND==
		+	<StructureSection load='1jy4' size='340' side='right' caption='[[1jy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JY4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jy6\|1jy6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1jy4 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The design and characterization of an open eight-stranded beta-sheet in a synthetic, 2-fold symmetric 70-residue peptide is described. The design strategy involves the generation of a 35-residue four-stranded beta-sheet peptide in which successive hairpins are nucleated by appropriately positioned (D)Pro-Xxx sequences. Oxidative dimerization using a single Cys residue positioned at the center of the C-terminal strand results in a disulfide-bridged eight-stranded structure. Nuclear Overhauser effects firmly establish an eight-stranded beta-sheet in methanol. In water, the outer strands are frayed, but a well-defined four-stranded beta-sheet stabilized by a disulfide bridge and a hydrophobic cluster is determined from NMR data. Comparison of the precursor peptide with the disulfide-bridged dimer reveals considerable enhancement of beta-sheet content in the latter, suggesting that the disulfide cross-link is an effective strategy for the stabilization of beta-sheets.

-	~~{{STRUCTURE_1jy4\| PDB=1jy4 \| SCENE= }}~~	+	Design and construction of an open multistranded beta-sheet polypeptide stabilized by a disulfide bridge.,Venkatraman J, Nagana Gowda GA, Balaram P J Am Chem Soc. 2002 May 8;124(18):4987-94. PMID:11982362<ref>PMID:11982362</ref>

-	~~===B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11982362}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jy4]] is~~ a ~~2 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1JY4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011982362<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Balaram, P.]]		[[Category: Balaram, P.]]
	[[Category: Gowda, G A.Nagana.]]		[[Category: Gowda, G A.Nagana.]]

OCA: Protected "1jy4" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 16:43:00 GMT

Protected "1jy4" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:43, 14 August 2012

OCA at 16:42, 14 August 2012

OCA — Tue, 14 Aug 2012 16:42:59 GMT

←Older revision		Revision as of 16:42, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jy4.png\|left\|200px]]		[[Image:1jy4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jy4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jy4\| PDB=1jy4 \| SCENE= }}		{{STRUCTURE_1jy4\| PDB=1jy4 \| SCENE= }}

	===B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND===		===B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11982362}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11982362 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11982362}}		{{ABSTRACT_PUBMED_11982362}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA].	+	[[1jy4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA].

	==Reference==		==Reference==
-	~~Design and construction of an open multistranded beta-sheet polypeptide stabilized by a disulfide bridge., Venkatraman J, Nagana Gowda GA, Balaram P, J Am Chem Soc. 2002 May 8;124(18):4987-94.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~11982362 11982362]~~	+	<ref group="xtra">PMID:011982362</ref><references group="xtra"/>
	[[Category: Balaram, P.]]		[[Category: Balaram, P.]]
	[[Category: Gowda, G A.Nagana.]]		[[Category: Gowda, G A.Nagana.]]
	[[Category: Venkatraman, J.]]		[[Category: Venkatraman, J.]]
		+	[[Category: De novo protein]]
	[[Category: De novo protein design]]		[[Category: De novo protein design]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Eight-stranded beta-sheet]]		[[Category: Eight-stranded beta-sheet]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:36 2008''

OCA at 05:07, 28 July 2008

OCA — Mon, 28 Jul 2008 05:07:42 GMT

←Older revision		Revision as of 05:07, 28 July 2008
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-	[[Image:1jy4.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1jy4.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1jy4\| PDB=1jy4 \| SCENE= }}		{{STRUCTURE_1jy4\| PDB=1jy4 \| SCENE= }}

-	~~'''~~B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND~~'''~~	+	===B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND===


-	~~==Overview==~~	+	<!--
-	The ~~design and characterization of an open eight-stranded beta-sheet in a synthetic~~, ~~2-fold symmetric 70-residue peptide is described. The design strategy involves~~ the ~~generation of a 35-residue four-stranded beta-sheet peptide in which successive hairpins are nucleated by appropriately positioned~~ (~~D)Pro-Xxx sequences. Oxidative dimerization using a single Cys residue positioned~~ at ~~the center of the C-terminal strand results in a disulfide-bridged eight-stranded structure~~. ~~Nuclear Overhauser effects firmly establish an eight-stranded beta-sheet in methanol~~. ~~In water~~, the ~~outer strands are frayed, but a well-defined four-stranded beta-sheet stabilized by a disulfide bridge and a hydrophobic cluster is determined from NMR data~~. ~~Comparison of the precursor peptide with the disulfide~~-~~bridged dimer reveals considerable enhancement of beta~~-~~sheet content in the latter, suggesting that the disulfide cross-link is an effective strategy for the stabilization of beta-sheets.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_11982362}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11982362 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11982362}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA].

	==Reference==		==Reference==
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	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Eight-stranded beta-sheet]]		[[Category: Eight-stranded beta-sheet]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 22~~:03:54 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:36 2008''