1kl0 - Revision history

OCA at 06:54, 11 August 2021

OCA — Wed, 11 Aug 2021 06:54:52 GMT

←Older revision		Revision as of 06:54, 11 August 2021
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	<StructureSection load='1kl0' size='340' side='right'caption='[[1kl0]]' scene=''>		<StructureSection load='1kl0' size='340' side='right'caption='[[1kl0]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kl0 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1kl0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kl0 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kl0 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1kl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kl0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:28, 6 November 2019

OCA — Wed, 06 Nov 2019 09:28:08 GMT

←Older revision		Revision as of 09:28, 6 November 2019
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	==THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF==		==THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF==
-	<StructureSection load='1kl0' size='340' side='right' caption='[[1kl0]]' scene=''>	+	<StructureSection load='1kl0' size='340' side='right'caption='[[1kl0]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Hayashi, I]]		[[Category: Hayashi, I]]
	[[Category: Liddington, R C]]		[[Category: Liddington, R C]]
	[[Category: Vuori, K]]		[[Category: Vuori, K]]

OCA at 21:35, 24 January 2018

OCA — Wed, 24 Jan 2018 21:35:08 GMT

←Older revision		Revision as of 21:35, 24 January 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kl0 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1kl0 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kl0 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1kl0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kl0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:11, 11 February 2016

OCA — Thu, 11 Feb 2016 09:11:00 GMT

←Older revision		Revision as of 09:11, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF==		==THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF==
	<StructureSection load='1kl0' size='340' side='right' caption='[[1kl0]]' scene=''>		<StructureSection load='1kl0' size='340' side='right' caption='[[1kl0]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Hayashi, I]]		[[Category: Hayashi, I]]
	[[Category: Liddington, R C]]		[[Category: Liddington, R C]]
	[[Category: Vuori, K]]		[[Category: Vuori, K]]

OCA at 16:10, 11 September 2015

OCA — Fri, 11 Sep 2015 16:10:48 GMT

←Older revision		Revision as of 16:10, 11 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kl0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:49, 5 January 2015

OCA — Mon, 05 Jan 2015 16:49:22 GMT

←Older revision		Revision as of 16:49, 5 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kl0 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1kl0 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kl0 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1kl0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:20, 28 September 2014

OCA — Sun, 28 Sep 2014 14:20:16 GMT

←Older revision		Revision as of 14:20, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF==
		+	<StructureSection load='1kl0' size='340' side='right' caption='[[1kl0]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kl0 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1kl0 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. We have determined the crystal structure of FAT and show that it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. We show by mutagenesis that paxillin binding involves two hydrophobic patches on opposite faces of the bundle and propose a model in which two LD motifs of paxillin adopt amphipathic helices that augment the hydrophobic core of FAT, creating a six-helix bundle.

-	~~[[Image~~:~~1kl0~~.~~png\|left\|200px]]~~	+	The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin.,Hayashi I, Vuori K, Liddington RC Nat Struct Biol. 2002 Feb;9(2):101-6. PMID:11799401<ref>PMID:11799401</ref>

-	~~{{STRUCTURE_1kl0\| PDB=1kl0 \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_11799401}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:011799401<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Hayashi, I]]		[[Category: Hayashi, I]]
	[[Category: Liddington, R C]]		[[Category: Liddington, R C]]
	[[Category: Vuori, K]]		[[Category: Vuori, K]]

OCA: Protected "1kl0" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:48:52 GMT

Protected "1kl0" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:48, 21 October 2012

OCA at 09:48, 21 October 2012

OCA — Sun, 21 Oct 2012 09:48:49 GMT

←Older revision		Revision as of 09:48, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1kl0.png\|left\|200px]]		[[Image:1kl0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1kl0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1kl0\| PDB=1kl0 \| SCENE= }}		{{STRUCTURE_1kl0\| PDB=1kl0 \| SCENE= }}

	===THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF===		===THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11799401}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11799401 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11799401}}		{{ABSTRACT_PUBMED_11799401}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KL0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11799401~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011799401</ref><references group="xtra"/>
	[[Category: Hayashi, I]]		[[Category: Hayashi, I]]
	[[Category: Liddington, R C]]		[[Category: Liddington, R C]]
	[[Category: Vuori, K]]		[[Category: Vuori, K]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:01:11 2010''

OCA at 06:01, 8 April 2010

OCA — Thu, 08 Apr 2010 06:01:11 GMT

←Older revision		Revision as of 06:01, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1kl0.png\|left\|200px]]

-	The ~~entry 1KL0~~ is ~~a Theoretical Model titled 'THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1kl0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1kl0\| PDB=1kl0 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===THEORETICAL MODEL OF THE FAT DOMAIN OF FOCAL ADHESION KINASE COMPLEXED WITH PAXILLIN LD2 MOTIF===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30~~ 09:50:~~39 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_11799401}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11799401 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11799401}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KL0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:11799401</ref><references group="xtra"/>
		+	[[Category: Hayashi, I]]
		+	[[Category: Liddington, R C]]
		+	[[Category: Vuori, K]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:01:11 2010''