1kkq - Revision history

OCA at 09:00, 16 August 2023

OCA — Wed, 16 Aug 2023 09:00:10 GMT

←Older revision		Revision as of 09:00, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1kkq' size='340' side='right'caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1kkq' size='340' side='right'caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k7l\|1k7l]], [[1k74\|1k74]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [https://pdbe.org/1kkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [https://www.ebi.ac.uk/pdbsum/1kkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [~~http~~://pdbe.org/1kkq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kkq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~NCOR2_HUMAN NCOR2_HUMAN~~]~~] Transcriptional corepressor~~ of ~~NR4A2/NURR1 and acts through histone deacetylases~~ (~~HDACs) to keep promoters of NR4A2~~/~~NURR1 target genes in~~ a ~~repressed deacetylated state~~ (By similarity). ~~Mediates~~ the ~~transcriptional repression activity~~ of ~~some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal~~ transcription. ~~Isoform 1~~ and ~~isoform 5 have different affinities for different nuclear receptors~~.	+	[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cobb~~, J E~~]]	+	[[Category: Cobb JE]]
-	[[Category: Galardi~~, C M~~]]	+	[[Category: Galardi CM]]
-	[[Category: Lambert~~, M H~~]]	+	[[Category: Lambert MH]]
-	[[Category: McKee~~, D D~~]]	+	[[Category: McKee DD]]
-	[[Category: Montana~~, V G~~]]	+	[[Category: Montana VG]]
-	[[Category: Nolte~~, R T~~]]	+	[[Category: Nolte RT]]
-	[[Category: Parks~~, D J~~]]	+	[[Category: Parks DJ]]
-	[[Category: Shearer~~, B G~~]]	+	[[Category: Shearer BG]]
-	[[Category: Stanley~~, T B~~]]	+	[[Category: Stanley TB]]
-	[[Category: Xu~~, H E]]~~	+	[[Category: Xu HE]]
-	~~[[Category: Nuclear corepressor nuclear hormone receptors antagonist]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:46, 25 November 2020

OCA — Wed, 25 Nov 2020 07:46:31 GMT

←Older revision		Revision as of 07:46, 25 November 2020
Line 1:		Line 1:

	==Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif==		==Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif==
-	<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1kkq' size='340' side='right'caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k7l\|1k7l]], [[1k74\|1k74]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://pdbe.org/1kkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://pdbe.org/1kkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kkq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kkq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nuclear receptor corepressor\|Nuclear receptor corepressor]]
		+	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
		+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cobb, J E]]		[[Category: Cobb, J E]]
	[[Category: Galardi, C M]]		[[Category: Galardi, C M]]

OCA at 08:17, 12 October 2017

OCA — Thu, 12 Oct 2017 08:17:09 GMT

←Older revision		Revision as of 08:17, 12 October 2017
Line 3:		Line 3:
	<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://pdbe.org/1kkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://pdbe.org/1kkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkq ProSAT]</span></td></tr>
	</table>		</table>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Cobb, J E]]		[[Category: Cobb, J E]]
	[[Category: Galardi, C M]]		[[Category: Galardi, C M]]

OCA at 01:22, 10 March 2017

OCA — Fri, 10 Mar 2017 01:22:56 GMT

←Older revision		Revision as of 01:22, 10 March 2017
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:01, 1 February 2017

OCA — Wed, 01 Feb 2017 11:01:30 GMT

←Older revision		Revision as of 11:01, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif==		==Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif==
	<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://pdbe.org/1kkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://pdbe.org/1kkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Cobb, J E]]		[[Category: Cobb, J E]]
	[[Category: Galardi, C M]]		[[Category: Galardi, C M]]

OCA at 02:45, 10 February 2016

OCA — Wed, 10 Feb 2016 02:45:15 GMT

←Older revision		Revision as of 02:45, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kkq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:36, 11 September 2015

