1l0y - Revision history

OCA at 08:05, 3 April 2024

OCA — Wed, 03 Apr 2024 08:05:29 GMT

←Older revision		Revision as of 08:05, 3 April 2024
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	<StructureSection load='1l0y' size='340' side='right'caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l0y' size='340' side='right'caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow: auto; max-height~~: ~~3em;~~'>~~[[1l0x\|1l0x]]~~, ~~[[1sbb\|1sbb]], [[1jck\|1jck]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [https://pdbe.org/1l0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [https://www.ebi.ac.uk/pdbsum/1l0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l0y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [https://pdbe.org/1l0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [https://www.ebi.ac.uk/pdbsum/1l0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l0y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~SPEA_STRPY SPEA_STRPY~~]~~] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.~~	+	[https://www.uniprot.org/uniprot/TCB2_MOUSE TCB2_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l0y ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l0y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an overstimulation of T cells associated with human disease. SAGs interact with several different surfaces on MHC molecules, necessitating the formation of multiple distinct MHC-SAG-TCR ternary signaling complexes. Variability in SAG-TCR binding modes could also contribute to the structural heterogeneity of SAG-dependent signaling complexes. We report crystal structures of the streptococcal SAGs SpeA and SpeC in complex with their corresponding TCR beta chain ligands that reveal distinct TCR binding modes. The SpeC-TCR beta chain complex structure, coupled with the recently determined SpeC-HLA-DR2a complex structure, provides a model for a novel T cell signaling complex that precludes direct TCR-MHC interactions. Thus, highly efficient T cell activation may be achieved through structurally diverse strategies of TCR ligation.
-
-	Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.,Sundberg EJ, Li H, Llera AS, McCormick JK, Tormo J, Schlievert PM, Karjalainen K, Mariuzza RA Structure. 2002 May;10(5):687-99. PMID:12015151<ref>PMID:12015151</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1l0y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]		*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]		*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Micrococcus scarlatinae klein 1884]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Li, H~~]]	+	[[Category: Streptococcus pyogenes]]
-	[[Category: ~~Mariuzza, R A~~]]	+	[[Category: Li H]]
-	[[Category: ~~Sundberg, E J~~]]	+	[[Category: Mariuzza RA]]
-	[[Category: ~~Immune system]]~~	+	[[Category: Sundberg EJ]]
-	~~[[Category: Spea]]~~	+
-	~~[[Category: Superantigen]]~~	+
-	~~[[Category: Tcr~~]]	+

OCA at 06:38, 18 August 2021

OCA — Wed, 18 Aug 2021 06:38:06 GMT

←Older revision		Revision as of 06:38, 18 August 2021
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	<StructureSection load='1l0y' size='340' side='right'caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l0y' size='340' side='right'caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [~~http~~://pdbe.org/1l0y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l0y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l0y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [https://pdbe.org/1l0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [https://www.ebi.ac.uk/pdbsum/1l0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l0y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.	+	[[https://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]		*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
-	*[[T-cell receptor\|T-cell receptor]]	+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:10, 13 November 2019

OCA — Wed, 13 Nov 2019 12:10:55 GMT

←Older revision		Revision as of 12:10, 13 November 2019
Line 1:		Line 1:

	==T cell receptor beta chain complexed with superantigen SpeA soaked with zinc==		==T cell receptor beta chain complexed with superantigen SpeA soaked with zinc==
-	<StructureSection load='1l0y' size='340' side='right' caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1l0y' size='340' side='right'caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1l0y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1l0y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
		+	*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Micrococcus scarlatinae klein 1884]]		[[Category: Micrococcus scarlatinae klein 1884]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 21:20, 24 January 2018

OCA — Wed, 24 Jan 2018 21:20:30 GMT

←Older revision		Revision as of 21:20, 24 January 2018
Line 1:		Line 1:
		+
	==T cell receptor beta chain complexed with superantigen SpeA soaked with zinc==		==T cell receptor beta chain complexed with superantigen SpeA soaked with zinc==
	<StructureSection load='1l0y' size='340' side='right' caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l0y' size='340' side='right' caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [http://pdbe.org/1l0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [http://www.ebi.ac.uk/pdbsum/1l0y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [http://pdbe.org/1l0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [http://www.ebi.ac.uk/pdbsum/1l0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l0y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/1l0y_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/1l0y_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1l0y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1l0y" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Exotoxin\|Exotoxin]]
-	*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:20, 7 February 2016

OCA — Sun, 07 Feb 2016 18:20:03 GMT

←Older revision		Revision as of 18:20, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l0y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:59, 10 September 2015

