1kk3 - Revision history

OCA at 08:59, 16 August 2023

OCA — Wed, 16 Aug 2023 08:59:47 GMT

←Older revision		Revision as of 08:59, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1kk3' size='340' side='right'caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1kk3' size='340' side='right'caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus~~ abyssi~~" erauso et al. 1993~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [https://pdbe.org/1kk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [https://www.ebi.ac.uk/pdbsum/1kk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kk3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [https://pdbe.org/1kk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [https://www.ebi.ac.uk/pdbsum/1kk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kk3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IF2G_PYRAB IF2G_PYRAB]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).	+	[https://www.uniprot.org/uniprot/IF2G_PYRAB IF2G_PYRAB] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pyrococcus abyssi erauso et al. 1993]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Blanquet, S~~]]	+	[[Category: Pyrococcus abyssi]]
-	[[Category: ~~Mechulam, Y~~]]	+	[[Category: Blanquet S]]
-	[[Category: ~~Schmitt, E~~]]	+	[[Category: Mechulam Y]]
-	[[Category: ~~Initiation of translation]]~~	+	[[Category: Schmitt E]]
-	~~[[Category: Translation~~]]	+

OCA at 06:54, 11 August 2021

OCA — Wed, 11 Aug 2021 06:54:38 GMT

←Older revision		Revision as of 06:54, 11 August 2021
Line 3:		Line 3:
	<StructureSection load='1kk3' size='340' side='right'caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1kk3' size='340' side='right'caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [~~http~~://pdbe.org/1kk3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kk3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kk3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [https://pdbe.org/1kk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [https://www.ebi.ac.uk/pdbsum/1kk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kk3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IF2G_PYRAB IF2G_PYRAB]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).	+	[[https://www.uniprot.org/uniprot/IF2G_PYRAB IF2G_PYRAB]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:17, 6 November 2019

OCA — Wed, 06 Nov 2019 09:17:30 GMT

←Older revision		Revision as of 09:17, 6 November 2019
Line 1:		Line 1:

	==Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+==		==Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+==
-	<StructureSection load='1kk3' size='340' side='right' caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1kk3' size='340' side='right'caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Pyrococcus abyssi erauso et al. 1993]]		[[Category: Pyrococcus abyssi erauso et al. 1993]]
		+	[[Category: Large Structures]]
	[[Category: Blanquet, S]]		[[Category: Blanquet, S]]
	[[Category: Mechulam, Y]]		[[Category: Mechulam, Y]]

OCA at 21:27, 24 January 2018

OCA — Wed, 24 Jan 2018 21:27:05 GMT

←Older revision		Revision as of 21:27, 24 January 2018
Line 1:		Line 1:
		+
	==Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+==		==Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+==
	<StructureSection load='1kk3' size='340' side='right' caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1kk3' size='340' side='right' caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [http://pdbe.org/1kk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kk3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [http://pdbe.org/1kk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kk3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kk3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kk3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:40, 8 February 2016

OCA — Mon, 08 Feb 2016 07:40:19 GMT

←Older revision		Revision as of 07:40, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kk3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:20, 10 September 2015

OCA — Thu, 10 Sep 2015 09:20:43 GMT

←Older revision		Revision as of 09:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1kk3' size='340' side='right' caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1kk3' size='340' side='right' caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_abyssi Pyrococcus~~ abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kk3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [http://pdbe.org/1kk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kk3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kk3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pyrococcus abyssi]]	+	[[Category: Pyrococcus abyssi erauso et al. 1993]]
	[[Category: Blanquet, S]]		[[Category: Blanquet, S]]
	[[Category: Mechulam, Y]]		[[Category: Mechulam, Y]]

