1jzl - Revision history

OCA at 08:48, 16 August 2023

OCA — Wed, 16 Aug 2023 08:48:41 GMT

←Older revision		Revision as of 08:48, 16 August 2023
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	<StructureSection load='1jzl' size='340' side='right'caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jzl' size='340' side='right'caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>~~, ~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1jwn\|1jwn]]~~, ~~[[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [https://pdbe.org/1jzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [https://www.ebi.ac.uk/pdbsum/1jzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [https://pdbe.org/1jzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [https://www.ebi.ac.uk/pdbsum/1jzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anadara inaequivalvis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cushing, L]]	+	[[Category: Cushing L]]
-	[[Category: Gibson~~, Q H~~]]	+	[[Category: Gibson QH]]
-	[[Category: Knapp~~, J E~~]]	+	[[Category: Knapp JE]]
-	[[Category: Royer~~, W E]]~~	+	[[Category: Royer Jr WE]]
-	~~[[Category: Allostery]]~~	+
-	~~[[Category: Cooperativity]]~~	+
-	~~[[Category: Heme protein]]~~	+
-	~~[[Category: Hemoglobin]]~~	+
-	~~[[Category: Invertebrate]]~~	+
-	~~[[Category: Oxygen storage-transport complex]]~~	+
-	~~[[Category: Oxygen-binding]]~~	+
-	~~[[Category: Oxygen-transport~~]]	+

OCA at 14:37, 27 October 2021

OCA — Wed, 27 Oct 2021 14:37:06 GMT

←Older revision		Revision as of 14:37, 27 October 2021
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	<StructureSection load='1jzl' size='340' side='right'caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jzl' size='340' side='right'caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure ~~with sequence from [https://en.wikipedia.org/wiki/Anain Anain]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</div></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anain]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cushing, L]]		[[Category: Cushing, L]]

OCA at 06:47, 11 August 2021

OCA — Wed, 11 Aug 2021 06:47:16 GMT

←Older revision		Revision as of 06:47, 11 August 2021
Line 3:		Line 3:
	<StructureSection load='1jzl' size='340' side='right'caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jzl' size='340' side='right'caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [~~http~~://pdbe.org/1jzl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jzl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [https://pdbe.org/1jzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [https://www.ebi.ac.uk/pdbsum/1jzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:29, 6 November 2019

OCA — Wed, 06 Nov 2019 09:29:42 GMT

←Older revision		Revision as of 09:29, 6 November 2019
Line 1:		Line 1:

	==Crystal structure of Sapharca inaequivalvis HbI, I114M mutant ligated to carbon monoxide.==		==Crystal structure of Sapharca inaequivalvis HbI, I114M mutant ligated to carbon monoxide.==
-	<StructureSection load='1jzl' size='340' side='right' caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1jzl' size='340' side='right'caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZL FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Anain]]		[[Category: Anain]]
		+	[[Category: Large Structures]]
	[[Category: Cushing, L]]		[[Category: Cushing, L]]
	[[Category: Gibson, Q H]]		[[Category: Gibson, Q H]]

OCA at 09:04, 17 January 2018

OCA — Wed, 17 Jan 2018 09:04:33 GMT

←Older revision		Revision as of 09:04, 17 January 2018
Line 1:		Line 1:
		+
	==Crystal structure of Sapharca inaequivalvis HbI, I114M mutant ligated to carbon monoxide.==		==Crystal structure of Sapharca inaequivalvis HbI, I114M mutant ligated to carbon monoxide.==
	<StructureSection load='1jzl' size='340' side='right' caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jzl' size='340' side='right' caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [http://pdbe.org/1jzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [http://www.ebi.ac.uk/pdbsum/1jzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [http://pdbe.org/1jzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [http://www.ebi.ac.uk/pdbsum/1jzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jzl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jzl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:23, 9 February 2016

OCA — Tue, 09 Feb 2016 15:23:40 GMT

←Older revision		Revision as of 15:23, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jzl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:33, 10 September 2015