OCA — Thu, 10 Sep 2015 03:59:23 GMT

←Older revision		Revision as of 03:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1l0y' size='340' side='right' caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l0y' size='340' side='right' caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~] and [http://en.wikipedia.org/wiki/~~Streptococcus_pyogenes Streptococcus pyogenes~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [http://www.ebi.ac.uk/pdbsum/1l0y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [http://pdbe.org/1l0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [http://www.ebi.ac.uk/pdbsum/1l0y PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l0y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Micrococcus scarlatinae klein 1884]]
-	[[Category: ~~Streptococcus pyogenes~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Mariuzza, R A]]		[[Category: Mariuzza, R A]]

OCA at 17:23, 24 December 2014

OCA — Wed, 24 Dec 2014 17:23:02 GMT

←Older revision		Revision as of 17:23, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [http://www.ebi.ac.uk/pdbsum/1l0y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [http://www.ebi.ac.uk/pdbsum/1l0y PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Streptococcus pyogenes]]		[[Category: Streptococcus pyogenes]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Mariuzza, R A.]]	+	[[Category: Mariuzza, R A]]
-	[[Category: Sundberg, E J.]]	+	[[Category: Sundberg, E J]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Spea]]		[[Category: Spea]]
	[[Category: Superantigen]]		[[Category: Superantigen]]
	[[Category: Tcr]]		[[Category: Tcr]]

OCA at 04:09, 3 October 2014

OCA — Fri, 03 Oct 2014 04:09:42 GMT

←Older revision		Revision as of 04:09, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1l0y\| PDB=1l0y \| SCENE= }}~~	+	==T cell receptor beta chain complexed with superantigen SpeA soaked with zinc==
-	===T cell receptor beta chain complexed with superantigen SpeA soaked with zinc===	+	<StructureSection load='1l0y' size='340' side='right' caption='[[1l0y]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12015151}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L0Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l0x\|1l0x]], [[1sbb\|1sbb]], [[1jck\|1jck]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l0y RCSB], [http://www.ebi.ac.uk/pdbsum/1l0y PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/1l0y_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an overstimulation of T cells associated with human disease. SAGs interact with several different surfaces on MHC molecules, necessitating the formation of multiple distinct MHC-SAG-TCR ternary signaling complexes. Variability in SAG-TCR binding modes could also contribute to the structural heterogeneity of SAG-dependent signaling complexes. We report crystal structures of the streptococcal SAGs SpeA and SpeC in complex with their corresponding TCR beta chain ligands that reveal distinct TCR binding modes. The SpeC-TCR beta chain complex structure, coupled with the recently determined SpeC-HLA-DR2a complex structure, provides a model for a novel T cell signaling complex that precludes direct TCR-MHC interactions. Thus, highly efficient T cell activation may be achieved through structurally diverse strategies of TCR ligation.

-	~~==Function==~~	+	Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.,Sundberg EJ, Li H, Llera AS, McCormick JK, Tormo J, Schlievert PM, Karjalainen K, Mariuzza RA Structure. 2002 May;10(5):687-99. PMID:12015151<ref>PMID:12015151</ref>
-	~~[[http://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent~~ of ~~the symptoms associated with scarlet fever, have been associated with~~ streptococcal ~~toxic shock-like disease and may play a role~~ in the ~~early events~~ of ~~rheumatic fever~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1l0y]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus] and [http://en~~.~~wikipedia.org~~/~~wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA].~~	+	</div>

	==See Also==		==See Also==
		+	*[[Exotoxin\|Exotoxin]]
	*[[T-cell receptor\|T-cell receptor]]		*[[T-cell receptor\|T-cell receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012015151</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Streptococcus pyogenes]]		[[Category: Streptococcus pyogenes]]

OCA at 07:02, 29 September 2013

OCA — Sun, 29 Sep 2013 07:02:01 GMT

←Older revision		Revision as of 07:02, 29 September 2013
Line 1:		Line 1:
-	[[Image:1l0y.png\|left\|200px]]
-
	{{STRUCTURE_1l0y\| PDB=1l0y \| SCENE= }}		{{STRUCTURE_1l0y\| PDB=1l0y \| SCENE= }}
-
	===T cell receptor beta chain complexed with superantigen SpeA soaked with zinc===		===T cell receptor beta chain complexed with superantigen SpeA soaked with zinc===
-
	{{ABSTRACT_PUBMED_12015151}}		{{ABSTRACT_PUBMED_12015151}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.

	==About this Structure==		==About this Structure==
	[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA].		[[1l0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Y OCA].
		+
		+	==See Also==
		+	*[[T-cell receptor\|T-cell receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012015151</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012015151</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Streptococcus pyogenes]]		[[Category: Streptococcus pyogenes]]

OCA: Protected "1l0y" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 19:46:24 GMT

Protected "1l0y" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:46, 5 December 2012