OCA — Fri, 11 Sep 2015 04:36:04 GMT

←Older revision		Revision as of 04:36, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://pdbe.org/1kkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kkq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cobb, J E]]		[[Category: Cobb, J E]]
	[[Category: Galardi, C M]]		[[Category: Galardi, C M]]

OCA at 11:14, 25 December 2014

OCA — Thu, 25 Dec 2014 11:14:37 GMT

←Older revision		Revision as of 11:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cobb, J E.]]	+	[[Category: Cobb, J E]]
-	[[Category: Galardi, C M.]]	+	[[Category: Galardi, C M]]
-	[[Category: Lambert, M H.]]	+	[[Category: Lambert, M H]]
-	[[Category: McKee, D D.]]	+	[[Category: McKee, D D]]
-	[[Category: Montana, V G.]]	+	[[Category: Montana, V G]]
-	[[Category: Nolte, R T.]]	+	[[Category: Nolte, R T]]
-	[[Category: Parks, D J.]]	+	[[Category: Parks, D J]]
	[[Category: Shearer, B G]]		[[Category: Shearer, B G]]
-	[[Category: Stanley, T B.]]	+	[[Category: Stanley, T B]]
-	[[Category: Xu, H E.]]	+	[[Category: Xu, H E]]
	[[Category: Nuclear corepressor nuclear hormone receptors antagonist]]		[[Category: Nuclear corepressor nuclear hormone receptors antagonist]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 04:09, 3 October 2014

OCA — Fri, 03 Oct 2014 04:09:02 GMT

←Older revision		Revision as of 04:09, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1kkq\| PDB=1kkq \| SCENE= }}~~	+	==Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif==
-	===Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif===	+	<StructureSection load='1kkq' size='340' side='right' caption='[[1kkq]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	{{~~ABSTRACT_PUBMED_11845213}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k7l\|1k7l]], [[1k74\|1k74]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kkq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Repression of gene transcription by nuclear receptors is mediated by interactions with co-repressor proteins such as SMRT and N-CoR, which in turn recruit histone deacetylases to the chromatin. Aberrant interactions between nuclear receptors and co-repressors contribute towards acute promyelocytic leukaemia and thyroid hormone resistance syndrome. The binding of co-repressors to nuclear receptors occurs in the unliganded state, and can be stabilized by antagonists. Here we report the crystal structure of a ternary complex containing the peroxisome proliferator-activated receptor-alpha ligand-binding domain bound to the antagonist GW6471 and a SMRT co-repressor motif. In this structure, the co-repressor motif adopts a three-turn alpha-helix that prevents the carboxy-terminal activation helix (AF-2) of the receptor from assuming the active conformation. Binding of the co-repressor motif is further reinforced by the antagonist, which blocks the AF-2 helix from adopting the active position. Biochemical analyses and structure-based mutagenesis indicate that this mode of co-repressor binding is highly conserved across nuclear receptors.

-	~~==Function==~~	+	Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.,Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, Stimmel JB Nature. 2002 Feb 14;415(6873):813-7. PMID:11845213<ref>PMID:11845213</ref>
-	~~[[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor~~ of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear ~~receptors~~ by ~~promoting chromatin condensation~~, ~~thus preventing access of the basal transcription~~. ~~Isoform 1 and isoform 5 have different affinities for different nuclear receptors~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1kkq]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]		*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:011845213</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cobb, J E.]]		[[Category: Cobb, J E.]]

OCA at 03:05, 20 September 2013

OCA — Fri, 20 Sep 2013 03:05:26 GMT

←Older revision		Revision as of 03:05, 20 September 2013
Line 1:		Line 1:
-	[[Image:1kkq.png\|left\|200px]]
-
	{{STRUCTURE_1kkq\| PDB=1kkq \| SCENE= }}		{{STRUCTURE_1kkq\| PDB=1kkq \| SCENE= }}
-
	===Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif===		===Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif===
		+	{{ABSTRACT_PUBMED_11845213}}

-	~~{{ABSTRACT_PUBMED_11845213}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011845213</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011845213</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cobb, J E.]]		[[Category: Cobb, J E.]]