1kgy - Revision history

OCA at 08:00, 3 April 2024

OCA — Wed, 03 Apr 2024 08:00:29 GMT

←Older revision		Revision as of 08:00, 3 April 2024
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	<StructureSection load='1kgy' size='340' side='right'caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1kgy' size='340' side='right'caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1KGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KGY FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~http://en.wikipedia.org/wiki/Transferase Transferase~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.7~~.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [~~http~~://pdbe.org/1kgy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kgy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [https://pdbe.org/1kgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [https://www.ebi.ac.uk/pdbsum/1kgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/EPHB2_MOUSE EPHB2_MOUSE]] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.<ref>PMID:8689685</ref> <ref>PMID:8947026</ref> <ref>PMID:9990854</ref> <ref>PMID:10839360</ref> <ref>PMID:14691139</ref> <ref>PMID:15223334</ref> <ref>PMID:21029865</ref> [[http://www.uniprot.org/uniprot/EFNB2_MOUSE EFNB2_MOUSE]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.	+	[https://www.uniprot.org/uniprot/EFNB2_MOUSE EFNB2_MOUSE] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kgy ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kgy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Eph family of receptor tyrosine kinases and their membrane-anchored ephrin ligands are important in regulating cell-cell interactions as they initiate a unique bidirectional signal transduction cascade whereby information is communicated into both the Eph-expressing and the ephrin-expressing cells. Initially identified as regulators of axon pathfinding and neuronal cell migration, Ephs and ephrins are now known to have roles in many other cell-cell interactions, including those of vascular endothelial cells and specialized epithelia. Here we report the crystal structure of the complex formed between EphB2 and ephrin-B2, determined at 2.7 A resolution. Each Eph receptor binds an ephrin ligand through an expansive dimerization interface dominated by the insertion of an extended ephrin loop into a channel at the surface of the receptor. Two Eph-Ephrin dimers then join to form a tetramer, in which each ligand interacts with two receptors and each receptor interacts with two ligands. The Eph and ephrin molecules are precisely positioned and orientated in these complexes, promoting higher-order clustering and the initiation of bidirectional signalling.
-
-	Crystal structure of an Eph receptor-ephrin complex.,Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB Nature. 2001 Dec 20-27;414(6866):933-8. PMID:11780069<ref>PMID:11780069</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1kgy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ephrin\|Ephrin]]		*[[Ephrin\|Ephrin]]
	*[[Ephrin receptor 3D structures\|Ephrin receptor 3D structures]]		*[[Ephrin receptor 3D structures\|Ephrin receptor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Transferase~~]]	+	[[Category: Cowan CA]]
-	[[Category: Cowan~~, C A~~]]	+	[[Category: Henkemeyer M]]
-	[[Category: Henkemeyer, M]]	+	[[Category: Himanen JP]]
-	[[Category: Himanen~~, J P~~]]	+	[[Category: Lackmann M]]
-	[[Category: Lackmann, M]]	+	[[Category: Nikolov DB]]
-	[[Category: Nikolov~~, D B~~]]	+	[[Category: Rajashankar KR]]
-	[[Category: Rajashankar~~, K R]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Transferase-transferase receptor complex~~]]	+

OCA at 10:36, 16 September 2020

OCA — Wed, 16 Sep 2020 10:36:35 GMT

←Older revision		Revision as of 10:36, 16 September 2020
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	==Crystal Structure of the EphB2-ephrinB2 complex==		==Crystal Structure of the EphB2-ephrinB2 complex==
-	<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1kgy' size='340' side='right'caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KGY FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://pdbe.org/1kgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://pdbe.org/1kgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Ephrin\|Ephrin]]		*[[Ephrin\|Ephrin]]
-	*[[Ephrin receptor\|Ephrin receptor]]	+	*[[Ephrin receptor 3D structures\|Ephrin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:36, 12 December 2018

OCA — Wed, 12 Dec 2018 07:36:01 GMT

←Older revision		Revision as of 07:36, 12 December 2018
Line 3:		Line 3:
	<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://pdbe.org/1kgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://pdbe.org/1kgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgy ProSAT]</span></td></tr>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Cowan, C A]]		[[Category: Cowan, C A]]

OCA at 06:39, 9 March 2017

OCA — Thu, 09 Mar 2017 06:39:00 GMT

←Older revision		Revision as of 06:39, 9 March 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the EphB2-ephrinB2 complex==		==Crystal Structure of the EphB2-ephrinB2 complex==
	<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://pdbe.org/1kgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://pdbe.org/1kgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lk3 transgenic mice]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Cowan, C A]]		[[Category: Cowan, C A]]
	[[Category: Henkemeyer, M]]		[[Category: Henkemeyer, M]]
-	[[Category: Himanen, J-P]]	+	[[Category: Himanen, J P]]
	[[Category: Lackmann, M]]		[[Category: Lackmann, M]]
	[[Category: Nikolov, D B]]		[[Category: Nikolov, D B]]

