1jyj - Revision history

OCA at 08:48, 16 August 2023

OCA — Wed, 16 Aug 2023 08:48:01 GMT

←Older revision		Revision as of 08:48, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1jyj' size='340' side='right'caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jyj' size='340' side='right'caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [https://pdbe.org/1jyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [https://www.ebi.ac.uk/pdbsum/1jyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [https://pdbe.org/1jyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [https://www.ebi.ac.uk/pdbsum/1jyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.	+	[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.	+	[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Brew, K]]	+	[[Category: Brew K]]
-	[[Category: Chrysina~~, E D~~]]	+	[[Category: Chrysina ED]]
-	[[Category: Greene~~, L H~~]]	+	[[Category: Greene LH]]
-	[[Category: Irons~~, L I~~]]	+	[[Category: Irons LI]]
-	[[Category: Papageorgiou~~, A C]]~~	+	[[Category: Papageorgiou AC]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Lipocalin family]]~~	+
-	~~[[Category: Retinol binding protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:44, 21 April 2021

OCA — Wed, 21 Apr 2021 08:44:10 GMT

←Older revision		Revision as of 08:44, 21 April 2021
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	<StructureSection load='1jyj' size='340' side='right'caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jyj' size='340' side='right'caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [~~http~~://pdbe.org/1jyj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jyj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [https://pdbe.org/1jyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [https://www.ebi.ac.uk/pdbsum/1jyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[~~http~~://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.	+	[[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.	+	[[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Retinol-binding protein\|Retinol-binding protein]]	+	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:29, 17 July 2019

OCA — Wed, 17 Jul 2019 13:29:42 GMT

←Older revision		Revision as of 13:29, 17 July 2019
Line 1:		Line 1:

	==Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution==		==Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution==
-	<StructureSection load='1jyj' size='340' side='right' caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1jyj' size='340' side='right'caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1jyj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jyj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Retinol-binding protein\|Retinol-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Brew, K]]		[[Category: Brew, K]]

OCA at 07:19, 11 October 2017

OCA — Wed, 11 Oct 2017 07:19:53 GMT

←Older revision		Revision as of 07:19, 11 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution==		==Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution==
	<StructureSection load='1jyj' size='340' side='right' caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jyj' size='340' side='right' caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [http://pdbe.org/1jyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [http://www.ebi.ac.uk/pdbsum/1jyj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [http://pdbe.org/1jyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [http://www.ebi.ac.uk/pdbsum/1jyj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1jyj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jyj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Retinol-binding protein\|Retinol-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:34, 11 September 2015

OCA — Fri, 11 Sep 2015 11:34:30 GMT

←Older revision		Revision as of 11:34, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jyj' size='340' side='right' caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1jyj' size='340' side='right' caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [http://www.ebi.ac.uk/pdbsum/1jyj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [http://pdbe.org/1jyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [http://www.ebi.ac.uk/pdbsum/1jyj PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jyj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Brew, K]]		[[Category: Brew, K]]

OCA at 12:10, 2 January 2015

OCA — Fri, 02 Jan 2015 12:10:10 GMT

←Older revision		Revision as of 12:10, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [http://www.ebi.ac.uk/pdbsum/1jyj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [http://www.ebi.ac.uk/pdbsum/1jyj PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.		[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Brew, K.]]	+	[[Category: Brew, K]]
-	[[Category: Chrysina, E D.]]	+	[[Category: Chrysina, E D]]
-	[[Category: Greene, L H.]]	+	[[Category: Greene, L H]]
-	[[Category: Irons, L I.]]	+	[[Category: Irons, L I]]
-	[[Category: Papageorgiou, A C.]]	+	[[Category: Papageorgiou, A C]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Lipocalin family]]		[[Category: Lipocalin family]]
	[[Category: Retinol binding protein]]		[[Category: Retinol binding protein]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 14:42, 29 September 2014

OCA — Mon, 29 Sep 2014 14:42:37 GMT

←Older revision		Revision as of 14:42, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1jyj\| PDB=1jyj \| SCENE= }}~~	+	==Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution==
-	===Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution===	+	<StructureSection load='1jyj' size='340' side='right' caption='[[1jyj]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_11604536}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYJ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rbp\|1rbp]], [[1brp\|1brp]], [[1brq\|1brq]], [[1jyd\|1jyd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyj RCSB], [http://www.ebi.ac.uk/pdbsum/1jyj PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.		[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.		[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Serum retinol binding protein (RBP) is a member of the lipocalin family, proteins with up-and-down beta-barrel folds, low levels of sequence identity, and diverse functions. Although tryptophan 24 of RBP is highly conserved among lipocalins, it does not play a direct role in activity. To determine if Trp24 and other conserved residues have roles in stability and/or folding, we investigated the effects of conservative substitutions for the four tryptophans and some adjacent residues on the structure, stability, and spectroscopic properties of apo-RBP. Crystal structures of recombinant human apo-RBP and of a mutant with substitutions for tryptophans 67 and 91 at 1.7 A and 2.0 A resolution, respectively, as well as stability measurements, indicate that these relatively exposed tryptophans have little influence on structure or stability. Although Trp105 is largely buried in the wall of the beta-barrel, it can be replaced with minor effects on stability to thermal and chemical unfolding. In contrast, substitutions of three different amino acids for Trp24 or replacement of Arg139, a conserved residue that interacts with Trp24, lead to similar large losses in stability and lower yields of native protein generated by in vitro folding. The results and the coordinated nature of natural substitutions at these sites support the idea that conserved residues in functionally divergent homologs have roles in stabilizing the native relative to misfolded structures. They also establish conditions for studies of the kinetics of folding and unfolding by identifying spectroscopic signals for monitoring the formation of different substructures.

-	~~==About this Structure==~~	+	Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily.,Greene LH, Chrysina ED, Irons LI, Papageorgiou AC, Acharya KR, Brew K Protein Sci. 2001 Nov;10(11):2301-16. PMID:11604536<ref>PMID:11604536</ref>
-	~~[[1jyj]] is a 1 chain~~ structure ~~with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1JYJ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Retinol-binding protein\|Retinol-binding protein]]		*[[Retinol-binding protein\|Retinol-binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:011604536</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]

OCA at 11:30, 24 March 2013

OCA — Sun, 24 Mar 2013 11:30:50 GMT

←Older revision		Revision as of 11:30, 24 March 2013
Line 1:		Line 1:
-	[[Image:1jyj.png\|left\|200px]]
-
	{{STRUCTURE_1jyj\| PDB=1jyj \| SCENE= }}		{{STRUCTURE_1jyj\| PDB=1jyj \| SCENE= }}
-
	===Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution===		===Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution===
		+	{{ABSTRACT_PUBMED_11604536}}

-	~~{{ABSTRACT_PUBMED_11604536}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011604536</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011604536</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]

OCA at 18:35, 20 October 2012

OCA — Sat, 20 Oct 2012 18:35:36 GMT

←Older revision		Revision as of 18:35, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1jyj]] is a 1 chain structure ~~of [[Retinol-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA].	+	[[1jyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYJ OCA].

	==See Also==		==See Also==

OCA: Protected "1jyj" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 04:34:28 GMT

Protected "1jyj" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:34, 27 July 2012