1k8g - Revision history

OCA at 08:54, 16 August 2023

OCA — Wed, 16 Aug 2023 08:54:07 GMT

←Older revision		Revision as of 08:54, 16 August 2023
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	<StructureSection load='1k8g' size='340' side='right'caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1k8g' size='340' side='right'caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ciliate Ciliate~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1otc\|1otc]], [[1jb7\|1jb7]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [https://pdbe.org/1k8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [https://www.ebi.ac.uk/pdbsum/1k8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [https://pdbe.org/1k8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [https://www.ebi.ac.uk/pdbsum/1k8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~TEBA_OXYNO TEBA_OXYNO]~~] May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.	+	[https://www.uniprot.org/uniprot/TEBA_STENO TEBA_STENO] May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 1k8g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1k8g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[End-binding protein\|End-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ciliate]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Classen, S~~]]	+	[[Category: Sterkiella nova]]
-	[[Category: ~~Ruggles, J A]]~~	+	[[Category: Classen S]]
-	~~[[Category: Schultz,~~ S C]]	+	[[Category: Ruggles JA]]
-	[[Category: ~~3'-dna end binding protein~~]]	+	[[Category: Schultz SC]]
-	[[Category: ~~Dna binding protein-dna complex]]~~	+
-	~~[[Category: Ob fold]]~~	+
-	~~[[Category: Protein single strand dna interaction]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: Sequence specific ssdna binding protein]]~~	+
-	~~[[Category: Telomere]]~~	+
-	~~[[Category: Telomere end binding protein~~]]	+

OCA at 06:50, 11 August 2021

OCA — Wed, 11 Aug 2021 06:50:33 GMT

←Older revision		Revision as of 06:50, 11 August 2021
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	<StructureSection load='1k8g' size='340' side='right'caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1k8g' size='340' side='right'caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ciliate Ciliate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1K8G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ciliate Ciliate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1otc\|1otc]], [[1jb7\|1jb7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [~~http~~://pdbe.org/1k8g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1k8g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [https://pdbe.org/1k8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [https://www.ebi.ac.uk/pdbsum/1k8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TEBA_OXYNO TEBA_OXYNO]] May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.	+	[[https://www.uniprot.org/uniprot/TEBA_OXYNO TEBA_OXYNO]] May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:16, 6 November 2019

OCA — Wed, 06 Nov 2019 09:16:50 GMT

←Older revision		Revision as of 09:16, 6 November 2019
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	==Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA==		==Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA==
-	<StructureSection load='1k8g' size='340' side='right' caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1k8g' size='340' side='right'caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ciliate Ciliate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K8G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ciliate Ciliate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K8G FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Ciliate]]		[[Category: Ciliate]]
		+	[[Category: Large Structures]]
	[[Category: Classen, S]]		[[Category: Classen, S]]
	[[Category: Ruggles, J A]]		[[Category: Ruggles, J A]]

OCA at 21:26, 24 January 2018

OCA — Wed, 24 Jan 2018 21:26:40 GMT

←Older revision		Revision as of 21:26, 24 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA==		==Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA==
	<StructureSection load='1k8g' size='340' side='right' caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1k8g' size='340' side='right' caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [http://pdbe.org/1k8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [http://www.ebi.ac.uk/pdbsum/1k8g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [http://pdbe.org/1k8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [http://www.ebi.ac.uk/pdbsum/1k8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k8g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k8g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]
	[[Category: Sequence specific ssdna binding protein]]		[[Category: Sequence specific ssdna binding protein]]
-	[[Category: Telomere end binding protein]]
	[[Category: Telomere]]		[[Category: Telomere]]
		+	[[Category: Telomere end binding protein]]

OCA at 05:54, 8 February 2016

OCA — Mon, 08 Feb 2016 05:54:16 GMT

←Older revision		Revision as of 05:54, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k8g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:33, 10 September 2015

OCA — Thu, 10 Sep 2015 08:33:07 GMT

←Older revision		Revision as of 08:33, 10 September 2015
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	<StructureSection load='1k8g' size='340' side='right' caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1k8g' size='340' side='right' caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sterkiella_nova Sterkiella nova~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K8G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ciliate Ciliate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K8G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [http://www.ebi.ac.uk/pdbsum/1k8g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [http://pdbe.org/1k8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [http://www.ebi.ac.uk/pdbsum/1k8g PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1k8g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sterkiella nova~~]]	+	[[Category: Ciliate]]
	[[Category: Classen, S]]		[[Category: Classen, S]]
	[[Category: Ruggles, J A]]		[[Category: Ruggles, J A]]

