1jyt - Revision history

OCA at 08:39, 22 May 2024

OCA — Wed, 22 May 2024 08:39:37 GMT

←Older revision		Revision as of 08:39, 22 May 2024
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyt ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Olfactory marker protein (OMP) is a ubiquitous, cytoplasmic protein found in mature olfactory receptor neurons of all vertebrates. Electrophysiological and behavioral studies demonstrate that it is a modulator of the olfactory signal transduction pathway. Here, we demonstrate that the solution structure of OMP, as determined by NMR studies, is a single globular domain protein comprised of eight beta-strands forming two beta-sheets oriented orthogonally to one another, thus exhibiting a "beta-clam" or "beta-sandwich" fold: beta-sheet 1 is comprised of beta3-beta8-beta1-beta2 and beta-sheet 2 contains beta6-beta5-beta4-beta7. Insertions include two, long alpha-helices located on opposite sides of the beta-clam and three flexible loops. The juxtaposition of beta-strands beta6-beta5-beta4-beta7-beta2-beta1-beta8-beta3 forms a continuously curved surface and encloses one side of the beta-clam. The "cleft" formed by the two beta-sheets is opposite to the closed end of the beta-clam. Using a peptide titration series, we have identified this cleft as the binding surface for a peptide derived from the Bex1 protein. The highly conserved Omega-loop structure adjacent to the Bex1 peptide-binding surface found in OMP may be the site of additional OMP-protein interactions related to its role in modulating olfactory signal transduction. Thus, the interaction between the OMP and Bex1 proteins could facilitate the interaction between OMP and other components of the olfactory signaling pathway.
		+
		+	Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.,Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL J Mol Biol. 2002 Jun 7;319(3):823-37. PMID:12054873<ref>PMID:12054873</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1jyt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:56, 3 April 2024

OCA — Wed, 03 Apr 2024 07:56:08 GMT

←Older revision		Revision as of 07:56, 3 April 2024
Line 1:		Line 1:

	==Solution structure of olfactory marker protein from rat==		==Solution structure of olfactory marker protein from rat==
-	<StructureSection load='1jyt' size='340' side='right'caption='[[1jyt~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1jyt' size='340' side='right'caption='[[1jyt]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [https://pdbe.org/1jyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [https://www.ebi.ac.uk/pdbsum/1jyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyt ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [https://pdbe.org/1jyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [https://www.ebi.ac.uk/pdbsum/1jyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/OMP_RAT OMP_RAT]] May act as a modulator of the olfactory signal-transduction cascade.	+	[https://www.uniprot.org/uniprot/OMP_RAT OMP_RAT] May act as a modulator of the olfactory signal-transduction cascade.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyt ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Olfactory marker protein (OMP) is a ubiquitous, cytoplasmic protein found in mature olfactory receptor neurons of all vertebrates. Electrophysiological and behavioral studies demonstrate that it is a modulator of the olfactory signal transduction pathway. Here, we demonstrate that the solution structure of OMP, as determined by NMR studies, is a single globular domain protein comprised of eight beta-strands forming two beta-sheets oriented orthogonally to one another, thus exhibiting a "beta-clam" or "beta-sandwich" fold: beta-sheet 1 is comprised of beta3-beta8-beta1-beta2 and beta-sheet 2 contains beta6-beta5-beta4-beta7. Insertions include two, long alpha-helices located on opposite sides of the beta-clam and three flexible loops. The juxtaposition of beta-strands beta6-beta5-beta4-beta7-beta2-beta1-beta8-beta3 forms a continuously curved surface and encloses one side of the beta-clam. The "cleft" formed by the two beta-sheets is opposite to the closed end of the beta-clam. Using a peptide titration series, we have identified this cleft as the binding surface for a peptide derived from the Bex1 protein. The highly conserved Omega-loop structure adjacent to the Bex1 peptide-binding surface found in OMP may be the site of additional OMP-protein interactions related to its role in modulating olfactory signal transduction. Thus, the interaction between the OMP and Bex1 proteins could facilitate the interaction between OMP and other components of the olfactory signaling pathway.
-
-	Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.,Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL J Mol Biol. 2002 Jun 7;319(3):823-37. PMID:12054873<ref>PMID:12054873</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jyt" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Baldisseri, D M~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Koo, J H~~]]	+	[[Category: Baldisseri DM]]
-	[[Category: ~~Margolis, F M~~]]	+	[[Category: Koo JH]]
-	[[Category: Margolis~~, J W~~]]	+	[[Category: Margolis FM]]
-	[[Category: ~~Weber, D J~~]]	+	[[Category: Margolis JW]]
-	[[Category: ~~Beta-clambshell]]~~	+	[[Category: Weber DJ]]
-	~~[[Category: Omega-loop]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:47, 11 August 2021

OCA — Wed, 11 Aug 2021 06:47:04 GMT

←Older revision		Revision as of 06:47, 11 August 2021
Line 3:		Line 3:
	<StructureSection load='1jyt' size='340' side='right'caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1jyt' size='340' side='right'caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [~~http~~://pdbe.org/1jyt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jyt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyt ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [https://pdbe.org/1jyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [https://www.ebi.ac.uk/pdbsum/1jyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/OMP_RAT OMP_RAT]] May act as a modulator of the olfactory signal-transduction cascade.	+	[[https://www.uniprot.org/uniprot/OMP_RAT OMP_RAT]] May act as a modulator of the olfactory signal-transduction cascade.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:00, 6 November 2019

