1kj3 - Revision history

OCA at 08:59, 16 August 2023

OCA — Wed, 16 Aug 2023 08:59:21 GMT

←Older revision		Revision as of 08:59, 16 August 2023
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	<StructureSection load='1kj3' size='340' side='right'caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1kj3' size='340' side='right'caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1vac~~\|~~1vac~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [https://pdbe.org/1kj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [https://www.ebi.ac.uk/pdbsum/1kj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kj3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [https://pdbe.org/1kj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [https://www.ebi.ac.uk/pdbsum/1kj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kj3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[https://www.uniprot.org/uniprot/GTPB1_MOUSE GTPB1_MOUSE]] Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).	+	[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Darnault, C]]	+	[[Category: Darnault C]]
-	[[Category: Fontecilla-Camps~~, J C~~]]	+	[[Category: Fontecilla-Camps JC]]
-	[[Category: Gregoire, C]]	+	[[Category: Gregoire C]]
-	[[Category: Guimezanes, A]]	+	[[Category: Guimezanes A]]
-	[[Category: Housset, D]]	+	[[Category: Housset D]]
-	[[Category: Malissen, B]]	+	[[Category: Malissen B]]
-	[[Category: Mazza, G]]	+	[[Category: Mazza G]]
-	[[Category: Mosser, T]]	+	[[Category: Mosser T]]
-	[[Category: Reiser, J B]]	+	[[Category: Reiser J-B]]
-	[[Category: Schmitt-Verhulst, A M]]	+	[[Category: Schmitt-Verhulst A-M]]
-	~~[[Category: Allogeneic]]~~	+
-	~~[[Category: H-2kb]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mhc class i]]~~	+
-	~~[[Category: Pmhc complex~~]]	+

OCA at 06:54, 11 August 2021

OCA — Wed, 11 Aug 2021 06:54:06 GMT

←Older revision		Revision as of 06:54, 11 August 2021
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	<StructureSection load='1kj3' size='340' side='right'caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1kj3' size='340' side='right'caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vac\|1vac]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [~~http~~://pdbe.org/1kj3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kj3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kj3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [https://pdbe.org/1kj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [https://www.ebi.ac.uk/pdbsum/1kj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kj3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[~~http~~://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[~~http~~://www.uniprot.org/uniprot/GTPB1_MOUSE GTPB1_MOUSE]] Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).	+	[[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[https://www.uniprot.org/uniprot/GTPB1_MOUSE GTPB1_MOUSE]] Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:24, 6 November 2019

OCA — Wed, 06 Nov 2019 09:24:28 GMT

←Older revision		Revision as of 09:24, 6 November 2019
Line 1:		Line 1:

	==Mhc Class I H-2Kb molecule complexed with pKB1 peptide==		==Mhc Class I H-2Kb molecule complexed with pKB1 peptide==
-	<StructureSection load='1kj3' size='340' side='right' caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1kj3' size='340' side='right'caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1kj3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kj3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Darnault, C]]		[[Category: Darnault, C]]

OCA at 21:32, 24 January 2018

OCA — Wed, 24 Jan 2018 21:32:25 GMT

←Older revision		Revision as of 21:32, 24 January 2018
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		+
	==Mhc Class I H-2Kb molecule complexed with pKB1 peptide==		==Mhc Class I H-2Kb molecule complexed with pKB1 peptide==
	<StructureSection load='1kj3' size='340' side='right' caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1kj3' size='340' side='right' caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [http://pdbe.org/1kj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kj3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [http://pdbe.org/1kj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kj3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kj3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/1kj3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/1kj3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1kj3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kj3" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:53, 10 February 2016

OCA — Wed, 10 Feb 2016 04:53:42 GMT

←Older revision		Revision as of 04:53, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kj3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:34, 11 September 2015

OCA — Fri, 11 Sep 2015 05:34:39 GMT

←Older revision		Revision as of 05:34, 11 September 2015
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	<StructureSection load='1kj3' size='340' side='right' caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1kj3' size='340' side='right' caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kj3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [http://pdbe.org/1kj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kj3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kj3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Darnault, C]]		[[Category: Darnault, C]]
	[[Category: Fontecilla-Camps, J C]]		[[Category: Fontecilla-Camps, J C]]

OCA at 11:54, 25 December 2014

OCA — Thu, 25 Dec 2014 11:54:57 GMT

←Older revision		Revision as of 11:54, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kj3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kj3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/GTPB1_MOUSE GTPB1_MOUSE]] Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Darnault, C.]]	+	[[Category: Darnault, C]]
-	[[Category: Fontecilla-Camps, J C.]]	+	[[Category: Fontecilla-Camps, J C]]
-	[[Category: Gregoire, C.]]	+	[[Category: Gregoire, C]]
-	[[Category: Guimezanes, A.]]	+	[[Category: Guimezanes, A]]
-	[[Category: Housset, D.]]	+	[[Category: Housset, D]]
-	[[Category: Malissen, B.]]	+	[[Category: Malissen, B]]
-	[[Category: Mazza, G.]]	+	[[Category: Mazza, G]]
-	[[Category: Mosser, T.]]	+	[[Category: Mosser, T]]
-	[[Category: Reiser, J B.]]	+	[[Category: Reiser, J B]]
-	[[Category: Schmitt-Verhulst, A M.]]	+	[[Category: Schmitt-Verhulst, A M]]
	[[Category: Allogeneic]]		[[Category: Allogeneic]]
	[[Category: H-2kb]]		[[Category: H-2kb]]

OCA at 09:27, 28 September 2014

OCA — Sun, 28 Sep 2014 09:27:42 GMT

←Older revision		Revision as of 09:27, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1kj3.~~png~~\|~~left~~\|200px]]	+	==Mhc Class I H-2Kb molecule complexed with pKB1 peptide==
		+	<StructureSection load='1kj3' size='340' side='right' caption='[[1kj3]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vac\|1vac]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kj3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kj3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/1kj3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR and an octapeptide bound to the allogeneic H-2K(b) MHC class I molecule. This structure reveals how a tremendously large CDR3beta conformational change allows the KB5-C20 TCR to adapt to the rather constrained pMHC surface and achieve a diagonal docking mode. This extreme case of induced fit also shows that TCR plasticity is primarily restricted to CDR3 loops and does not propagate away from the antigen binding site.

-	~~{{STRUCTURE_1kj3\| PDB=1kj3 \| SCENE= }}~~	+	A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.,Reiser JB, Gregoire C, Darnault C, Mosser T, Guimezanes A, Schmitt-Verhulst AM, Fontecilla-Camps JC, Mazza G, Malissen B, Housset D Immunity. 2002 Mar;16(3):345-54. PMID:11911820<ref>PMID:11911820</ref>

-	~~===Mhc Class I H-2Kb molecule complexed with pKB1 peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11911820}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1kj3]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011911820<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Darnault, C.]]		[[Category: Darnault, C.]]

OCA at 16:23, 20 October 2012

OCA — Sat, 20 Oct 2012 16:23:49 GMT

←Older revision		Revision as of 16:23, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1kj3]] is a 6 chain structure ~~of [[Beta-2 microglobulin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA].	+	[[1kj3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA].

	==See Also==		==See Also==

OCA: Protected "1kj3" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 21:32:40 GMT

Protected "1kj3" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:32, 26 July 2012