OCA at 21:07, 24 December 2014

OCA — Wed, 24 Dec 2014 21:07:12 GMT

←Older revision		Revision as of 21:07, 24 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K8G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K8G FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [http://www.ebi.ac.uk/pdbsum/1k8g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [http://www.ebi.ac.uk/pdbsum/1k8g PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TEBA_OXYNO TEBA_OXYNO]] May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Sterkiella nova]]		[[Category: Sterkiella nova]]
-	[[Category: Classen, S.]]	+	[[Category: Classen, S]]
-	[[Category: Ruggles, J A.]]	+	[[Category: Ruggles, J A]]
-	[[Category: Schultz, S C.]]	+	[[Category: Schultz, S C]]
	[[Category: 3'-dna end binding protein]]		[[Category: 3'-dna end binding protein]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]

OCA at 13:19, 28 September 2014

OCA — Sun, 28 Sep 2014 13:19:33 GMT

←Older revision		Revision as of 13:19, 28 September 2014
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-	[[~~Image:~~1k8g.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA==
		+	<StructureSection load='1k8g' size='340' side='right' caption='[[1k8g]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K8G FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1otc\|1otc]], [[1jb7\|1jb7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k8g RCSB], [http://www.ebi.ac.uk/pdbsum/1k8g PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k8g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Oxytricha nova telomere end-binding protein specifically recognizes and caps single strand (T(4)G(4))(n) telomeric DNA at the very 3'-ends of O. nova macronuclear chromosomes. Proteins homologous to the N-terminal domain of OnTEBP alpha subunit have now been identified in Oxytricha trifallax, Stylonychia mytilis, Euplotes crassus, Schizosaccharomyces pombe, and Homo sapiens, suggesting that this protein is widely distributed in eukaryotes. We describe here the crystal structures of the N-terminal single-stranded DNA (ssDNA)-binding domain of O. nova telomere end-binding protein alpha subunit both uncomplexed and complexed with single strand telomeric DNA. These structures show how the N-terminal domain of alpha alone, in the absence of the beta subunit and without alpha dimerization, can bind single-stranded telomeric DNA in a sequence-specific and 3'-end-specific manner. Furthermore, comparison of the uncomplexed and complexed forms of this protein shows that the ssDNA-binding site is largely pre-organized in the absence of ssDNA with modest, but interesting, rearrangements of amino acid side-chains that compose the ssDNA-binding site. The structures described here extend our understanding of structures of O. nova telomeric complexes by adding uncomplexed and complexed forms of monomeric alpha to previously described structures for (alpha 56/ssDNA)(2) dimer and alpha 56/beta 28/ssDNA ternary complexes. We believe that each of these four structures represent intermediates in an ordered assembly/disassembly pathway for O. nova telomeric complexes.

-	~~{{STRUCTURE_1k8g\| PDB=1k8g \| SCENE= }}~~	+	Crystal structure of the N-terminal domain of Oxytricha nova telomere end-binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA.,Classen S, Ruggles JA, Schultz SC J Mol Biol. 2001 Dec 14;314(5):1113-25. PMID:11743727<ref>PMID:11743727</ref>

-	~~===Crystal Structure~~ of the ~~N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11743727}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1k8g]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sterkiella_nova Sterkiella nova]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011743727<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Sterkiella nova]]		[[Category: Sterkiella nova]]
	[[Category: Classen, S.]]		[[Category: Classen, S.]]

OCA: Protected "1k8g" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:54:46 GMT

Protected "1k8g" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:54, 5 December 2012

OCA at 19:54, 5 December 2012

OCA — Wed, 05 Dec 2012 19:54:43 GMT

←Older revision		Revision as of 19:54, 5 December 2012
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	[[Image:1k8g.png\|left\|200px]]		[[Image:1k8g.png\|left\|200px]]

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	{{STRUCTURE_1k8g\| PDB=1k8g \| SCENE= }}		{{STRUCTURE_1k8g\| PDB=1k8g \| SCENE= }}

	===Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA===		===Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA===

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	{{ABSTRACT_PUBMED_11743727}}		{{ABSTRACT_PUBMED_11743727}}

	==About this Structure==		==About this Structure==
-	~~1K8G~~ is a 5 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA].	+	[[1k8g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8G OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11743727~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011743727</ref><references group="xtra"/>
	[[Category: Sterkiella nova]]		[[Category: Sterkiella nova]]
	[[Category: Classen, S.]]		[[Category: Classen, S.]]
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	[[Category: Schultz, S C.]]		[[Category: Schultz, S C.]]
	[[Category: 3'-dna end binding protein]]		[[Category: 3'-dna end binding protein]]
		+	[[Category: Dna binding protein-dna complex]]
	[[Category: Ob fold]]		[[Category: Ob fold]]
	[[Category: Protein single strand dna interaction]]		[[Category: Protein single strand dna interaction]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]
	[[Category: Sequence specific ssdna binding protein]]		[[Category: Sequence specific ssdna binding protein]]
-	[[Category: Structure]]
	[[Category: Telomere end binding protein]]		[[Category: Telomere end binding protein]]
	[[Category: Telomere]]		[[Category: Telomere]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:35:48 2009''