OCA — Wed, 06 Nov 2019 09:00:15 GMT

←Older revision		Revision as of 09:00, 6 November 2019
Line 1:		Line 1:

	==Solution structure of olfactory marker protein from rat==		==Solution structure of olfactory marker protein from rat==
-	<StructureSection load='1jyt' size='340' side='right' caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1jyt' size='340' side='right'caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Baldisseri, D M]]		[[Category: Baldisseri, D M]]
	[[Category: Koo, J H]]		[[Category: Koo, J H]]

OCA at 08:37, 17 January 2018

OCA — Wed, 17 Jan 2018 08:37:33 GMT

←Older revision		Revision as of 08:37, 17 January 2018
Line 1:		Line 1:
		+
	==Solution structure of olfactory marker protein from rat==		==Solution structure of olfactory marker protein from rat==
	<StructureSection load='1jyt' size='340' side='right' caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1jyt' size='340' side='right' caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [http://pdbe.org/1jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [http://www.ebi.ac.uk/pdbsum/1jyt PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [http://pdbe.org/1jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [http://www.ebi.ac.uk/pdbsum/1jyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:07, 9 February 2016

OCA — Tue, 09 Feb 2016 07:07:48 GMT

←Older revision		Revision as of 07:07, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:48, 10 September 2015

OCA — Thu, 10 Sep 2015 19:48:58 GMT

←Older revision		Revision as of 19:48, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1jyt' size='340' side='right' caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1jyt' size='340' side='right' caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [http://www.ebi.ac.uk/pdbsum/1jyt PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [http://pdbe.org/1jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [http://www.ebi.ac.uk/pdbsum/1jyt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jyt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Baldisseri, D M]]		[[Category: Baldisseri, D M]]
	[[Category: Koo, J H]]		[[Category: Koo, J H]]

OCA at 05:14, 25 December 2014

OCA — Thu, 25 Dec 2014 05:14:41 GMT

←Older revision		Revision as of 05:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [http://www.ebi.ac.uk/pdbsum/1jyt PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [http://www.ebi.ac.uk/pdbsum/1jyt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OMP_RAT OMP_RAT]] May act as a modulator of the olfactory signal-transduction cascade.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Baldisseri, D M.]]	+	[[Category: Baldisseri, D M]]
-	[[Category: Koo, J H.]]	+	[[Category: Koo, J H]]
-	[[Category: Margolis, F M.]]	+	[[Category: Margolis, F M]]
-	[[Category: Margolis, J W.]]	+	[[Category: Margolis, J W]]
-	[[Category: Weber, D J.]]	+	[[Category: Weber, D J]]
	[[Category: Beta-clambshell]]		[[Category: Beta-clambshell]]
	[[Category: Omega-loop]]		[[Category: Omega-loop]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 12:22, 28 September 2014

OCA — Sun, 28 Sep 2014 12:22:28 GMT

←Older revision		Revision as of 12:22, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1jyt.~~png\|left~~\|200px]]	+	==Solution structure of olfactory marker protein from rat==
		+	<StructureSection load='1jyt' size='340' side='right' caption='[[1jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyt RCSB], [http://www.ebi.ac.uk/pdbsum/1jyt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Olfactory marker protein (OMP) is a ubiquitous, cytoplasmic protein found in mature olfactory receptor neurons of all vertebrates. Electrophysiological and behavioral studies demonstrate that it is a modulator of the olfactory signal transduction pathway. Here, we demonstrate that the solution structure of OMP, as determined by NMR studies, is a single globular domain protein comprised of eight beta-strands forming two beta-sheets oriented orthogonally to one another, thus exhibiting a "beta-clam" or "beta-sandwich" fold: beta-sheet 1 is comprised of beta3-beta8-beta1-beta2 and beta-sheet 2 contains beta6-beta5-beta4-beta7. Insertions include two, long alpha-helices located on opposite sides of the beta-clam and three flexible loops. The juxtaposition of beta-strands beta6-beta5-beta4-beta7-beta2-beta1-beta8-beta3 forms a continuously curved surface and encloses one side of the beta-clam. The "cleft" formed by the two beta-sheets is opposite to the closed end of the beta-clam. Using a peptide titration series, we have identified this cleft as the binding surface for a peptide derived from the Bex1 protein. The highly conserved Omega-loop structure adjacent to the Bex1 peptide-binding surface found in OMP may be the site of additional OMP-protein interactions related to its role in modulating olfactory signal transduction. Thus, the interaction between the OMP and Bex1 proteins could facilitate the interaction between OMP and other components of the olfactory signaling pathway.

-	~~{{STRUCTURE_1jyt\| PDB=1jyt \| SCENE= }}~~	+	Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.,Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL J Mol Biol. 2002 Jun 7;319(3):823-37. PMID:12054873<ref>PMID:12054873</ref>

-	~~===Solution structure~~ of ~~olfactory marker protein from rat===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12054873}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jyt]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JYT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012054873<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Baldisseri, D M.]]		[[Category: Baldisseri, D M.]]

OCA: Protected "1jyt" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:09:31 GMT

Protected "1jyt" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:09, 5 December 2012