1kw2 - Revision history

OCA at 09:05, 16 August 2023

OCA — Wed, 16 Aug 2023 09:05:21 GMT

←Older revision		Revision as of 09:05, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1j78\|1j78]]~~, [[~~1kxp~~\|~~1kxp~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [https://pdbe.org/1kw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [https://www.ebi.ac.uk/pdbsum/1kw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kw2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [https://pdbe.org/1kw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [https://www.ebi.ac.uk/pdbsum/1kw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kw2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VTDB_HUMAN VTDB_HUMAN]] Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.	+	[https://www.uniprot.org/uniprot/VTDB_HUMAN VTDB_HUMAN] Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dominguez, R]]	+	[[Category: Dominguez R]]
-	[[Category: Otterbein~~, L R]]~~	+	[[Category: Otterbein LR]]
-	~~[[Category: Actin scavenger system]]~~	+
-	~~[[Category: Actin-binding protein]]~~	+
-	~~[[Category: Dbp]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Vitamin d-binding protein~~]]	+

OCA at 06:36, 18 August 2021

OCA — Wed, 18 Aug 2021 06:36:19 GMT

←Older revision		Revision as of 06:36, 18 August 2021
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	<StructureSection load='1kw2' size='340' side='right'caption='[[1kw2]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1kw2' size='340' side='right'caption='[[1kw2]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j78\|1j78]], [[1kxp\|1kxp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [~~http~~://pdbe.org/1kw2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kw2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kw2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [https://pdbe.org/1kw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [https://www.ebi.ac.uk/pdbsum/1kw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kw2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VTDB_HUMAN VTDB_HUMAN]] Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.	+	[[https://www.uniprot.org/uniprot/VTDB_HUMAN VTDB_HUMAN]] Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:41, 13 November 2019

OCA — Wed, 13 Nov 2019 12:41:13 GMT

←Older revision		Revision as of 12:41, 13 November 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN==		==CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN==
-	<StructureSection load='1kw2' size='340' side='right' caption='[[1kw2]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='1kw2' size='340' side='right'caption='[[1kw2]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Dominguez, R]]		[[Category: Dominguez, R]]
	[[Category: Otterbein, L R]]		[[Category: Otterbein, L R]]

OCA at 21:51, 24 January 2018

OCA — Wed, 24 Jan 2018 21:51:11 GMT

←Older revision		Revision as of 21:51, 24 January 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN==		==CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN==
	<StructureSection load='1kw2' size='340' side='right' caption='[[1kw2]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1kw2' size='340' side='right' caption='[[1kw2]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [http://pdbe.org/1kw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kw2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [http://pdbe.org/1kw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kw2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/1kw2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/1kw2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:47, 8 February 2016

OCA — Mon, 08 Feb 2016 01:47:00 GMT

←Older revision		Revision as of 01:47, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kw2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:43, 10 September 2015

OCA — Thu, 10 Sep 2015 06:43:43 GMT

←Older revision		Revision as of 06:43, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kw2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [http://pdbe.org/1kw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kw2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kw2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:40, 24 December 2014

OCA — Wed, 24 Dec 2014 19:40:07 GMT

←Older revision		Revision as of 19:40, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kw2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kw2 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VTDB_HUMAN VTDB_HUMAN]] Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dominguez, R.]]	+	[[Category: Dominguez, R]]
-	[[Category: Otterbein, L R.]]	+	[[Category: Otterbein, L R]]
	[[Category: Actin scavenger system]]		[[Category: Actin scavenger system]]
	[[Category: Actin-binding protein]]		[[Category: Actin-binding protein]]

OCA at 15:19, 28 September 2014

OCA — Sun, 28 Sep 2014 15:19:06 GMT

←Older revision		Revision as of 15:19, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1kw2.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN==
		+	<StructureSection load='1kw2' size='340' side='right' caption='[[1kw2]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KW2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j78\|1j78]], [[1kxp\|1kxp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kw2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kw2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/1kw2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Actin is the most abundant protein in eukaryotic cells, but its release from cells into blood vessels can be lethal, being associated with clinical situations including hepatic necrosis and septic shock. A homeostatic mechanism, termed the actin-scavenger system, is responsible for the depolymerization and removal of actin from the circulation. During the first phase of this mechanism, gelsolin severs the actin filaments. In the second phase, the vitamin D-binding protein (DBP) traps the actin monomers, which accelerates their clearance. We have determined the crystal structures of DBP by itself and complexed with actin to 2.1 A resolution. Similar to its homologue serum albumin, DBP consists of three related domains. Yet, in DBP a strikingly different organization of the domains gives rise to a large actin-binding cavity. After complex formation the three domains of DBP move slightly to "clamp" onto actin subdomain 3 and to a lesser extent subdomain 1. Contacts between actin and DBP throughout their extensive 3,454-A(2) intermolecular interface involve a mixture of hydrophobic, electrostatic, and solvent-mediated interactions. The area of actin covered by DBP within the complex approximately equals the sum of those covered by gelsolin and profilin. Moreover, certain interactions of DBP with actin mirror those observed in the actin-gelsolin complex, which may explain how DBP can compete effectively with gelsolin for actin binding. Formation of the strong actin-DBP complex proceeds with limited conformational changes to both proteins, demonstrating how DBP has evolved to become an effective actin-scavenger protein.

-	~~{{STRUCTURE_1kw2\| PDB=1kw2 \| SCENE= }}~~	+	Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system.,Otterbein LR, Cosio C, Graceffa P, Dominguez R Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8003-8. Epub 2002 Jun 4. PMID:12048248<ref>PMID:12048248</ref>

-	~~===CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12048248}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1kw2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012048248<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dominguez, R.]]		[[Category: Dominguez, R.]]

OCA: Protected "1kw2" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 21:29:57 GMT

Protected "1kw2" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:29, 5 December 2012

OCA at 21:29, 5 December 2012

OCA — Wed, 05 Dec 2012 21:29:55 GMT

←Older revision		Revision as of 21:29, 5 December 2012
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-	{{Seed}}
	[[Image:1kw2.png\|left\|200px]]		[[Image:1kw2.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1kw2\| PDB=1kw2 \| SCENE= }}		{{STRUCTURE_1kw2\| PDB=1kw2 \| SCENE= }}

	===CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN===		===CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12048248}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12048248 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12048248}}		{{ABSTRACT_PUBMED_12048248}}

	==About this Structure==		==About this Structure==
-	~~1KW2~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA].	+	[[1kw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12048248~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012048248</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dominguez, R.]]		[[Category: Dominguez, R.]]
Line 30:		Line 18:
	[[Category: Actin-binding protein]]		[[Category: Actin-binding protein]]
	[[Category: Dbp]]		[[Category: Dbp]]
		+	[[Category: Transport protein]]
	[[Category: Vitamin d-binding protein]]		[[Category: Vitamin d-binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:55:17 2009''