OCA — Thu, 10 Sep 2015 23:33:15 GMT

←Older revision		Revision as of 23:33, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1jzl' size='340' side='right' caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1jzl' size='340' side='right' caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Scapharca_inaequivalvis Scapharca inaequivalvis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [http://www.ebi.ac.uk/pdbsum/1jzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [http://pdbe.org/1jzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [http://www.ebi.ac.uk/pdbsum/1jzl PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jzl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Scapharca inaequivalvis~~]]	+	[[Category: Anain]]
	[[Category: Cushing, L]]		[[Category: Cushing, L]]
	[[Category: Gibson, Q H]]		[[Category: Gibson, Q H]]

OCA at 16:51, 5 January 2015

OCA — Mon, 05 Jan 2015 16:51:15 GMT

←Older revision		Revision as of 16:51, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [http://www.ebi.ac.uk/pdbsum/1jzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [http://www.ebi.ac.uk/pdbsum/1jzl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
-	[[Category: Cushing, L.]]	+	[[Category: Cushing, L]]
-	[[Category: Gibson, Q H.]]	+	[[Category: Gibson, Q H]]
-	[[Category: Knapp, J E.]]	+	[[Category: Knapp, J E]]
-	[[Category: Royer, W E.]]	+	[[Category: Royer, W E]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Cooperativity]]		[[Category: Cooperativity]]

OCA at 09:33, 28 September 2014

OCA — Sun, 28 Sep 2014 09:33:40 GMT

←Older revision		Revision as of 09:33, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jzl.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Sapharca inaequivalvis HbI, I114M mutant ligated to carbon monoxide.==
		+	<StructureSection load='1jzl' size='340' side='right' caption='[[1jzl]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JZL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jwn\|1jwn]], [[1jzk\|1jzk]], [[3sdh\|3sdh]], [[4sdh\|4sdh]], [[1hbi\|1hbi]], [[3hbi\|3hbi]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jzl RCSB], [http://www.ebi.ac.uk/pdbsum/1jzl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jzl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cooperative ligand binding in the dimeric hemoglobin from the blood clam Scapharca inaequivalvis results primarily from tertiary, rather than quaternary, structural changes. Ligand binding is coupled with conformational changes of key residues, including Phe 97, which is extruded from the proximal heme pocket, and the heme group, which moves deeper into the heme pocket. We have tested the role of the heme movement in cooperative function by mutating Ile 114, at the base of the heme pocket. Replacement of this residue with a Met did not disturb the hemoglobin structure or significantly alter equilibrium ligand binding properties. In contrast, substitution with a Phe at position 114 inhibits the ligand-linked movement of the heme group, and substantially reduces oxygen affinity and cooperativity. As the extent of heme movement to the normal position of the ligated state is diminished, Phe 97 is inhibited from its movement into the interface upon ligand binding. These results indicate a tight coupling between these two key cooperative transitions and suggest that the heme movement may be an obligatory trigger for expulsion of Phe 97 from the heme pocket.

-	~~{{STRUCTURE_1jzl\| PDB=1jzl \| SCENE= }}~~	+	Restricting the ligand-linked heme movement in Scapharca dimeric hemoglobin reveals tight coupling between distal and proximal contributions to cooperativity.,Knapp JE, Gibson QH, Cushing L, Royer WE Jr Biochemistry. 2001 Dec 11;40(49):14795-805. PMID:11732898<ref>PMID:11732898</ref>

-	~~===Crystal structure of Sapharca inaequivalvis HbI~~, ~~I114M mutant ligated to carbon monoxide.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11732898}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jzl]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA].~~	+

	==See Also==		==See Also==
-	*[[Hemoglobin\|Hemoglobin]]	+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011732898<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
	[[Category: Cushing, L.]]		[[Category: Cushing, L.]]

OCA at 14:18, 20 October 2012

OCA — Sat, 20 Oct 2012 14:18:04 GMT

←Older revision		Revision as of 14:18, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1jzl]] is a 2 chain structure ~~of [[Hemoglobin]]~~ with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA].	+	[[1jzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZL OCA].

	==See Also==		==See Also==