1kpe - Revision history

OCA at 07:26, 14 February 2024

OCA — Wed, 14 Feb 2024 07:26:37 GMT

←Older revision		Revision as of 07:26, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1kpe' size='340' side='right'caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1kpe' size='340' side='right'caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1KPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KPE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADW:ADENOSINE~~-~~5-DITUNGSTATE'>ADW</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [https://pdbe.org/1kpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [https://www.ebi.ac.uk/pdbsum/1kpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kpe ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [~~http~~://pdbe.org/1kpe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kpe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kpe ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).	+	[https://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kpe ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kpe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.
-
-	Structure-based analysis of catalysis and substrate definition in the HIT protein family.,Lima CD, Klein MG, Hendrickson WA Science. 1997 Oct 10;278(5336):286-90. PMID:9323207<ref>PMID:9323207</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1kpe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Histidine triad nucleotide-binding protein 3D structures\|Histidine triad nucleotide-binding protein 3D structures]]		*[[Histidine triad nucleotide-binding protein 3D structures\|Histidine triad nucleotide-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hendrickson~~, W A~~]]	+	[[Category: Hendrickson WA]]
-	[[Category: Klein~~, M G~~]]	+	[[Category: Klein MG]]
-	[[Category: Lima~~, C D]]~~	+	[[Category: Lima CD]]
-	~~[[Category: Histidine triad protein family]]~~	+
-	~~[[Category: Hit protein family]]~~	+
-	~~[[Category: Nucleotidyl hydrolase]]~~	+
-	~~[[Category: Nucleotidyl transferase]]~~	+
-	~~[[Category: Pentacovalent nucleotidyl histidyl-tungstate complex]]~~	+
-	~~[[Category: Pkci-1]]~~	+
-	~~[[Category: Protein kinase inhibitor~~]]	+

OCA at 07:48, 25 November 2020

OCA — Wed, 25 Nov 2020 07:48:15 GMT

←Older revision		Revision as of 07:48, 25 November 2020
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	==PKCI-TRANSITION STATE ANALOG==		==PKCI-TRANSITION STATE ANALOG==
-	<StructureSection load='1kpe' size='340' side='right' caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1kpe' size='340' side='right'caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KPE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://pdbe.org/1kpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kpe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://pdbe.org/1kpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kpe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1kpe" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kpe" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histidine triad nucleotide-binding protein 3D structures\|Histidine triad nucleotide-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hendrickson, W A]]		[[Category: Hendrickson, W A]]
	[[Category: Klein, M G]]		[[Category: Klein, M G]]

OCA at 21:40, 24 January 2018

OCA — Wed, 24 Jan 2018 21:40:49 GMT

←Older revision		Revision as of 21:40, 24 January 2018
Line 1:		Line 1:
		+
	==PKCI-TRANSITION STATE ANALOG==		==PKCI-TRANSITION STATE ANALOG==
	<StructureSection load='1kpe' size='340' side='right' caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1kpe' size='340' side='right' caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://pdbe.org/1kpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://pdbe.org/1kpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kpe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/1kpe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/1kpe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1kpe" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kpe" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Histidine triad nucleotide-binding protein\|Histidine triad nucleotide-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:24, 7 February 2016

OCA — Sun, 07 Feb 2016 05:24:28 GMT

←Older revision		Revision as of 05:24, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kpe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:16, 9 September 2015

OCA — Wed, 09 Sep 2015 22:16:17 GMT

←Older revision		Revision as of 22:16, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1kpe' size='340' side='right' caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1kpe' size='340' side='right' caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KPE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://pdbe.org/1kpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kpe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hendrickson, W A]]		[[Category: Hendrickson, W A]]
	[[Category: Klein, M G]]		[[Category: Klein, M G]]

OCA at 08:10, 24 December 2014

OCA — Wed, 24 Dec 2014 08:10:57 GMT

←Older revision		Revision as of 08:10, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KPE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KPE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hendrickson, W A.]]	+	[[Category: Hendrickson, W A]]
-	[[Category: Klein, M G.]]	+	[[Category: Klein, M G]]
-	[[Category: Lima, C D.]]	+	[[Category: Lima, C D]]
	[[Category: Histidine triad protein family]]		[[Category: Histidine triad protein family]]
	[[Category: Hit protein family]]		[[Category: Hit protein family]]

OCA at 09:04, 3 October 2014

OCA — Fri, 03 Oct 2014 09:04:05 GMT

←Older revision		Revision as of 09:04, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1kpe~~\| ~~PDB~~=1kpe \| ~~SCENE~~= }}	+	==PKCI-TRANSITION STATE ANALOG==
-	===~~PKCI~~-~~TRANSITION STATE ANALOG~~===	+	<StructureSection load='1kpe' size='340' side='right' caption='[[1kpe]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_9323207}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KPE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADW:ADENOSINE-5-DITUNGSTATE'>ADW</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPKCI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kpe RCSB], [http://www.ebi.ac.uk/pdbsum/1kpe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/1kpe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.

-	~~==Function==~~	+	Structure-based analysis of catalysis and substrate definition in the HIT protein family.,Lima CD, Klein MG, Hendrickson WA Science. 1997 Oct 10;278(5336):286-90. PMID:9323207<ref>PMID:9323207</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate~~, ~~AMP-N-alanine methyl ester~~, ~~AMP-alpha-acetyl lysine methyl ester and AMP-NH2~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1kpe]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:009323207</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Histidine triad nucleotide-binding protein\|Histidine triad nucleotide-binding protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hendrickson, W A.]]		[[Category: Hendrickson, W A.]]

OCA at 10:46, 16 April 2014

OCA — Wed, 16 Apr 2014 10:46:46 GMT

←Older revision		Revision as of 10:46, 16 April 2014
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-	[[Image:1kpe.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1kpe", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1kpe\| PDB=1kpe \| SCENE= }}		{{STRUCTURE_1kpe\| PDB=1kpe \| SCENE= }}
-
	===PKCI-TRANSITION STATE ANALOG===		===PKCI-TRANSITION STATE ANALOG===
		+	{{ABSTRACT_PUBMED_9323207}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_9323207}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 9323207 is the PubMed ID number.~~	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_9323207}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:009323207</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009323207</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hendrickson, W A.]]		[[Category: Hendrickson, W A.]]

OCA: Protected "1kpe" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2011 08:05:41 GMT

Protected "1kpe" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:05, 3 August 2011

OCA at 08:05, 3 August 2011

OCA — Wed, 03 Aug 2011 08:05:39 GMT

←Older revision		Revision as of 08:05, 3 August 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1kpe.png\|left\|200px]]		[[Image:1kpe.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~1KPE~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA].	+	[[1kpe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9323207~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009323207</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hendrickson, W A.]]		[[Category: Hendrickson, W A.]]
Line 35:		Line 34:
	[[Category: Pkci-1]]		[[Category: Pkci-1]]
	[[Category: Protein kinase inhibitor]]		[[Category: Protein kinase inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:36:59 2009''