1l1j - Revision history

OCA at 13:26, 13 March 2024

OCA — Wed, 13 Mar 2024 13:26:23 GMT

←Older revision		Revision as of 13:26, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='1l1j' size='340' side='right'caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1l1j' size='340' side='right'caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [https://pdbe.org/1l1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [https://www.ebi.ac.uk/pdbsum/1l1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1j ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [https://pdbe.org/1l1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [https://www.ebi.ac.uk/pdbsum/1l1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9WZ41_THEMA Q9WZ41_THEMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1j ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	HtrA (high temperature requirement A), a periplasmic heat-shock protein, functions as a molecular chaperone at low temperatures, and its proteolytic activity is turned on at elevated temperatures. To investigate the mechanism of functional switch to protease, we determined the crystal structure of the NH(2)-terminal protease domain (PD) of HtrA from Thermotoga maritima, which was shown to retain both proteolytic and chaperone-like activities. Three subunits of HtrA PD compose a trimer, and multimerization architecture is similar to that found in the crystal structures of intact HtrA hexamer from Escherichia coli and human HtrA2 trimer. HtrA PD shares the same fold with chymotrypsin-like serine proteases, but it contains an additional lid that blocks access the of substrates to the active site. A corresponding lid found in E. coli HtrA is a long loop that also blocks the active site of another subunit. These results suggest that the activation of the proteolytic function of HtrA at elevated temperatures might occur by a conformational change, which includes the opening of the helical lid to expose the active site and subsequent rearrangement of a catalytic triad and an oxyanion hole.
-
-	Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima.,Kim DY, Kim DR, Ha SC, Lokanath NK, Lee CJ, Hwang HY, Kim KK J Biol Chem. 2003 Feb 21;278(8):6543-51. Epub 2002 Nov 27. PMID:12458220<ref>PMID:12458220</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1l1j" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43589]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ha, S C~~]]	+	[[Category: Thermotoga maritima]]
-	[[Category: ~~Hwang, H Y~~]]	+	[[Category: Ha SC]]
-	[[Category: ~~Kim, D R~~]]	+	[[Category: Hwang HY]]
-	[[Category: Kim~~, D Y~~]]	+	[[Category: Kim DR]]
-	[[Category: Kim~~, K K~~]]	+	[[Category: Kim DY]]
-	[[Category: ~~Lokanath, N K~~]]	+	[[Category: Kim KK]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Lokanath NK]]
-	~~[[Category: Serine proteinase~~]]	+

OCA at 06:38, 18 August 2021

OCA — Wed, 18 Aug 2021 06:38:20 GMT

←Older revision		Revision as of 06:38, 18 August 2021
Line 3:		Line 3:
	<StructureSection load='1l1j' size='340' side='right'caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1l1j' size='340' side='right'caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L1J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [~~http~~://pdbe.org/1l1j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l1j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1j ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [https://pdbe.org/1l1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [https://www.ebi.ac.uk/pdbsum/1l1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1j ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 12:28, 13 November 2019

OCA — Wed, 13 Nov 2019 12:28:37 GMT

←Older revision		Revision as of 12:28, 13 November 2019
Line 1:		Line 1:

	==Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA==		==Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA==
-	<StructureSection load='1l1j' size='340' side='right' caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1l1j' size='340' side='right'caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43589]]		[[Category: Atcc 43589]]
		+	[[Category: Large Structures]]
	[[Category: Ha, S C]]		[[Category: Ha, S C]]
	[[Category: Hwang, H Y]]		[[Category: Hwang, H Y]]

OCA at 21:38, 24 January 2018

OCA — Wed, 24 Jan 2018 21:38:49 GMT

←Older revision		Revision as of 21:38, 24 January 2018
Line 1:		Line 1:
		+
	==Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA==		==Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA==
	<StructureSection load='1l1j' size='340' side='right' caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1l1j' size='340' side='right' caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [http://pdbe.org/1l1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [http://www.ebi.ac.uk/pdbsum/1l1j PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [http://pdbe.org/1l1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [http://www.ebi.ac.uk/pdbsum/1l1j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1j ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:57, 9 February 2016

OCA — Tue, 09 Feb 2016 11:57:06 GMT

←Older revision		Revision as of 11:57, 9 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:00, 10 September 2015

