1jza - Revision history

OCA at 08:48, 16 August 2023

OCA — Wed, 16 Aug 2023 08:48:24 GMT

←Older revision		Revision as of 08:48, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1jza' size='340' side='right'caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1jza' size='340' side='right'caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bark_scorpion Bark scorpion~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZA FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1jzb~~\|~~1jzb~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [https://pdbe.org/1jza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [https://www.ebi.ac.uk/pdbsum/1jza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jza ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [https://pdbe.org/1jza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [https://www.ebi.ac.uk/pdbsum/1jza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SCX2_CENSC SCX2_CENSC]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref>	+	[https://www.uniprot.org/uniprot/SCX2_CENSC SCX2_CENSC] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bark scorpion~~]]	+	[[Category: Centruroides sculpturatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cook~~, W J~~]]	+	[[Category: Cook WJ]]
-	[[Category: Ealick~~, S E~~]]	+	[[Category: Ealick SE]]
-	[[Category: Watt~~, D D~~]]	+	[[Category: Watt DD]]
-	[[Category: Zell, A]]	+	[[Category: Zell A]]
-	~~[[Category: Noncrystallographic symmetry]]~~	+
-	~~[[Category: Scorpion toxin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 08:44, 21 April 2021

OCA — Wed, 21 Apr 2021 08:44:13 GMT

←Older revision		Revision as of 08:44, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='1jza' size='340' side='right'caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1jza' size='340' side='right'caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bark_scorpion Bark scorpion]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JZA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bark_scorpion Bark scorpion]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZA FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jzb\|1jzb]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [~~http~~://pdbe.org/1jza PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jza PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jza ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [https://pdbe.org/1jza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [https://www.ebi.ac.uk/pdbsum/1jza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SCX2_CENSC SCX2_CENSC]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref>	+	[[https://www.uniprot.org/uniprot/SCX2_CENSC SCX2_CENSC]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:44, 17 July 2019

OCA — Wed, 17 Jul 2019 13:44:50 GMT

←Older revision		Revision as of 13:44, 17 July 2019
Line 1:		Line 1:

	==Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing==		==Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing==
-	<StructureSection load='1jza' size='340' side='right' caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1jza' size='340' side='right'caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bark_scorpion Bark scorpion]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bark_scorpion Bark scorpion]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jza_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jza_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bark scorpion]]		[[Category: Bark scorpion]]
		+	[[Category: Large Structures]]
	[[Category: Cook, W J]]		[[Category: Cook, W J]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]

OCA at 07:33, 11 October 2017

OCA — Wed, 11 Oct 2017 07:33:23 GMT

←Older revision		Revision as of 07:33, 11 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing==		==Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing==
	<StructureSection load='1jza' size='340' side='right' caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1jza' size='340' side='right' caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Centruroides_sculpturatus Centruroides sculpturatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bark_scorpion Bark scorpion]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [http://pdbe.org/1jza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [http://www.ebi.ac.uk/pdbsum/1jza PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [http://pdbe.org/1jza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [http://www.ebi.ac.uk/pdbsum/1jza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jza ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Centruroides sculpturatus~~]]	+	[[Category: Bark scorpion]]
	[[Category: Cook, W J]]		[[Category: Cook, W J]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]

OCA at 07:21, 11 September 2015

OCA — Fri, 11 Sep 2015 07:21:49 GMT

←Older revision		Revision as of 07:21, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [http://www.ebi.ac.uk/pdbsum/1jza PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [http://pdbe.org/1jza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [http://www.ebi.ac.uk/pdbsum/1jza PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jza" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:09, 25 December 2014

OCA — Thu, 25 Dec 2014 13:09:45 GMT

←Older revision		Revision as of 13:09, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [http://www.ebi.ac.uk/pdbsum/1jza PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [http://www.ebi.ac.uk/pdbsum/1jza PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCX2_CENSC SCX2_CENSC]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Centruroides sculpturatus]]		[[Category: Centruroides sculpturatus]]
-	[[Category: Cook, W J.]]	+	[[Category: Cook, W J]]
-	[[Category: Ealick, S E.]]	+	[[Category: Ealick, S E]]
-	[[Category: Watt, D D.]]	+	[[Category: Watt, D D]]
-	[[Category: Zell, A.]]	+	[[Category: Zell, A]]
	[[Category: Noncrystallographic symmetry]]		[[Category: Noncrystallographic symmetry]]
	[[Category: Scorpion toxin]]		[[Category: Scorpion toxin]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 11:34, 28 September 2014

