1l2u - Revision history

OCA at 09:08, 16 August 2023

OCA — Wed, 16 Aug 2023 09:08:51 GMT

←Older revision		Revision as of 09:08, 16 August 2023
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	<StructureSection load='1l2u' size='340' side='right'caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l2u' size='340' side='right'caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2U FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1eix\|1eix]]~~, [[~~1jjk~~\|~~1jjk~~]]~~</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en~~.~~wikipedia.org/wiki/Orotidine-~~5~~'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [https://pdbe.org/1l2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [https://www.ebi.ac.uk/pdbsum/1l2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [https://pdbe.org/1l2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [https://www.ebi.ac.uk/pdbsum/1l2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PYRF_ECOLI PYRF_ECOLI]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_B]	+	[https://www.uniprot.org/uniprot/PYRF_ECOLI PYRF_ECOLI] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_B]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Orotidine-5'-phosphate decarboxylase]]~~	+	[[Category: Harris P]]
-	[[Category: Harris, P]]	+	[[Category: Jensen KF]]
-	[[Category: Jensen~~, K F~~]]	+	[[Category: Larsen S]]
-	[[Category: Larsen, S]]	+	[[Category: Poulsen JC]]
-	[[Category: Poulsen~~, J C]]~~	+
-	~~[[Category: Beta-alpha-barrel]]~~	+
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Twinned crystal~~]]	+

OCA at 09:51, 15 September 2021

OCA — Wed, 15 Sep 2021 09:51:56 GMT

←Older revision		Revision as of 09:51, 15 September 2021
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	<StructureSection load='1l2u' size='340' side='right'caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l2u' size='340' side='right'caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L2U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2U FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1eix\|1eix]], [[1jjk\|1jjk]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [~~http~~://pdbe.org/1l2u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l2u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [https://pdbe.org/1l2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [https://www.ebi.ac.uk/pdbsum/1l2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PYRF_ECOLI PYRF_ECOLI]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_B]	+	[[https://www.uniprot.org/uniprot/PYRF_ECOLI PYRF_ECOLI]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_B]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]	+	*[[Uridine 5'-monophosphate synthase 3D structures\|Uridine 5'-monophosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:39, 11 December 2019

OCA — Wed, 11 Dec 2019 19:39:49 GMT

←Older revision		Revision as of 19:39, 11 December 2019
Line 1:		Line 1:

	==Orotidine 5'-monophosphate decarboxylase from E. coli==		==Orotidine 5'-monophosphate decarboxylase from E. coli==
-	<StructureSection load='1l2u' size='340' side='right' caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1l2u' size='340' side='right'caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2U FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1l2u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1l2u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Harris, P]]		[[Category: Harris, P]]

OCA at 05:27, 8 March 2018

OCA — Thu, 08 Mar 2018 05:27:19 GMT

←Older revision		Revision as of 05:27, 8 March 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:45, 18 October 2017

OCA — Wed, 18 Oct 2017 10:45:04 GMT

←Older revision		Revision as of 10:45, 18 October 2017
Line 1:		Line 1:
		+
	==Orotidine 5'-monophosphate decarboxylase from E. coli==		==Orotidine 5'-monophosphate decarboxylase from E. coli==
	<StructureSection load='1l2u' size='340' side='right' caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l2u' size='340' side='right' caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [http://pdbe.org/1l2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [http://www.ebi.ac.uk/pdbsum/1l2u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [http://pdbe.org/1l2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [http://www.ebi.ac.uk/pdbsum/1l2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:28, 11 September 2015

OCA — Fri, 11 Sep 2015 12:28:20 GMT

←Older revision		Revision as of 12:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1l2u' size='340' side='right' caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1l2u' size='340' side='right' caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2U FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [http://www.ebi.ac.uk/pdbsum/1l2u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [http://pdbe.org/1l2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [http://www.ebi.ac.uk/pdbsum/1l2u PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l2u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Harris, P]]		[[Category: Harris, P]]

