1kgj - Revision history

OCA at 08:58, 16 August 2023

OCA — Wed, 16 Aug 2023 08:58:24 GMT

←Older revision		Revision as of 08:58, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FL8:6~~,~~4-DIHYDROXY-~~3~~-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [https://pdbe.org/1kgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [https://www.ebi.ac.uk/pdbsum/1kgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [https://pdbe.org/1kgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [https://www.ebi.ac.uk/pdbsum/1kgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TTHY_RAT TTHY_RAT]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:2309926</ref>	+	[https://www.uniprot.org/uniprot/TTHY_RAT TTHY_RAT] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:2309926</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Cody, V]]	+	[[Category: Cody V]]
-	[[Category: Luft~~, J R~~]]	+	[[Category: Luft JR]]
-	[[Category: Muziol, T]]	+	[[Category: Muziol T]]
-	[[Category: Neumann, P]]	+	[[Category: Neumann P]]
-	[[Category: Pangborn, W]]	+	[[Category: Pangborn W]]
-	[[Category: Wojtczak, A]]	+	[[Category: Wojtczak A]]
-	~~[[Category: Aurone]]~~	+
-	~~[[Category: Dibromoflavone]]~~	+
-	~~[[Category: Prealbumin]]~~	+
-	~~[[Category: Thyroid hormone]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:53, 11 August 2021

OCA — Wed, 11 Aug 2021 06:53:39 GMT

←Older revision		Revision as of 06:53, 11 August 2021
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	<StructureSection load='1kgj' size='340' side='right'caption='[[1kgj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1kgj' size='340' side='right'caption='[[1kgj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [~~http~~://pdbe.org/1kgj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kgj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [https://pdbe.org/1kgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [https://www.ebi.ac.uk/pdbsum/1kgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TTHY_RAT TTHY_RAT]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:2309926</ref>	+	[[https://www.uniprot.org/uniprot/TTHY_RAT TTHY_RAT]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:2309926</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Transthyretin\|Transthyretin]]	+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:22, 6 November 2019

OCA — Wed, 06 Nov 2019 09:22:08 GMT

←Older revision		Revision as of 09:22, 6 November 2019
Line 1:		Line 1:

	==Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)==		==Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)==
-	<StructureSection load='1kgj' size='340' side='right' caption='[[1kgj]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1kgj' size='340' side='right'caption='[[1kgj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1kgj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kgj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transthyretin\|Transthyretin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Cody, V]]		[[Category: Cody, V]]

OCA at 21:30, 24 January 2018

OCA — Wed, 24 Jan 2018 21:30:45 GMT

←Older revision		Revision as of 21:30, 24 January 2018
Line 1:		Line 1:
		+
	==Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)==		==Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)==
	<StructureSection load='1kgj' size='340' side='right' caption='[[1kgj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1kgj' size='340' side='right' caption='[[1kgj]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [http://pdbe.org/1kgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [http://www.ebi.ac.uk/pdbsum/1kgj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [http://pdbe.org/1kgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [http://www.ebi.ac.uk/pdbsum/1kgj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1kgj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kgj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Transthyretin\|Transthyretin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:04, 7 February 2016

OCA — Sun, 07 Feb 2016 11:04:38 GMT

←Older revision		Revision as of 11:04, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kgj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:53, 10 September 2015

OCA — Thu, 10 Sep 2015 00:53:39 GMT

←Older revision		Revision as of 00:53, 10 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [http://www.ebi.ac.uk/pdbsum/1kgj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [http://pdbe.org/1kgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [http://www.ebi.ac.uk/pdbsum/1kgj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kgj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:36, 24 December 2014

OCA — Wed, 24 Dec 2014 14:36:33 GMT

←Older revision		Revision as of 14:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [http://www.ebi.ac.uk/pdbsum/1kgj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [http://www.ebi.ac.uk/pdbsum/1kgj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TTHY_RAT TTHY_RAT]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:2309926</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Cody, V.]]	+	[[Category: Cody, V]]
-	[[Category: Luft, J R.]]	+	[[Category: Luft, J R]]
-	[[Category: Muziol, T.]]	+	[[Category: Muziol, T]]
-	[[Category: Neumann, P.]]	+	[[Category: Neumann, P]]
-	[[Category: Pangborn, W.]]	+	[[Category: Pangborn, W]]
-	[[Category: Wojtczak, A.]]	+	[[Category: Wojtczak, A]]
	[[Category: Aurone]]		[[Category: Aurone]]
	[[Category: Dibromoflavone]]		[[Category: Dibromoflavone]]

OCA at 11:58, 28 September 2014

OCA — Sun, 28 Sep 2014 11:58:12 GMT

←Older revision		Revision as of 11:58, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1kgj.~~png~~\|~~left~~\|200px]]	+	==Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)==
		+	<StructureSection load='1kgj' size='340' side='right' caption='[[1kgj]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kgj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FL8:6,4-DIHYDROXY-3-METHYL-3,5-DIBROMOFLAVONE'>FL8</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gke\|1gke]], [[2rox\|2rox]], [[1ked\|1ked]], [[1kgi\|1kgi]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgj RCSB], [http://www.ebi.ac.uk/pdbsum/1kgj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of rat transthyretin (rTTR) complex with the dibromoflavone EMD21388 was determined to 2.3 A resolution and refined to R = 0.203 and Rfree = 0.288. Two different orientations of EMD21388, which differ in the channel penetration by 1.6 A, were found in the A/C binding site of rTTR. The single ligand position observed in the BID site is intermediate between the two positions found in the A/C site. The position of the dibromoflavone in the B/D site is similar to that reported for dibromoaurone in human TTR. The bromine atoms of EMD21388 form strong interactions in the P3 and P3' pockets of rTTR. Due to the different molecular architectures of both ligands, dibromoflavone forms only one interaction with Lys-15 near the channel entrance, while direct interactions with the pair of Lys-15 were reported for dibromoaurone. The C3* methyl group of EMD21388 mediates the bridging interactions between two TTR subunits in the P2 pockets. The interactions of the O2* hydroxyl group of dibromoaurone with the Thr-119 side chain in the P3 pockets are not matched by similar interactions in EMD21388. Both these alternative interactions can explain the competitive binding of 3',5'-dibromoflavonoids to transthyretin.

-	~~{{STRUCTURE_1kgj\| PDB=1kgj \| SCENE= }}~~	+	Comparison of binding interactions of dibromoflavonoids with transthyretin.,Muziol T, Cody V, Wojtczak A Acta Biochim Pol. 2001;48(4):885-92. PMID:11995999<ref>PMID:11995999</ref>

-	~~===Rat transthyretin (also called prealbumin) complex with 3'~~,~~5'-dibromoflavone (EMD21388)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11995999}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1kgj]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA].~~	+

	==See Also==		==See Also==
	*[[Transthyretin\|Transthyretin]]		*[[Transthyretin\|Transthyretin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011995999<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Cody, V.]]		[[Category: Cody, V.]]

OCA at 06:26, 20 October 2012

OCA — Sat, 20 Oct 2012 06:26:35 GMT

←Older revision		Revision as of 06:26, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1kgj]] is a 4 chain structure ~~of [[Transthyretin]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA].	+	[[1kgj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGJ OCA].

	==See Also==		==See Also==

OCA: Protected "1kgj" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 13:12:20 GMT

Protected "1kgj" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:12, 25 July 2012