OCA — Thu, 10 Sep 2015 22:00:24 GMT

←Older revision		Revision as of 22:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1l1j' size='340' side='right' caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1l1j' size='340' side='right' caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermotoga_maritima Thermotoga maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [http://www.ebi.ac.uk/pdbsum/1l1j PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [http://pdbe.org/1l1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [http://www.ebi.ac.uk/pdbsum/1l1j PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l1j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermotoga maritima~~]]	+	[[Category: Atcc 43589]]
	[[Category: Ha, S C]]		[[Category: Ha, S C]]
	[[Category: Hwang, H Y]]		[[Category: Hwang, H Y]]

OCA at 16:54, 5 January 2015

OCA — Mon, 05 Jan 2015 16:54:51 GMT

←Older revision		Revision as of 16:54, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [http://www.ebi.ac.uk/pdbsum/1l1j PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [http://www.ebi.ac.uk/pdbsum/1l1j PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Ha, S C.]]	+	[[Category: Ha, S C]]
-	[[Category: Hwang, H Y.]]	+	[[Category: Hwang, H Y]]
-	[[Category: Kim, D R.]]	+	[[Category: Kim, D R]]
-	[[Category: Kim, D Y.]]	+	[[Category: Kim, D Y]]
-	[[Category: Kim, K K.]]	+	[[Category: Kim, K K]]
-	[[Category: Lokanath, N K.]]	+	[[Category: Lokanath, N K]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine proteinase]]		[[Category: Serine proteinase]]

OCA at 18:22, 28 September 2014

OCA — Sun, 28 Sep 2014 18:22:42 GMT

←Older revision		Revision as of 18:22, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1l1j.~~png\|left~~\|200px]]	+	==Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA==
		+	<StructureSection load='1l1j' size='340' side='right' caption='[[1l1j]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l1j RCSB], [http://www.ebi.ac.uk/pdbsum/1l1j PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HtrA (high temperature requirement A), a periplasmic heat-shock protein, functions as a molecular chaperone at low temperatures, and its proteolytic activity is turned on at elevated temperatures. To investigate the mechanism of functional switch to protease, we determined the crystal structure of the NH(2)-terminal protease domain (PD) of HtrA from Thermotoga maritima, which was shown to retain both proteolytic and chaperone-like activities. Three subunits of HtrA PD compose a trimer, and multimerization architecture is similar to that found in the crystal structures of intact HtrA hexamer from Escherichia coli and human HtrA2 trimer. HtrA PD shares the same fold with chymotrypsin-like serine proteases, but it contains an additional lid that blocks access the of substrates to the active site. A corresponding lid found in E. coli HtrA is a long loop that also blocks the active site of another subunit. These results suggest that the activation of the proteolytic function of HtrA at elevated temperatures might occur by a conformational change, which includes the opening of the helical lid to expose the active site and subsequent rearrangement of a catalytic triad and an oxyanion hole.

-	~~{{STRUCTURE_1l1j\| PDB=1l1j \| SCENE= }}~~	+	Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima.,Kim DY, Kim DR, Ha SC, Lokanath NK, Lee CJ, Hwang HY, Kim KK J Biol Chem. 2003 Feb 21;278(8):6543-51. Epub 2002 Nov 27. PMID:12458220<ref>PMID:12458220</ref>

-	~~===Crystal structure~~ of the ~~protease domain of an ATP-independent heat shock protease HtrA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12458220}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1l1j]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermotoga_maritima Thermotoga maritima]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012458220<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Ha, S C.]]		[[Category: Ha, S C.]]

OCA: Protected "1l1j" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 21:12:33 GMT

Protected "1l1j" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:12, 5 December 2012

OCA at 21:12, 5 December 2012

OCA — Wed, 05 Dec 2012 21:12:31 GMT

←Older revision		Revision as of 21:12, 5 December 2012
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-	{{Seed}}
	[[Image:1l1j.png\|left\|200px]]		[[Image:1l1j.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1l1j\| PDB=1l1j \| SCENE= }}		{{STRUCTURE_1l1j\| PDB=1l1j \| SCENE= }}

	===Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA===		===Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA===

-
-	<!--
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	{{ABSTRACT_PUBMED_12458220}}		{{ABSTRACT_PUBMED_12458220}}

	==About this Structure==		==About this Structure==
-	~~1L1J~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA].	+	[[1l1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1J OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12458220~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012458220</ref><references group="xtra"/>
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Ha, S C.]]		[[Category: Ha, S C.]]
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine proteinase]]		[[Category: Serine proteinase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:35:37 2009''