1k7b - Revision history

OCA at 07:58, 3 April 2024

OCA — Wed, 03 Apr 2024 07:58:22 GMT

←Older revision		Revision as of 07:58, 3 April 2024
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	==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==		==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==
-	<StructureSection load='1k7b' size='340' side='right'caption='[[1k7b~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1k7b' size='340' side='right'caption='[[1k7b]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cotco Cotco~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K7B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [https://pdbe.org/1k7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [https://www.ebi.ac.uk/pdbsum/1k7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k7b ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [https://pdbe.org/1k7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [https://www.ebi.ac.uk/pdbsum/1k7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RSVR_COTJA RSVR_COTJA]] Responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus.	+	[https://www.uniprot.org/uniprot/RSVR_COTJA RSVR_COTJA] Responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k7b ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k7b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The cellular receptor for subgroup A avian leukosis and sarcoma virus (ALSV-A) is Tva, which contains a motif related to repeats in the low density lipoprotein receptor (LDLR) ligand binding repeat (LBr) and which is necessary for viral entry. As observed with LBr repeats of LDLR, the 47 residue LBr domain of Tva (sTva47) requires calcium during oxidative folding to form the correct disulfide bonds, and calcium enhances the structure of correctly oxidized sTva47, as well as its ability to bind the viral envelope protein (Env). However, solution nuclear magnetic resonance studies indicate that, even in the presence of excess calcium, sTva47 exists in an ensemble of conformations. Nonetheless, as reported here, the structure of the predominant sTva47 solution conformer closely resembles that of other LBr repeats, with identical S-S binding topology and octahedral calcium coordination. The location of W48 and other critical residues on the surface suggests a region of the molecule necessary for Env binding and to mediate post-binding events important for ALSV-A cell entry.
-
-	The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus.,Tonelli M, Peters RJ, James TL, Agard DA FEBS Lett. 2001 Dec 7;509(2):161-8. PMID:11768384<ref>PMID:11768384</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1k7b" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cotco~~]]	+	[[Category: Coturnix coturnix]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Agard~~, D A~~]]	+	[[Category: Agard DA]]
-	[[Category: James~~, T L~~]]	+	[[Category: James TL]]
-	[[Category: Peters~~, R J~~]]	+	[[Category: Peters RJ]]
-	[[Category: Tonelli, M]]	+	[[Category: Tonelli M]]
-	~~[[Category: 3-10 helix]]~~	+
-	~~[[Category: Beta hairpin]]~~	+
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 08:14, 10 November 2021

OCA — Wed, 10 Nov 2021 08:14:20 GMT

←Older revision		Revision as of 08:14, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1k7b' size='340' side='right'caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1k7b' size='340' side='right'caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cotco Cotco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1K7B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cotco Cotco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [~~http~~://pdbe.org/1k7b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1k7b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1k7b ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [https://pdbe.org/1k7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [https://www.ebi.ac.uk/pdbsum/1k7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RSVR_COTJA RSVR_COTJA]] Responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus.	+	[[https://www.uniprot.org/uniprot/RSVR_COTJA RSVR_COTJA]] Responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:12, 6 November 2019

OCA — Wed, 06 Nov 2019 09:12:50 GMT

←Older revision		Revision as of 09:12, 6 November 2019
Line 1:		Line 1:

	==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==		==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==
-	<StructureSection load='1k7b' size='340' side='right' caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1k7b' size='340' side='right'caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotco Cotco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotco Cotco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Cotco]]		[[Category: Cotco]]
		+	[[Category: Large Structures]]
	[[Category: Agard, D A]]		[[Category: Agard, D A]]
	[[Category: James, T L]]		[[Category: James, T L]]

OCA at 21:23, 24 January 2018

OCA — Wed, 24 Jan 2018 21:23:31 GMT

←Older revision		Revision as of 21:23, 24 January 2018
Line 1:		Line 1:
		+
	==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==		==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==
	<StructureSection load='1k7b' size='340' side='right' caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1k7b' size='340' side='right' caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotco Cotco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotco Cotco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [http://pdbe.org/1k7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [http://www.ebi.ac.uk/pdbsum/1k7b PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [http://pdbe.org/1k7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [http://www.ebi.ac.uk/pdbsum/1k7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/1k7b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/1k7b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:35, 9 February 2016

OCA — Tue, 09 Feb 2016 02:35:30 GMT

←Older revision		Revision as of 02:35, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k7b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:46, 10 September 2015

