1jz2 - Revision history

OCA at 08:48, 16 August 2023

OCA — Wed, 16 Aug 2023 08:48:16 GMT

←Older revision		Revision as of 08:48, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1jz2' size='340' side='right'caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1jz2' size='340' side='right'caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [https://pdbe.org/1jz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [https://www.ebi.ac.uk/pdbsum/1jz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jz2 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [~~http~~://pdbe.org/1jz2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jz2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jz2 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BGAL_ECOLI BGAL_ECOLI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Beta-galactosidase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Juers~~, D H~~]]	+	[[Category: Juers DH]]
-	[[Category: Mackenzie, L]]	+	[[Category: Mackenzie L]]
-	[[Category: Matthews~~, B W~~]]	+	[[Category: Matthews BW]]
-	[[Category: McCarter~~, J D~~]]	+	[[Category: McCarter JD]]
-	[[Category: Withers~~, S G]]~~	+	[[Category: Withers SG]]
-	~~[[Category: Beta supersandwich]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Jelly-roll barrel~~]]	+

OCA at 07:38, 25 November 2020

OCA — Wed, 25 Nov 2020 07:38:05 GMT

←Older revision		Revision as of 07:38, 25 November 2020
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	==E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)==		==E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)==
-	<StructureSection load='1jz2' size='340' side='right' caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1jz2' size='340' side='right'caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://pdbe.org/1jz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jz2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://pdbe.org/1jz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jz2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1jz2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jz2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galactosidase 3D structures\|Galactosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-galactosidase]]		[[Category: Beta-galactosidase]]
		+	[[Category: Large Structures]]
	[[Category: Juers, D H]]		[[Category: Juers, D H]]
	[[Category: Mackenzie, L]]		[[Category: Mackenzie, L]]

OCA at 09:01, 17 January 2018

OCA — Wed, 17 Jan 2018 09:01:13 GMT

←Older revision		Revision as of 09:01, 17 January 2018
Line 1:		Line 1:
		+
	==E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)==		==E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)==
	<StructureSection load='1jz2' size='340' side='right' caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1jz2' size='340' side='right' caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://pdbe.org/1jz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://pdbe.org/1jz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jz2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jz2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jz2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1jz2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jz2" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Galactosidase\|Galactosidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:18, 9 February 2016

OCA — Tue, 09 Feb 2016 01:18:32 GMT

←Older revision		Revision as of 01:18, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jz2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:12, 10 September 2015

OCA — Thu, 10 Sep 2015 17:12:39 GMT

←Older revision		Revision as of 17:12, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1jz2' size='340' side='right' caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1jz2' size='340' side='right' caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://pdbe.org/1jz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jz2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-galactosidase]]		[[Category: Beta-galactosidase]]
-	[[Category: Escherichia coli]]
	[[Category: Juers, D H]]		[[Category: Juers, D H]]
	[[Category: Mackenzie, L]]		[[Category: Mackenzie, L]]

OCA at 12:02, 2 January 2015

OCA — Fri, 02 Jan 2015 12:02:55 GMT

←Older revision		Revision as of 12:02, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Beta-galactosidase]]		[[Category: Beta-galactosidase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Juers, D H.]]	+	[[Category: Juers, D H]]
-	[[Category: Mackenzie, L.]]	+	[[Category: Mackenzie, L]]
-	[[Category: Matthews, B W.]]	+	[[Category: Matthews, B W]]
-	[[Category: McCarter, J D.]]	+	[[Category: McCarter, J D]]
-	[[Category: Withers, S G.]]	+	[[Category: Withers, S G]]
	[[Category: Beta supersandwich]]		[[Category: Beta supersandwich]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
	[[Category: Jelly-roll barrel]]		[[Category: Jelly-roll barrel]]