OCA at 21:42, 24 December 2014

OCA — Wed, 24 Dec 2014 21:42:32 GMT

←Older revision		Revision as of 21:42, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kk3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kk3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IF2G_PYRAB IF2G_PYRAB]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Pyrococcus abyssi]]		[[Category: Pyrococcus abyssi]]
-	[[Category: Blanquet, S.]]	+	[[Category: Blanquet, S]]
-	[[Category: Mechulam, Y.]]	+	[[Category: Mechulam, Y]]
-	[[Category: Schmitt, E.]]	+	[[Category: Schmitt, E]]
	[[Category: Initiation of translation]]		[[Category: Initiation of translation]]
	[[Category: Translation]]		[[Category: Translation]]

OCA at 14:10, 28 September 2014

OCA — Sun, 28 Sep 2014 14:10:12 GMT

←Older revision		Revision as of 14:10, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1kk3.~~png~~\|~~left~~\|200px]]	+	==Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+==
		+	<StructureSection load='1kk3' size='340' side='right' caption='[[1kk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KK3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kjz\|1kjz]], [[1kk0\|1kk0]], [[1kk1\|1kk1]], [[1kk2\|1kk2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kk3 RCSB], [http://www.ebi.ac.uk/pdbsum/1kk3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kk3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The heterotrimeric factor e/aIF2 plays a central role in eukaryotic/archaeal initiation of translation. By delivering the initiator methionyl-tRNA to the ribosome, e/aIF2 ensures specificity of initiation codon selection. The three subunits of aIF2 from the hyperthermophilic archaeon Pyrococcus abyssi could be overproduced in Escherichia coli. The beta and gamma subunits each contain a tightly bound zinc. The large gamma subunit is shown to form the structural core for trimer assembly. The crystal structures of aIF2gamma, free or complexed to GDP-Mg(2+) or GDPNP-Mg(2+), were resolved at resolutions better than 2 A. aIF2gamma displays marked similarities to elongation factors. A distinctive feature of e/aIF2gamma is a subdomain containing a zinc-binding knuckle. Examination of the nucleotide-complexed aIF2gamma structures suggests mechanisms of action and tRNA binding properties similar to those of an elongation factor. Implications for the mechanism of translation initiation in both eukarya and archaea are discussed. In particular, positioning of the initiator tRNA in the ribosomal A site during the search for the initiation codon is envisaged.

-	~~{{STRUCTURE_1kk3\| PDB=1kk3 \| SCENE= }}~~	+	The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.,Schmitt E, Blanquet S, Mechulam Y EMBO J. 2002 Apr 2;21(7):1821-32. PMID:11927566<ref>PMID:11927566</ref>

-	~~===Structure~~ of the ~~wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11927566}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1kk3]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011927566<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pyrococcus abyssi]]		[[Category: Pyrococcus abyssi]]
	[[Category: Blanquet, S.]]		[[Category: Blanquet, S.]]

OCA: Protected "1kk3" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:55:07 GMT

Protected "1kk3" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:55, 5 December 2012

OCA at 20:55, 5 December 2012

OCA — Wed, 05 Dec 2012 20:55:04 GMT

←Older revision		Revision as of 20:55, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1kk3.png\|left\|200px]]		[[Image:1kk3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1kk3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1kk3\| PDB=1kk3 \| SCENE= }}		{{STRUCTURE_1kk3\| PDB=1kk3 \| SCENE= }}

	===Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+===		===Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11927566}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11927566 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11927566}}		{{ABSTRACT_PUBMED_11927566}}

	==About this Structure==		==About this Structure==
-	~~1KK3~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA].	+	[[1kk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KK3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11927566~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011927566</ref><references group="xtra"/>
	[[Category: Pyrococcus abyssi]]		[[Category: Pyrococcus abyssi]]
	[[Category: Blanquet, S.]]		[[Category: Blanquet, S.]]
Line 29:		Line 17:
	[[Category: Schmitt, E.]]		[[Category: Schmitt, E.]]
	[[Category: Initiation of translation]]		[[Category: Initiation of translation]]
-		+	[[Category: Translation]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 20:16:19 2009''~~	+