OCA — Thu, 10 Sep 2015 17:46:29 GMT

←Older revision		Revision as of 17:46, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1k7b' size='340' side='right' caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1k7b' size='340' side='right' caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Coturnix_coturnix Coturnix coturnix~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotco Cotco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [http://www.ebi.ac.uk/pdbsum/1k7b PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [http://pdbe.org/1k7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [http://www.ebi.ac.uk/pdbsum/1k7b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1k7b" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Coturnix coturnix~~]]	+	[[Category: Cotco]]
	[[Category: Agard, D A]]		[[Category: Agard, D A]]
	[[Category: James, T L]]		[[Category: James, T L]]

OCA at 03:49, 25 December 2014

OCA — Thu, 25 Dec 2014 03:49:20 GMT

←Older revision		Revision as of 03:49, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [http://www.ebi.ac.uk/pdbsum/1k7b PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [http://www.ebi.ac.uk/pdbsum/1k7b PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RSVR_COTJA RSVR_COTJA]] Responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Coturnix coturnix]]		[[Category: Coturnix coturnix]]
-	[[Category: Agard, D A.]]	+	[[Category: Agard, D A]]
-	[[Category: James, T L.]]	+	[[Category: James, T L]]
-	[[Category: Peters, R J.]]	+	[[Category: Peters, R J]]
-	[[Category: Tonelli, M.]]	+	[[Category: Tonelli, M]]
	[[Category: 3-10 helix]]		[[Category: 3-10 helix]]
	[[Category: Beta hairpin]]		[[Category: Beta hairpin]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 10:09, 28 September 2014

OCA — Sun, 28 Sep 2014 10:09:47 GMT

←Older revision		Revision as of 10:09, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1k7b.~~png\|left~~\|200px]]	+	==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==
		+	<StructureSection load='1k7b' size='340' side='right' caption='[[1k7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [http://www.ebi.ac.uk/pdbsum/1k7b PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/1k7b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cellular receptor for subgroup A avian leukosis and sarcoma virus (ALSV-A) is Tva, which contains a motif related to repeats in the low density lipoprotein receptor (LDLR) ligand binding repeat (LBr) and which is necessary for viral entry. As observed with LBr repeats of LDLR, the 47 residue LBr domain of Tva (sTva47) requires calcium during oxidative folding to form the correct disulfide bonds, and calcium enhances the structure of correctly oxidized sTva47, as well as its ability to bind the viral envelope protein (Env). However, solution nuclear magnetic resonance studies indicate that, even in the presence of excess calcium, sTva47 exists in an ensemble of conformations. Nonetheless, as reported here, the structure of the predominant sTva47 solution conformer closely resembles that of other LBr repeats, with identical S-S binding topology and octahedral calcium coordination. The location of W48 and other critical residues on the surface suggests a region of the molecule necessary for Env binding and to mediate post-binding events important for ALSV-A cell entry.

-	~~{{STRUCTURE_1k7b\| PDB=1k7b \| SCENE= }}~~	+	The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus.,Tonelli M, Peters RJ, James TL, Agard DA FEBS Lett. 2001 Dec 7;509(2):161-8. PMID:11768384<ref>PMID:11768384</ref>

-	~~===NMR Solution Structure~~ of ~~sTva47,~~ the ~~Viral-Binding Domain of Tva===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11768384}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1k7b]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Coturnix_coturnix Coturnix coturnix]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011768384<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Coturnix coturnix]]		[[Category: Coturnix coturnix]]
	[[Category: Agard, D A.]]		[[Category: Agard, D A.]]

OCA: Protected "1k7b" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:50:22 GMT

Protected "1k7b" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:50, 5 December 2012

OCA at 19:50, 5 December 2012

OCA — Wed, 05 Dec 2012 19:50:19 GMT

←Older revision		Revision as of 19:50, 5 December 2012
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-	{{Seed}}
	[[Image:1k7b.png\|left\|200px]]		[[Image:1k7b.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1k7b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1k7b\| PDB=1k7b \| SCENE= }}		{{STRUCTURE_1k7b\| PDB=1k7b \| SCENE= }}

	===NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva===		===NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11768384}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11768384 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11768384}}		{{ABSTRACT_PUBMED_11768384}}

	==About this Structure==		==About this Structure==
-	~~1K7B~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA].	+	[[1k7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11768384~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011768384</ref><references group="xtra"/>
	[[Category: Coturnix coturnix]]		[[Category: Coturnix coturnix]]
	[[Category: Agard, D A.]]		[[Category: Agard, D A.]]
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	[[Category: Beta hairpin]]		[[Category: Beta hairpin]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
-		+	[[Category: Membrane protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 05:46:43 2009''~~	+