OCA — Sun, 28 Sep 2014 11:34:16 GMT

←Older revision		Revision as of 11:34, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jza.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing==
		+	<StructureSection load='1jza' size='340' side='right' caption='[[1jza]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jzb\|1jzb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jza RCSB], [http://www.ebi.ac.uk/pdbsum/1jza PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jza_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Centruroides sculpturatus Ewing variant 2 toxin (CsE-v2) is a neurotoxin isolated from the venom of a scorpion native to the Arizona desert. The structure of CsE-v2 was solved in two different crystal forms using a combination of molecular replacement and multiple isomorphous replacement techniques. Crystals of CsE-v2 display a temperature-dependent, reversible-phase transition near room temperature. At lower temperature the space group changes from P3(2)21 to P3(1)21 with an approximate doubling of the C-axis. The small-cell structure, which has one molecule per asymmetric unit, has an R factor of 0.229 at 2.8 A resolution. The large-cell structure has two molecules per asymmetric unit and was refined at 2.2 A resolution to an R factor of 0.255. CsE-v2 is a rigid, compact structure with four intrachain disulfide bonds. The structure is similar to other long-chain beta neurotoxins, and the largest differences occur in the last six residues. The high-resolution structure of CsE-v2 corrects an error in the reported C-terminal sequence; the terminal tripeptide sequence is Ser 64-Cys 65-Ser 66 rather than Ser 64-Ser 65-Cys 66. Comparison of CsE-v2 with long-chain alpha toxins reveals four insertions and one deletion, as well as additional residues at the N and C termini. Structural alignment of alpha and beta toxins suggests that the primary distinguishing feature between the two classes is the length of the loop between the second and third strands in a three-strand beta sheet. The shorter loop in alpha toxins exposes a critical lysine side chain, whereas the longer loop in beta toxins buries the corresponding basic residue (either arginine or lysine).

-	~~{{STRUCTURE_1jza\| PDB=1jza \| SCENE= }}~~	+	Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing.,Cook WJ, Zell A, Watt DD, Ealick SE Protein Sci. 2002 Mar;11(3):479-86. PMID:11847271<ref>PMID:11847271</ref>

-	~~===Crystal Structure~~ of ~~Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11847271}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1jza]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011847271<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Centruroides sculpturatus]]		[[Category: Centruroides sculpturatus]]
	[[Category: Cook, W J.]]		[[Category: Cook, W J.]]

OCA: Protected "1jza" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 11:37:09 GMT

Protected "1jza" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:37, 5 December 2012

OCA at 11:37, 5 December 2012

OCA — Wed, 05 Dec 2012 11:37:06 GMT

←Older revision		Revision as of 11:37, 5 December 2012
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-	{{Seed}}
	[[Image:1jza.png\|left\|200px]]		[[Image:1jza.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jza", creates the "Structure Box" on the page.
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	{{STRUCTURE_1jza\| PDB=1jza \| SCENE= }}		{{STRUCTURE_1jza\| PDB=1jza \| SCENE= }}

	===Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing===		===Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11847271}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_11847271}}		{{ABSTRACT_PUBMED_11847271}}

	==About this Structure==		==About this Structure==
-	~~1JZA~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA].	+	[[1jza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11847271~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011847271</ref><references group="xtra"/>
	[[Category: Centruroides sculpturatus]]		[[Category: Centruroides sculpturatus]]
	[[Category: Cook, W J.]]		[[Category: Cook, W J.]]
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	[[Category: Watt, D D.]]		[[Category: Watt, D D.]]
	[[Category: Zell, A.]]		[[Category: Zell, A.]]
-	[[Category: Crystal structure]]
	[[Category: Noncrystallographic symmetry]]		[[Category: Noncrystallographic symmetry]]
	[[Category: Scorpion toxin]]		[[Category: Scorpion toxin]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 17:02:53 2009''~~	+

OCA at 15:02, 17 February 2009

OCA — Tue, 17 Feb 2009 15:02:55 GMT

←Older revision		Revision as of 15:02, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1JZA is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA].	+	1JZA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZA OCA].

	==Reference==		==Reference==
-	~~Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing., Cook WJ, Zell A, Watt DD, Ealick SE, Protein Sci. 2002 Mar;11(3):479-86.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11847271 11847271]~~	+	<ref group="xtra">PMID:11847271</ref><references group="xtra"/>
	[[Category: Centruroides sculpturatus]]		[[Category: Centruroides sculpturatus]]
-	[[Category: Single protein]]
	[[Category: Cook, W J.]]		[[Category: Cook, W J.]]
	[[Category: Ealick, S E.]]		[[Category: Ealick, S E.]]
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	[[Category: Scorpion toxin]]		[[Category: Scorpion toxin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 23~~:53:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:02:53 2009''