1klx - Revision history

OCA at 08:01, 3 April 2024

OCA — Wed, 03 Apr 2024 08:01:53 GMT

←Older revision		Revision as of 08:01, 3 April 2024
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	<StructureSection load='1klx' size='340' side='right'caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1klx' size='340' side='right'caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43504 Atcc 43504~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HP0336 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=210 ATCC 43504])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [https://pdbe.org/1klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [https://www.ebi.ac.uk/pdbsum/1klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1klx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [https://pdbe.org/1klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [https://www.ebi.ac.uk/pdbsum/1klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1klx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HCPB_HELPY HCPB_HELPY]] Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.	+	[https://www.uniprot.org/uniprot/HCPB_HELPY HCPB_HELPY] Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1klx ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1klx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Colonization of the gastric mucosa with the spiral-shaped Gram-negative proteobacterium Helicobacter pylori is probably the most common chronic infection in humans. The genomes of H. pylori strains J99 and 26695 have been completely sequenced. Functional and three-dimensional structural information is available for less than one third of all open reading frames. We investigated the function and three-dimensional structure of a member from a family of cysteine-rich hypothetical proteins that are unique to H. pylori and Campylobacter jejuni. The structure of H. pylori cysteine-rich protein (Hcp) B possesses a modular architecture consisting of four alpha/alpha-motifs that are cross-linked by disulfide bridges. The Hcp repeat is similar to the tetratricopeptide repeat, which is frequently found in protein/protein interactions. In contrast to the tetratricopeptide repeat, the Hcp repeat is 36 amino acids long. HcpB is capable of binding and hydrolyzing 6-amino penicillinic acid and 7-amino cephalosporanic acid derivatives. The HcpB fold is distinct from the fold of any known penicillin-binding protein, indicating that the Hcp proteins comprise a new family of penicillin-binding proteins. The putative penicillin binding site is located in an amphipathic groove on the concave side of the molecule.
-
-	The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein.,Luthy L, Grutter MG, Mittl PR J Biol Chem. 2002 Mar 22;277(12):10187-93. Epub 2002 Jan 2. PMID:11777911<ref>PMID:11777911</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1klx" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 43504~~]]	+	[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gruetter~~, M G~~]]	+	[[Category: Gruetter MG]]
-	[[Category: Luethy, L]]	+	[[Category: Luethy L]]
-	[[Category: Mittl~~, P R.E]]~~	+	[[Category: Mittl PRE]]
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Modular structureses']]~~	+
-	~~[[Category: Right handed super helix]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 05:51, 28 April 2021

OCA — Wed, 28 Apr 2021 05:51:01 GMT

←Older revision		Revision as of 05:51, 28 April 2021
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	<StructureSection load='1klx' size='340' side='right'caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1klx' size='340' side='right'caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [~~http~~://pdbe.org/1klx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1klx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1klx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [https://pdbe.org/1klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [https://www.ebi.ac.uk/pdbsum/1klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1klx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HCPB_HELPY HCPB_HELPY]] Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.	+	[[https://www.uniprot.org/uniprot/HCPB_HELPY HCPB_HELPY]] Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:48, 24 July 2019

OCA — Wed, 24 Jul 2019 06:48:56 GMT

←Older revision		Revision as of 06:48, 24 July 2019
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	==Helicobacter pylori cysteine rich protein B (hcpB)==		==Helicobacter pylori cysteine rich protein B (hcpB)==
-	<StructureSection load='1klx' size='340' side='right' caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='1klx' size='340' side='right'caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1klx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1klx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43504]]		[[Category: Atcc 43504]]
		+	[[Category: Large Structures]]
	[[Category: Gruetter, M G]]		[[Category: Gruetter, M G]]
	[[Category: Luethy, L]]		[[Category: Luethy, L]]
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	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Modular ~~structures~~']]	+	[[Category: Modular structureses']]
	[[Category: Right handed super helix]]		[[Category: Right handed super helix]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 07:14, 11 October 2017

OCA — Wed, 11 Oct 2017 07:14:19 GMT

←Older revision		Revision as of 07:14, 11 October 2017
Line 1:		Line 1:
		+
	==Helicobacter pylori cysteine rich protein B (hcpB)==		==Helicobacter pylori cysteine rich protein B (hcpB)==
	<StructureSection load='1klx' size='340' side='right' caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1klx' size='340' side='right' caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [http://pdbe.org/1klx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [http://www.ebi.ac.uk/pdbsum/1klx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [http://pdbe.org/1klx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [http://www.ebi.ac.uk/pdbsum/1klx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1klx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1klx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:40, 11 September 2015

OCA — Fri, 11 Sep 2015 12:40:59 GMT

←Older revision		Revision as of 12:40, 11 September 2015
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	<StructureSection load='1klx' size='340' side='right' caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1klx' size='340' side='right' caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter pylori~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ~~Helicobacter pylori~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [http://www.ebi.ac.uk/pdbsum/1klx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [http://pdbe.org/1klx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [http://www.ebi.ac.uk/pdbsum/1klx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1klx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Helicobacter pylori~~]]	+	[[Category: Atcc 43504]]
	[[Category: Gruetter, M G]]		[[Category: Gruetter, M G]]
	[[Category: Luethy, L]]		[[Category: Luethy, L]]

