1kso - Revision history

OCA at 07:27, 14 February 2024

OCA — Wed, 14 Feb 2024 07:27:25 GMT

←Older revision		Revision as of 07:27, 14 February 2024
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	<StructureSection load='1kso' size='340' side='right'caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1kso' size='340' side='right'caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [https://pdbe.org/1kso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [https://www.ebi.ac.uk/pdbsum/1kso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kso ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [https://pdbe.org/1kso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [https://www.ebi.ac.uk/pdbsum/1kso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kso ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/S10A3_HUMAN S10A3_HUMAN]] Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.<ref>PMID:18083705</ref>	+	[https://www.uniprot.org/uniprot/S10A3_HUMAN S10A3_HUMAN] Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.<ref>PMID:18083705</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kso ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kso ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	S100 proteins are involved in metal-dependent intracellular signalling. Metal-free S100A3, a cysteine-rich Ca(2+)- and Zn(2+)-binding protein, has been crystallized by vapour diffusion under the strict exclusion of oxygen and in the absence of divalent metal ions. Metal binding induces large conformational changes, rendering the apo-S100A3 crystals very sensitive to various metal compounds. Therefore, the structure was solved by MIRAS phasing using potassium iodide and xenon derivatives. Iodide replaces a water molecule at the surface of the S100A3 protein, whereas xenon binds in a hydrophobic cavity at the dimer interface. Despite significant non-isomorphism, the combination of both derivatives was sufficient for structure determination. The overall apo-S100A3 structure resembles the structures of metal-free S100B and S100A6 solution structures. In contrast to the NMR structures, the EF-hand loops are well ordered in the apo-S100A3 crystal structure. In the N-terminal pseudo-EF-hand loop a water molecule occupies the position of the Ca(2+) ion. The C-terminal canonical EF-hand loop shows an extended conformation and a different helix arrangement to other S100/metal complex crystal structures.
-
-	Metal-free MIRAS phasing: structure of apo-S100A3.,Mittl PR, Fritz G, Sargent DF, Richmond TJ, Heizmann CW, Grutter MG Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1255-61. Epub 2002, Jul 20. PMID:12136135<ref>PMID:12136135</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fritz, G]]	+	[[Category: Fritz G]]
-	[[Category: Grutter~~, M G~~]]	+	[[Category: Grutter MG]]
-	[[Category: Heizmann~~, C W~~]]	+	[[Category: Heizmann CW]]
-	[[Category: Mittl~~, P R~~]]	+	[[Category: Mittl PR]]
-	[[Category: Richmond~~, T J~~]]	+	[[Category: Richmond TJ]]
-	[[Category: Sargent~~, D F]]~~	+	[[Category: Sargent DF]]
-	~~[[Category: Ca2+ binding protein]]~~	+
-	~~[[Category: Ef-hand]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: S100]]~~	+
-	~~[[Category: Zn2+ binding protein~~]]	+

OCA at 06:35, 18 August 2021

OCA — Wed, 18 Aug 2021 06:35:13 GMT

←Older revision		Revision as of 06:35, 18 August 2021
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	<StructureSection load='1kso' size='340' side='right'caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1kso' size='340' side='right'caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [~~http~~://pdbe.org/1kso PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kso PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kso ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [https://pdbe.org/1kso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [https://www.ebi.ac.uk/pdbsum/1kso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kso ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/S10A3_HUMAN S10A3_HUMAN]] Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.<ref>PMID:18083705</ref>	+	[[https://www.uniprot.org/uniprot/S10A3_HUMAN S10A3_HUMAN]] Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.<ref>PMID:18083705</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[S100 ~~protein~~\|S100 ~~protein~~]]	+	*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:10, 13 November 2019

OCA — Wed, 13 Nov 2019 12:10:23 GMT

←Older revision		Revision as of 12:10, 13 November 2019
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	==CRYSTAL STRUCTURE OF APO S100A3==		==CRYSTAL STRUCTURE OF APO S100A3==
-	<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1kso' size='340' side='right'caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fritz, G]]		[[Category: Fritz, G]]
	[[Category: Grutter, M G]]		[[Category: Grutter, M G]]

OCA at 06:23, 31 January 2018

OCA — Wed, 31 Jan 2018 06:23:15 GMT

←Older revision		Revision as of 06:23, 31 January 2018
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	<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://pdbe.org/1kso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kso ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://pdbe.org/1kso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kso ProSAT]</span></td></tr>
	</table>		</table>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/1kso_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/1kso_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Fritz, G]]		[[Category: Fritz, G]]
	[[Category: Grutter, M G]]		[[Category: Grutter, M G]]