OCA at 09:29, 28 September 2014

OCA — Sun, 28 Sep 2014 09:29:39 GMT

←Older revision		Revision as of 09:29, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jz2.~~png~~\|~~left~~\|200px]]	+	==E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)==
		+	<StructureSection load='1jz2' size='340' side='right' caption='[[1jz2]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZ2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FG:2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE'>2FG</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dp0\|1dp0]], [[1f49\|1f49]], [[1jyn\|1jyn]], [[1jyv\|1jyv]], [[1jyw\|1jyw]], [[1jyx\|1jyx]], [[1jyy\|1jyy]], [[1jyz\|1jyz]], [[1jz0\|1jz0]], [[1jz1\|1jz1]], [[1jz3\|1jz3]], [[1jz4\|1jz4]], [[1jz5\|1jz5]], [[1jz6\|1jz6]], [[1jz7\|1jz7]], [[1jz8\|1jz8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lacZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jz2 RCSB], [http://www.ebi.ac.uk/pdbsum/1jz2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jz2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structures of a series of complexes designed to mimic intermediates along the reaction coordinate for beta-galactosidase are presented. These complexes clarify and enhance previous proposals regarding the catalytic mechanism. The nucleophile, Glu537, is seen to covalently bind to the galactosyl moiety. Of the two potential acids, Mg(2+) and Glu461, the latter is in better position to directly assist in leaving group departure, suggesting that the metal ion acts in a secondary role. A sodium ion plays a part in substrate binding by directly ligating the galactosyl 6-hydroxyl. The proposed reaction coordinate involves the movement of the galactosyl moiety deep into the active site pocket. For those ligands that do bind deeply there is an associated conformational change in which residues within loop 794-804 move up to 10 A closer to the site of binding. In some cases this can be inhibited by the binding of additional ligands. The resulting restricted access to the intermediate helps to explain why allolactose, the natural inducer for the lac operon, is the preferred product of transglycosylation.

-	~~{{STRUCTURE_1jz2\| PDB=1jz2 \| SCENE= }}~~	+	A structural view of the action of Escherichia coli (lacZ) beta-galactosidase.,Juers DH, Heightman TD, Vasella A, McCarter JD, Mackenzie L, Withers SG, Matthews BW Biochemistry. 2001 Dec 11;40(49):14781-94. PMID:11732897<ref>PMID:11732897</ref>

-	~~===E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11732897}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jz2]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA].~~	+

	==See Also==		==See Also==
	*[[Galactosidase\|Galactosidase]]		*[[Galactosidase\|Galactosidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011732897<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-galactosidase]]		[[Category: Beta-galactosidase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA at 12:08, 20 October 2012

OCA — Sat, 20 Oct 2012 12:08:37 GMT

←Older revision		Revision as of 12:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1jz2]] is a 4 chain structure ~~of [[Galactosidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA].	+	[[1jz2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA].

	==See Also==		==See Also==

OCA: Protected "1jz2" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 07:45:58 GMT

Protected "1jz2" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:45, 26 July 2012

OCA at 07:45, 26 July 2012

OCA — Thu, 26 Jul 2012 07:45:57 GMT

←Older revision		Revision as of 07:45, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jz2.png\|left\|200px]]		[[Image:1jz2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jz2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jz2\| PDB=1jz2 \| SCENE= }}		{{STRUCTURE_1jz2\| PDB=1jz2 \| SCENE= }}

	===E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)===		===E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11732897}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11732897 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11732897}}		{{ABSTRACT_PUBMED_11732897}}

	==About this Structure==		==About this Structure==
-	~~1JZ2~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA].	+	[[1jz2]] is a 4 chain structure of [[Galactosidase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZ2 OCA].
		+
		+	==See Also==
		+	*[[Galactosidase\|Galactosidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11732897~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011732897</ref><references group="xtra"/>
	[[Category: Beta-galactosidase]]		[[Category: Beta-galactosidase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
Line 32:		Line 23:
	[[Category: Withers, S G.]]		[[Category: Withers, S G.]]
	[[Category: Beta supersandwich]]		[[Category: Beta supersandwich]]
		+	[[Category: Hydrolase]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
	[[Category: Jelly-roll barrel]]		[[Category: Jelly-roll barrel]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:17:42 2009''