OCA at 12:26, 8 February 2016

OCA — Mon, 08 Feb 2016 12:26:29 GMT

←Older revision		Revision as of 12:26, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kgy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:33, 10 September 2015

OCA — Thu, 10 Sep 2015 11:33:53 GMT

←Older revision		Revision as of 11:33, 10 September 2015
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	<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://pdbe.org/1kgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kgy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Cowan, C A]]		[[Category: Cowan, C A]]

OCA at 23:18, 24 December 2014

OCA — Wed, 24 Dec 2014 23:18:37 GMT

←Older revision		Revision as of 23:18, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EPHB2_MOUSE EPHB2_MOUSE]] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.<ref>PMID:8689685</ref> <ref>PMID:8947026</ref> <ref>PMID:9990854</ref> <ref>PMID:10839360</ref> <ref>PMID:14691139</ref> <ref>PMID:15223334</ref> <ref>PMID:21029865</ref> [[http://www.uniprot.org/uniprot/EFNB2_MOUSE EFNB2_MOUSE]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	[[Category: Cowan, C A.]]	+	[[Category: Cowan, C A]]
-	[[Category: Henkemeyer, M.]]	+	[[Category: Henkemeyer, M]]
-	[[Category: Himanen, J-P.]]	+	[[Category: Himanen, J-P]]
-	[[Category: Lackmann, M.]]	+	[[Category: Lackmann, M]]
-	[[Category: Nikolov, D B.]]	+	[[Category: Nikolov, D B]]
-	[[Category: Rajashankar, K R.]]	+	[[Category: Rajashankar, K R]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Transferase-transferase receptor complex]]		[[Category: Transferase-transferase receptor complex]]

OCA at 09:12, 3 October 2014

OCA — Fri, 03 Oct 2014 09:12:03 GMT

←Older revision		Revision as of 09:12, 3 October 2014
Line 1:		Line 1:
-	[[~~Image~~:1kgy.~~png\|left~~\|200px]]	+	==Crystal Structure of the EphB2-ephrinB2 complex==
		+	<StructureSection load='1kgy' size='340' side='right' caption='[[1kgy]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgy RCSB], [http://www.ebi.ac.uk/pdbsum/1kgy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Eph family of receptor tyrosine kinases and their membrane-anchored ephrin ligands are important in regulating cell-cell interactions as they initiate a unique bidirectional signal transduction cascade whereby information is communicated into both the Eph-expressing and the ephrin-expressing cells. Initially identified as regulators of axon pathfinding and neuronal cell migration, Ephs and ephrins are now known to have roles in many other cell-cell interactions, including those of vascular endothelial cells and specialized epithelia. Here we report the crystal structure of the complex formed between EphB2 and ephrin-B2, determined at 2.7 A resolution. Each Eph receptor binds an ephrin ligand through an expansive dimerization interface dominated by the insertion of an extended ephrin loop into a channel at the surface of the receptor. Two Eph-Ephrin dimers then join to form a tetramer, in which each ligand interacts with two receptors and each receptor interacts with two ligands. The Eph and ephrin molecules are precisely positioned and orientated in these complexes, promoting higher-order clustering and the initiation of bidirectional signalling.

-	~~{{STRUCTURE_1kgy\| PDB=1kgy \| SCENE= }}~~	+	Crystal structure of an Eph receptor-ephrin complex.,Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB Nature. 2001 Dec 20-27;414(6866):933-8. PMID:11780069<ref>PMID:11780069</ref>

-	~~===Crystal Structure~~ of the ~~EphB2-ephrinB2 complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11780069}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1kgy]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA].~~	+

	==See Also==		==See Also==
		+	*[[Ephrin\|Ephrin]]
	*[[Ephrin receptor\|Ephrin receptor]]		*[[Ephrin receptor\|Ephrin receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011780069<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:08, 20 October 2012

OCA — Sat, 20 Oct 2012 10:08:04 GMT

←Older revision		Revision as of 10:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1kgy]] is a 8 chain structure ~~of [[Ephrin receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA].	+	[[1kgy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGY OCA].

	==See Also==		==See Also==

OCA: Protected "1kgy" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 01:05:32 GMT

Protected "1kgy" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:05, 26 July 2012