OCA at 16:34, 25 December 2014

OCA — Thu, 25 Dec 2014 16:34:48 GMT

←Older revision		Revision as of 16:34, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [http://www.ebi.ac.uk/pdbsum/1klx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [http://www.ebi.ac.uk/pdbsum/1klx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HCPB_HELPY HCPB_HELPY]] Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Gruetter, M G.]]	+	[[Category: Gruetter, M G]]
-	[[Category: Luethy, L.]]	+	[[Category: Luethy, L]]
-	[[Category: Mittl, P R.E.]]	+	[[Category: Mittl, P R.E]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 10:49, 28 September 2014

OCA — Sun, 28 Sep 2014 10:49:02 GMT

←Older revision		Revision as of 10:49, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1klx.~~png\|left~~\|200px]]	+	==Helicobacter pylori cysteine rich protein B (hcpB)==
		+	<StructureSection load='1klx' size='340' side='right' caption='[[1klx]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP0336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1klx RCSB], [http://www.ebi.ac.uk/pdbsum/1klx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1klx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Colonization of the gastric mucosa with the spiral-shaped Gram-negative proteobacterium Helicobacter pylori is probably the most common chronic infection in humans. The genomes of H. pylori strains J99 and 26695 have been completely sequenced. Functional and three-dimensional structural information is available for less than one third of all open reading frames. We investigated the function and three-dimensional structure of a member from a family of cysteine-rich hypothetical proteins that are unique to H. pylori and Campylobacter jejuni. The structure of H. pylori cysteine-rich protein (Hcp) B possesses a modular architecture consisting of four alpha/alpha-motifs that are cross-linked by disulfide bridges. The Hcp repeat is similar to the tetratricopeptide repeat, which is frequently found in protein/protein interactions. In contrast to the tetratricopeptide repeat, the Hcp repeat is 36 amino acids long. HcpB is capable of binding and hydrolyzing 6-amino penicillinic acid and 7-amino cephalosporanic acid derivatives. The HcpB fold is distinct from the fold of any known penicillin-binding protein, indicating that the Hcp proteins comprise a new family of penicillin-binding proteins. The putative penicillin binding site is located in an amphipathic groove on the concave side of the molecule.

-	~~{{STRUCTURE_1klx\| PDB=1klx \| SCENE= }}~~	+	The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein.,Luthy L, Grutter MG, Mittl PR J Biol Chem. 2002 Mar 22;277(12):10187-93. Epub 2002 Jan 2. PMID:11777911<ref>PMID:11777911</ref>

-	~~===Helicobacter pylori cysteine rich protein B (hcpB)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11777911}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1klx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Helicobacter_pylori Helicobacter pylori]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011777911<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Gruetter, M G.]]		[[Category: Gruetter, M G.]]

OCA: Protected "1klx" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:33:55 GMT

Protected "1klx" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:33, 5 December 2012

OCA at 20:33, 5 December 2012

OCA — Wed, 05 Dec 2012 20:33:50 GMT

←Older revision		Revision as of 20:33, 5 December 2012
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-	{{Seed}}
	[[Image:1klx.png\|left\|200px]]		[[Image:1klx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1klx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1klx\| PDB=1klx \| SCENE= }}		{{STRUCTURE_1klx\| PDB=1klx \| SCENE= }}

	===Helicobacter pylori cysteine rich protein B (hcpB)===		===Helicobacter pylori cysteine rich protein B (hcpB)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11777911}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11777911 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11777911}}		{{ABSTRACT_PUBMED_11777911}}

	==About this Structure==		==About this Structure==
-	~~1KLX~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA].	+	[[1klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11777911~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011777911</ref><references group="xtra"/>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Gruetter, M G.]]		[[Category: Gruetter, M G.]]
Line 29:		Line 17:
	[[Category: Mittl, P R.E.]]		[[Category: Mittl, P R.E.]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
		+	[[Category: Hydrolase]]
	[[Category: Modular structures']]		[[Category: Modular structures']]
	[[Category: Right handed super helix]]		[[Category: Right handed super helix]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:54:20 2009''

OCA at 19:54, 17 February 2009

OCA — Tue, 17 Feb 2009 19:54:21 GMT

←Older revision		Revision as of 19:54, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1KLX is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA].	+	1KLX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLX OCA].

	==Reference==		==Reference==
-	The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein., Luthy L, Grutter MG, Mittl PR, J Biol Chem. 2002 Mar 22;277(12):10187-93. Epub 2002 Jan 2. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11777911 11777911]~~	+	<ref group="xtra">PMID:11777911</ref><references group="xtra"/>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Single protein]]
	[[Category: Gruetter, M G.]]		[[Category: Gruetter, M G.]]
	[[Category: Luethy, L.]]		[[Category: Luethy, L.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 10~~:32:~~00 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:54:20 2009''