OCA at 01:23, 10 March 2017

OCA — Fri, 10 Mar 2017 01:23:21 GMT

←Older revision		Revision as of 01:23, 10 March 2017
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:02, 1 February 2017

OCA — Wed, 01 Feb 2017 11:02:43 GMT

←Older revision		Revision as of 11:02, 1 February 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF APO S100A3==		==CRYSTAL STRUCTURE OF APO S100A3==
	<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://pdbe.org/1kso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://pdbe.org/1kso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kso ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Fritz, G]]		[[Category: Fritz, G]]
	[[Category: Grutter, M G]]		[[Category: Grutter, M G]]
	[[Category: Heizmann, C W]]		[[Category: Heizmann, C W]]
-	[[Category: Mittl, P R.E]]	+	[[Category: Mittl, P R]]
	[[Category: Richmond, T J]]		[[Category: Richmond, T J]]
	[[Category: Sargent, D F]]		[[Category: Sargent, D F]]

OCA at 07:40, 10 February 2016

OCA — Wed, 10 Feb 2016 07:40:52 GMT

←Older revision		Revision as of 07:40, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kso ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:47, 11 September 2015

OCA — Fri, 11 Sep 2015 06:47:16 GMT

←Older revision		Revision as of 06:47, 11 September 2015
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	<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://pdbe.org/1kso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kso" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fritz, G]]		[[Category: Fritz, G]]
	[[Category: Grutter, M G]]		[[Category: Grutter, M G]]

OCA at 12:47, 25 December 2014

OCA — Thu, 25 Dec 2014 12:47:09 GMT

←Older revision		Revision as of 12:47, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/S10A3_HUMAN S10A3_HUMAN]] Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.<ref>PMID:18083705</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fritz, G.]]	+	[[Category: Fritz, G]]
-	[[Category: Grutter, M G.]]	+	[[Category: Grutter, M G]]
-	[[Category: Heizmann, C W.]]	+	[[Category: Heizmann, C W]]
	[[Category: Mittl, P R.E]]		[[Category: Mittl, P R.E]]
-	[[Category: Richmond, T J.]]	+	[[Category: Richmond, T J]]
-	[[Category: Sargent, D F.]]	+	[[Category: Sargent, D F]]
	[[Category: Ca2+ binding protein]]		[[Category: Ca2+ binding protein]]
	[[Category: Ef-hand]]		[[Category: Ef-hand]]

OCA at 14:55, 28 September 2014

OCA — Sun, 28 Sep 2014 14:55:50 GMT

←Older revision		Revision as of 14:55, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1kso.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF APO S100A3==
		+	<StructureSection load='1kso' size='340' side='right' caption='[[1kso]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KSO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kso RCSB], [http://www.ebi.ac.uk/pdbsum/1kso PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/1kso_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S100 proteins are involved in metal-dependent intracellular signalling. Metal-free S100A3, a cysteine-rich Ca(2+)- and Zn(2+)-binding protein, has been crystallized by vapour diffusion under the strict exclusion of oxygen and in the absence of divalent metal ions. Metal binding induces large conformational changes, rendering the apo-S100A3 crystals very sensitive to various metal compounds. Therefore, the structure was solved by MIRAS phasing using potassium iodide and xenon derivatives. Iodide replaces a water molecule at the surface of the S100A3 protein, whereas xenon binds in a hydrophobic cavity at the dimer interface. Despite significant non-isomorphism, the combination of both derivatives was sufficient for structure determination. The overall apo-S100A3 structure resembles the structures of metal-free S100B and S100A6 solution structures. In contrast to the NMR structures, the EF-hand loops are well ordered in the apo-S100A3 crystal structure. In the N-terminal pseudo-EF-hand loop a water molecule occupies the position of the Ca(2+) ion. The C-terminal canonical EF-hand loop shows an extended conformation and a different helix arrangement to other S100/metal complex crystal structures.

-	~~{{STRUCTURE_1kso\| PDB=1kso \| SCENE= }}~~	+	Metal-free MIRAS phasing: structure of apo-S100A3.,Mittl PR, Fritz G, Sargent DF, Richmond TJ, Heizmann CW, Grutter MG Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1255-61. Epub 2002, Jul 20. PMID:12136135<ref>PMID:12136135</ref>

-	~~===CRYSTAL STRUCTURE OF APO S100A3===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_12136135}}~~	+	==See Also==
-		+	*[[S100 protein\|S100 protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1kso~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSO OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:012136135<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fritz, G.]]		[[Category: Fritz, G.]]