OCA at 16:27, 25 December 2014

OCA — Thu, 25 Dec 2014 16:27:05 GMT

←Older revision		Revision as of 16:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [http://www.ebi.ac.uk/pdbsum/1l2u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [http://www.ebi.ac.uk/pdbsum/1l2u PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYRF_ECOLI PYRF_ECOLI]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_B]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
-	[[Category: Harris, P.]]	+	[[Category: Harris, P]]
-	[[Category: Jensen, K F.]]	+	[[Category: Jensen, K F]]
-	[[Category: Larsen, S.]]	+	[[Category: Larsen, S]]
-	[[Category: Poulsen, J C.]]	+	[[Category: Poulsen, J C]]
	[[Category: Beta-alpha-barrel]]		[[Category: Beta-alpha-barrel]]
	[[Category: Homodimer]]		[[Category: Homodimer]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Twinned crystal]]		[[Category: Twinned crystal]]

OCA at 14:39, 28 September 2014

OCA — Sun, 28 Sep 2014 14:39:27 GMT

←Older revision		Revision as of 14:39, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1l2u.~~png~~\|~~left~~\|200px]]	+	==Orotidine 5'-monophosphate decarboxylase from E. coli==
		+	<StructureSection load='1l2u' size='340' side='right' caption='[[1l2u]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eix\|1eix]], [[1jjk\|1jjk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2u RCSB], [http://www.ebi.ac.uk/pdbsum/1l2u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Orotidine 5'-monophosphate decarboxylase (ODCase) catalyses the decarboxylation of orotidine 5'-monophosphate to uridine 5'-monophosphate (UMP). We have earlier determined the structure of ODCase from Escherichia coli complexed with the inhibitor 1-(5'-phospho-beta-d-ribofuranosyl)barbituric acid (BMP); here we present the 2.5 A structure of the uncomplexed apo enzyme, determined from twinned crystals. A structural analysis and comparison of the two structures of the E. coli enzyme show that binding of the inhibitor is accompanied by significant domain movements of approximately 12 degrees around a hinge that crosses the active site. Hence, the ODCase dimer, which contains two active sites, may be divided in three domains: a central domain that is fixed, and two lids which independently move 12 degrees upon binding. Corresponding analyses, presented herein, of the two Saccharomyces cerevisiae ODCase structures (with and without BMP) and the Methanobacterium thermoautotrophicum ODCase structures (with and without 6-aza UMP) show very similar, but somewhat smaller domain movements. The domain movements seem to be initiated by the phosphoryl binding to the enzyme and can explain why the binding of the phosphoryl group is essential for the catalytic function.

-	~~{{STRUCTURE_1l2u\| PDB=1l2u \| SCENE= }}~~	+	Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase.,Harris P, Poulsen JC, Jensen KF, Larsen S J Mol Biol. 2002 May 10;318(4):1019-29. PMID:12054799<ref>PMID:12054799</ref>

-	~~===Orotidine 5'-monophosphate decarboxylase from E. coli===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12054799}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1l2u]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012054799<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]

OCA: Protected "1l2u" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 20:19:16 GMT

Protected "1l2u" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:19, 5 December 2012

OCA at 20:19, 5 December 2012

OCA — Wed, 05 Dec 2012 20:19:13 GMT

←Older revision		Revision as of 20:19, 5 December 2012
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-	{{Seed}}
	[[Image:1l2u.png\|left\|200px]]		[[Image:1l2u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1l2u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1l2u\| PDB=1l2u \| SCENE= }}		{{STRUCTURE_1l2u\| PDB=1l2u \| SCENE= }}

	===Orotidine 5'-monophosphate decarboxylase from E. coli===		===Orotidine 5'-monophosphate decarboxylase from E. coli===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12054799}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12054799 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12054799}}		{{ABSTRACT_PUBMED_12054799}}

	==About this Structure==		==About this Structure==
-	~~1L2U~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA].	+	[[1l2u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2U OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12054799~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012054799</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
Line 32:		Line 20:
	[[Category: Beta-alpha-barrel]]		[[Category: Beta-alpha-barrel]]
	[[Category: Homodimer]]		[[Category: Homodimer]]
		+	[[Category: Lyase]]
	[[Category: Twinned crystal]]		[[Category: Twinned crystal]]
-	[[Category: X-ray diffraction]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:44:07 2009''